APOE Genotypes, Lipid Profiles, and Associated Clinical Markers in a Finnish Population with Cardiovascular Disease Risk Factors

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http://hdl.handle.net/10138/346067

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Leskinen , H , Tringham , M , Karjalainen , H , Iso-Touru , T , Hietaranta-Luoma , H-L , Marnila , P , Pihlava , J-M , Hurme , T , Puolijoki , H , Åkerman , K , Mäkinen , S , Sandell , M , Vähäkangas , K , Tahvonen , R , Rokka , S & Hopia , A 2022 , ' APOE Genotypes, Lipid Profiles, and Associated Clinical Markers in a Finnish Population with Cardiovascular Disease Risk Factors ' , Lifestyle genomics , vol. 15 , pp. 45-54 . https://doi.org/10.1159/000520864

Title: APOE Genotypes, Lipid Profiles, and Associated Clinical Markers in a Finnish Population with Cardiovascular Disease Risk Factors
Author: Leskinen, Heidi; Tringham, Maaria; Karjalainen, H.; Iso-Touru, T.; Hietaranta-Luoma, Hanna-Leena; Marnila, P.; Pihlava, J.-M.; Hurme, T.; Puolijoki, H.; Åkerman, K.; Mäkinen, Sari; Sandell, Mari; Vähäkangas, K.; Tahvonen, R.; Rokka, Susanna; Hopia, Anu
Contributor organization: Department of Food and Nutrition
Senses and Food
Date: 2022
Language: eng
Number of pages: 10
Belongs to series: Lifestyle genomics
ISSN: 2504-3161
DOI: https://doi.org/10.1159/000520864
URI: http://hdl.handle.net/10138/346067
Abstract: Introduction: The APOE ε4 allele predisposes to high cholesterol and increases the risk for lifestyle-related diseases such as Alzheimer’s disease and cardiovascular diseases (CVDs). The aim of this study was to analyse interrelationships of APOE genotypes with lipid metabolism and lifestyle factors in middle-aged Finns among whom the CVD risk factors are common. Methods: Participants (n = 211) were analysed for APOE ε genotypes, physiological parameters, and health- and diet-related plasma markers. Lifestyle choices were determined by a questionnaire. Results: APOE genotypes ε3/ε4 and ε4/ε4 (ε4 group) represented 34.1% of the participants. Genotype ε3/ε3 (ε3 group) frequency was 54.5%. Carriers of ε2 (ε2 group; ε2/ε2, ε2/ε3 and ε2/ε4) represented 11.4%; 1.9% were of the genotype ε2/ε4. LDL and total cholesterol levels were lower (p < 0.05) in the ε2 carriers than in the ε3 or ε4 groups, while the ε3 and ε4 groups did not differ. Proportions of plasma saturated fatty acids (SFAs) were higher (p < 0.01), and omega-6 fatty acids lower (p = 0.01) in the ε2 carriers compared with the ε4 group. The ε2 carriers had a higher (p < 0.05) percentage of 22:4n-6 and 22:5n-6 and a lower (p < 0.05) percentage of 24:5n-3 and 24:6n-3 than individuals without the ε2 allele. Conclusions: The plasma fatty-acid profiles in the ε2 group were characterized by higher SFA and lower omega-6 fatty-acid proportions. Their lower cholesterol values indicated a lower risk for CVD compared with the ε4 group. A novel finding was that the ε2 carriers had different proportions of 22:4n-6, 22:5n-6, 24:5n-3, and 24:6n-3 than individuals without the ε2 allele. The significance of the differences in fatty-acid composition remains to be studied.
Subject: ADVICE
ALZHEIMERS-DISEASE
APOE
APOLIPOPROTEIN-E
CHOLESTEROL
DEMENTIA
FATTY-ACID-COMPOSITION
Fatty acid
Genetic variation
INTERVENTION
Lifestyle
Lipid
METABOLISM
PLASMA
RESPONSIVENESS
3143 Nutrition
Peer reviewed: Yes
Rights: cc_by_nc
Usage restriction: openAccess
Self-archived version: publishedVersion


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