Tensin2 Is a Novel Diagnostic Marker in GIST, Associated with Gastric Location and Non-Metastatic Tumors

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Salmikangas, S.; Böhling, T.; Merikoski, N.; Jagdeo, J.; Sampo, M.; Vesterinen, T.; Sihto, H. Tensin2 Is a Novel Diagnostic Marker in GIST, Associated with Gastric Location and Non-Metastatic Tumors. Cancers 2022, 14, 3212.

Title: Tensin2 Is a Novel Diagnostic Marker in GIST, Associated with Gastric Location and Non-Metastatic Tumors
Author: Salmikangas, Sami; Böhling, Tom; Merikoski, Nanna; Jagdeo, Joanna; Sampo, Mika; Vesterinen, Tiina; Sihto, Harri
Publisher: Multidisciplinary Digital Publishing Institute
Date: 2022-06-30
URI: http://hdl.handle.net/10138/346022
Abstract: GIST is a rare soft tissue sarcoma, for which KIT and DOG1 are used as highly sensitive diagnostic markers. Other diagnostic markers include CD34, protein kinase C &theta;, deficiency of succinate dehydrogenase complex subunit B, carbonic anhydrase II, and type I insulin-like growth factor receptor. We investigated the role of TNS2 as a diagnostic biomarker by using immunohistochemistry in 176 GISTs and 521 other sarcomas. All GISTs expressed TNS2, with intermediate or high expression in 71.4% of samples. The majority (89.8%) of other sarcomas were negative for TNS2, and intermediate to strong staining was only seen in 2.9% of samples. Strong TNS2 staining was associated with gastric location (gastric 52.8% vs. non-gastric 7.2%; <i>p</i> &lt; 0.001), absence of metastases (non-metastatic tumors 44.3% vs. metastatic tumors 5.9%; <i>p</i> = 0.004), female sex (female 45.9% vs. male 33.8%; <i>p</i> = 0.029), and tumors of lower risk categories (very low or low 46.9% vs. intermediate 51.7% vs. high 29.0%; <i>p</i> = 0.020). TNS2 expression did not correlate with overall survival or metastasis-free survival. No associations between TNS2 expression and KIT/PDGFRA mutation status, tumor size, mitotic count, or age of the patient were detected. The results provide conclusive evidence for the value of TNS2 as a sensitive and specific diagnostic biomarker for GIST.


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