The SARS-CoV-2 receptor ACE2 is expressed in mouse pericytes but not endothelial cells : Implications for COVID-19 vascular research

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Muhl , L , He , L , Sun , Y , Mae , M A , Pietila , R , Liu , J , Genove , G , Zhang , L , Xie , Y , Leptidis , S , Mocci , G , Stritt , S , Osman , A , Anisimov , A , Hemanthakumar , K A , Räsänen , M , Hansson , E M , Bjorkegren , J , Vanlandewijck , M , Blomgren , K , Makinen , T , Peng , X-R , Hu , Y , Ernfors , P , Arnold , T D , Alitalo , K , Lendahl , U & Betsholtz , C 2022 , ' The SARS-CoV-2 receptor ACE2 is expressed in mouse pericytes but not endothelial cells : Implications for COVID-19 vascular research ' , Stem cell reports , vol. 17 , no. 5 , pp. 1089-1104 . https://doi.org/10.1016/j.stemcr.2022.03.016

Title: The SARS-CoV-2 receptor ACE2 is expressed in mouse pericytes but not endothelial cells : Implications for COVID-19 vascular research
Author: Muhl, Lars; He, Liqun; Sun, Ying; Mae, Maarja Andaloussi; Pietila, Riikka; Liu, Jianping; Genove, Guillem; Zhang, Lei; Xie, Yuan; Leptidis, Stefanos; Mocci, Giuseppe; Stritt, Simon; Osman, Ahmed; Anisimov, Andrey; Hemanthakumar, Karthik Amudhala; Räsänen, Markus; Hansson, Emil M.; Bjorkegren, Johan; Vanlandewijck, Michael; Blomgren, Klas; Makinen, Taija; Peng, Xiao-Rong; Hu, Yizhou; Ernfors, Patrik; Arnold, Thomas D.; Alitalo, Kari; Lendahl, Urban; Betsholtz, Christer
Contributor organization: CAN-PRO - Translational Cancer Medicine Program
University of Helsinki
Medicum
Kivelä Lab
Research Programs Unit
HUSLAB
Kari Alitalo / Principal Investigator
Date: 2022-05-10
Language: eng
Number of pages: 16
Belongs to series: Stem cell reports
ISSN: 2213-6711
DOI: https://doi.org/10.1016/j.stemcr.2022.03.016
URI: http://hdl.handle.net/10138/345993
Abstract: Humanized mouse models and mouse-adapted SARS-CoV-2 virus are increasingly used to study COVID-19 pathogenesis, so it is impor-tant to learn where the SARS-CoV-2 receptor ACE2 is expressed. Here we mapped ACE2 expression during mouse postnatal development and in adulthood. Pericytes in the CNS, heart, and pancreas express ACE2 strongly, as do perineurial and adrenal fibroblasts, whereas endothelial cells do not at any location analyzed. In a number of other organs, pericytes do not express ACE2, including in the lung where ACE2 instead is expressed in bronchial epithelium and alveolar type II cells. The onset of ACE2 expression is organ specific: in bronchial epithelium already at birth, in brain pericytes before, andin heart pericytes after postnatal day 10.5. Establishing the vascular localization of ACE2 expression is central to correctly interpret data from modeling COVID-19 in the mouse and may shed light on the cause of vascular COVID-19 complications.
Subject: INFECTION
3111 Biomedicine
1182 Biochemistry, cell and molecular biology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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