Optimal Doses of Specific Antipsychotics for Relapse Prevention in a Nationwide Cohort of Patients with Schizophrenia

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Taipale , H , Tanskanen , A , Luykx , J J , Solmi , M , Leucht , S , Correll , C U & Tiihonen , J 2022 , ' Optimal Doses of Specific Antipsychotics for Relapse Prevention in a Nationwide Cohort of Patients with Schizophrenia ' , Schizophrenia bulletin , vol. 48 , no. 4 , pp. 774-784 . https://doi.org/10.1093/schbul/sbac039

Title: Optimal Doses of Specific Antipsychotics for Relapse Prevention in a Nationwide Cohort of Patients with Schizophrenia
Author: Taipale, Heidi; Tanskanen, Antti; Luykx, Jurjen J.; Solmi, Marco; Leucht, Stefan; Correll, Christoph U.; Tiihonen, Jari
Contributor organization: Neuroscience Center
Clinicum
Date: 2022-06-21
Language: eng
Number of pages: 11
Belongs to series: Schizophrenia bulletin
ISSN: 0586-7614
DOI: https://doi.org/10.1093/schbul/sbac039
URI: http://hdl.handle.net/10138/346127
Abstract: Background and Hypothesis Optimal doses of most antipsychotics in the maintenance treatment of schizophrenia are unknown. We aimed to study the risk of severe relapse indicated by rehospitalization for different dose categories of 15 most frequently used antipsychotics in monotherapy in Finland. Study Methods We studied the risk of rehospitalization (Adjusted Hazard Ratio, aHR) associated with six antipsychotic monotherapy dose categories (as time-varying dose, measured in defined daily dose, DDDs/day) in a nationwide cohort of persons diagnosed with schizophrenia (n = 61 889), using within-individual analyses to eliminate selection bias. Study Results Among the 15 most widely used antipsychotics, 13 had a U- or J-shaped dose-response curve, showing the lowest risks of relapse for doses of 0.6-0.9 DDD/day, and especially at 1.4-
Subject: psychosis
prevention
hospitalization
2ND-GENERATION ANTIPSYCHOTICS
METAANALYSIS
DISORDERS
3112 Neurosciences
3124 Neurology and psychiatry
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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