Brain volumes and abnormalities in adults born preterm at very low birth weight

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Kuula , J , Martola , J , Hakkarainen , A , Räikkönen , K , Savolainen , S , Salli , E , Hovi , P , Björkqvist , J , Kajantie , E & Lundbom , N 2022 , ' Brain volumes and abnormalities in adults born preterm at very low birth weight ' , The Journal of Pediatrics , vol. 246 , pp. 48-+ . https://doi.org/10.1016/j.jpeds.2022.03.009

Title: Brain volumes and abnormalities in adults born preterm at very low birth weight
Author: Kuula, Juho; Martola, Juha; Hakkarainen, Antti; Räikkönen, Katri; Savolainen, Sauli; Salli, Eero; Hovi, Petteri; Björkqvist, Johan; Kajantie, Eero; Lundbom, Nina
Contributor organization: HUS Medical Imaging Center
HUS Diagnostic Center
Department of Diagnostics and Therapeutics
Department of Psychology and Logopedics
Helsinki In Vivo Animal Imaging Platform (HAIP)
Department of Physics
Sauli Savolainen / Principal Investigator
HUS Children and Adolescents
Lastentautien yksikkö
Children's Hospital
Clinicum
Date: 2022-07
Language: eng
Number of pages: 15
Belongs to series: The Journal of Pediatrics
ISSN: 0022-3476
DOI: https://doi.org/10.1016/j.jpeds.2022.03.009
URI: http://hdl.handle.net/10138/346062
Abstract: Objectives To assess radiographic brain abnormalities and investigate volumetric differences in adults born preterm at very low birth weight ( Study design We recruited 79 adult same-sex sibling pairs with one born preterm at very low birth weight and the sibling at term. We acquired 3-T brain magnetic resonance imaging from 78 preterm participants and 72 siblings. A neuroradiologist, masked to participants' prematurity status, reviewed the images for parenchymal and structural abnormalities, and FreeSurfer software 6.0 was used to conduct volumetric analyses. Data were analyzed by linear mixed models. Results We found more structural abnormalities in very low birth weight participants than in siblings (37% vs 13%). The most common finding was periventricular leukomalacia, present in 15% of very low birth weight participants and in 3% of siblings. The very low birth weight group had smaller absolute brain volumes (-0.4 SD) and, after adjusting for estimated intracranial volume, less gray matter (-0.2 SD), larger ventricles (1.5 SD), smaller thalami (-0.6 SD), caudate nuclei (-0.4 SD), right hippocampus (-0.4 SD), and left pallidum (-0.3 SD). We saw no volume differences in total white matter (-0.04 SD; 95% CI, -0.13 to 0.09). Conclusions Preterm very low birth weight adults had a higher prevalence of brain abnormalities than their termborn siblings. They also had smaller absolute brain volumes, less gray but not white matter, and smaller volumes in several gray matter structures.
Subject: ADOLESCENTS
CHILDREN
HEALTH
INJURY
METAANALYSIS
OUTCOMES
RISK-FACTORS
SEGMENTATION
YOUNG-ADULTS
3123 Gynaecology and paediatrics
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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