Age at Separation of Twin Pairs in the FinnTwin12 Study

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Wang , Z , Whipp , A , Heinonen-Guzejev , M & Kaprio , J 2022 , ' Age at Separation of Twin Pairs in the FinnTwin12 Study ' , Twin Research and Human Genetics , vol. 25 , no. 2 , pp. 67-73 .

Title: Age at Separation of Twin Pairs in the FinnTwin12 Study
Author: Wang, Zhiyang; Whipp, Alyce; Heinonen-Guzejev, Marja; Kaprio, Jaakko
Contributor organization: Institute for Molecular Medicine Finland
Genetic Epidemiology
Department of Public Health
University of Helsinki
Date: 2022-05-22
Language: eng
Number of pages: 7
Belongs to series: Twin Research and Human Genetics
ISSN: 1832-4274
Abstract: Living in the same household exposes family members to shared environments and may be reflected in estimates of shared environment in twin analyses. The age at the separation of cotwins in a twin pair marks the end of such shared exposure, and the age of separation is commonly self-reported in studies. The objective of the study was to summarize the age at separation from residential records and use it to validate with self-reported separation status and age at the third and fourth wave of data collection in the FinnTwin12 cohort. Age at separation was generated from the address information, linking it to the Finnish Population information system since birth. Descriptive statistics by sex and zygosity are presented. The mean age at separation from residential records was 20.36 years old. Women separated earlier than men and dizygotic pairs earlier than monozygotic pairs. We also calculated the sensitivity and specificity with the self-reported separation status at waves 3 and 4, and interrater reliability with the self-reported separation age at wave 4. Age at separation from residential records had a relatively poor agreement with the self-report. This work enables us to use a more precise and objective measure for the shared environment in future twin studies.
Subject: Twin
residential record
age at separation
1184 Genetics, developmental biology, physiology
3123 Gynaecology and paediatrics
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion

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