The SARS-CoV-2 receptor ACE2 is expressed in mouse pericytes but not endothelial cells : Implications for COVID-19 vascular research

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dc.contributor.author Muhl, Lars
dc.contributor.author He, Liqun
dc.contributor.author Sun, Ying
dc.contributor.author Mae, Maarja Andaloussi
dc.contributor.author Pietila, Riikka
dc.contributor.author Liu, Jianping
dc.contributor.author Genove, Guillem
dc.contributor.author Zhang, Lei
dc.contributor.author Xie, Yuan
dc.contributor.author Leptidis, Stefanos
dc.contributor.author Mocci, Giuseppe
dc.contributor.author Stritt, Simon
dc.contributor.author Osman, Ahmed
dc.contributor.author Anisimov, Andrey
dc.contributor.author Hemanthakumar, Karthik Amudhala
dc.contributor.author Räsänen, Markus
dc.contributor.author Hansson, Emil M.
dc.contributor.author Bjorkegren, Johan
dc.contributor.author Vanlandewijck, Michael
dc.contributor.author Blomgren, Klas
dc.contributor.author Makinen, Taija
dc.contributor.author Peng, Xiao-Rong
dc.contributor.author Hu, Yizhou
dc.contributor.author Ernfors, Patrik
dc.contributor.author Arnold, Thomas D.
dc.contributor.author Alitalo, Kari
dc.contributor.author Lendahl, Urban
dc.contributor.author Betsholtz, Christer
dc.date.accessioned 2022-07-07T22:30:34Z
dc.date.available 2022-07-07T22:30:34Z
dc.date.issued 2022-05-10
dc.identifier.citation Muhl , L , He , L , Sun , Y , Mae , M A , Pietila , R , Liu , J , Genove , G , Zhang , L , Xie , Y , Leptidis , S , Mocci , G , Stritt , S , Osman , A , Anisimov , A , Hemanthakumar , K A , Räsänen , M , Hansson , E M , Bjorkegren , J , Vanlandewijck , M , Blomgren , K , Makinen , T , Peng , X-R , Hu , Y , Ernfors , P , Arnold , T D , Alitalo , K , Lendahl , U & Betsholtz , C 2022 , ' The SARS-CoV-2 receptor ACE2 is expressed in mouse pericytes but not endothelial cells : Implications for COVID-19 vascular research ' , Stem cell reports , vol. 17 , no. 5 , pp. 1089-1104 . https://doi.org/10.1016/j.stemcr.2022.03.016
dc.identifier.other PURE: 216112946
dc.identifier.other PURE UUID: cf1ffc13-366d-4665-a25c-656638791bba
dc.identifier.other WOS: 000803988700012
dc.identifier.other ORCID: /0000-0001-6151-1005/work/115595849
dc.identifier.uri http://hdl.handle.net/10138/345993
dc.description.abstract Humanized mouse models and mouse-adapted SARS-CoV-2 virus are increasingly used to study COVID-19 pathogenesis, so it is impor-tant to learn where the SARS-CoV-2 receptor ACE2 is expressed. Here we mapped ACE2 expression during mouse postnatal development and in adulthood. Pericytes in the CNS, heart, and pancreas express ACE2 strongly, as do perineurial and adrenal fibroblasts, whereas endothelial cells do not at any location analyzed. In a number of other organs, pericytes do not express ACE2, including in the lung where ACE2 instead is expressed in bronchial epithelium and alveolar type II cells. The onset of ACE2 expression is organ specific: in bronchial epithelium already at birth, in brain pericytes before, andin heart pericytes after postnatal day 10.5. Establishing the vascular localization of ACE2 expression is central to correctly interpret data from modeling COVID-19 in the mouse and may shed light on the cause of vascular COVID-19 complications. en
dc.format.extent 16
dc.language.iso eng
dc.relation.ispartof Stem cell reports
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject INFECTION
dc.subject 3111 Biomedicine
dc.subject 1182 Biochemistry, cell and molecular biology
dc.title The SARS-CoV-2 receptor ACE2 is expressed in mouse pericytes but not endothelial cells : Implications for COVID-19 vascular research en
dc.type Article
dc.contributor.organization CAN-PRO - Translational Cancer Medicine Program
dc.contributor.organization University of Helsinki
dc.contributor.organization Medicum
dc.contributor.organization Kivelä Lab
dc.contributor.organization Research Programs Unit
dc.contributor.organization HUSLAB
dc.contributor.organization Kari Alitalo / Principal Investigator
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1016/j.stemcr.2022.03.016
dc.relation.issn 2213-6711
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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