Longitudinal evolution of catheter-related bloodstream infections, kidney function and liver status in a nationwide adult intestinal failure cohort

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http://hdl.handle.net/10138/346123

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Pohju , A K , Hakkarainen , A , Pakarinen , M P & Sipponen , T M 2022 , ' Longitudinal evolution of catheter-related bloodstream infections, kidney function and liver status in a nationwide adult intestinal failure cohort ' , Scandinavian Journal of Gastroenterology , vol. 57 , no. 7 , pp. 763-767 . https://doi.org/10.1080/00365521.2022.2039281

Title: Longitudinal evolution of catheter-related bloodstream infections, kidney function and liver status in a nationwide adult intestinal failure cohort
Author: Pohju, Anne K.; Hakkarainen, Antti; Pakarinen, Mikko P.; Sipponen, Taina M.
Contributor organization: Clinicum
HUS Internal Medicine and Rehabilitation
HUS Medical Imaging Center
Children's Hospital
Lastenkirurgian yksikkö
HUS Children and Adolescents
Gastroenterologian yksikkö
HUS Abdominal Center
Date: 2022-07-03
Language: eng
Number of pages: 5
Belongs to series: Scandinavian Journal of Gastroenterology
ISSN: 0036-5521
DOI: https://doi.org/10.1080/00365521.2022.2039281
URI: http://hdl.handle.net/10138/346123
Abstract: Objectives The development of intestinal failure-related complications in Finnish adults is unknown. This study aimed to investigate the incidence of catheter-related bloodstream infections (CRBSI), and the longitudinal changes in biochemical liver and kidney tests in a nationwide cohort. Materials and methods The search for Finnish adults with intestinal failure (IF) utilized a survey to Finnish health-care providers (n = 111) with the potential to provide long-term parenteral support (PS) for adult IF. Our nationwide, cross-sectional cohort included all IF patients aged >= 18 years who had received PS for >= 120 d in 2017. Data regarding CRBSI and biochemical liver and kidney tests were collected from patient records at the start of PS up to the latest available measurement in 2017. Results In the nationwide cohort of 52 patients, the CRBSI incidence was 1.35/1000 catheter days. Seventy-three percent of CRBSI in a long-term catheter led to catheter replacement. During a median PS duration of 27.5 (interquartile range [IQR] 11.3-57.3) months, a statistically significant median change occurred in estimated glomerular filtration rate (eGFR; -8.5 ml/min/1.73 m(2), IQR -30-7, p = .005) and alkaline phosphatase (ALP; 26 U/l, IQR -11-95, p = .019). In a multiple regression model for eGFR at data collection, baseline eGFR and age were strong explanatory variables. Conclusions Incidence of CRBSI, but not treatment strategies, in this nationwide adult IF population correspond well to those reported from specialized centers. Decreased kidney function and abnormal liver test results are frequent findings, and even more so over time, emphasizing the importance of regular monitoring.
Subject: Short bowel syndrome
renal failure
IFALD
home parenteral nutrition
CRBSI
HOME PARENTERAL-NUTRITION
RENAL-FUNCTION
RISK-FACTORS
PREVALENCE
CLASSIFICATION
COMPLICATIONS
GUIDELINES
MANAGEMENT
DISEASE
HPN
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: publishedVersion


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