Taipale , H , Tanskanen , A , Luykx , J J , Solmi , M , Leucht , S , Correll , C U & Tiihonen , J 2022 , ' Optimal Doses of Specific Antipsychotics for Relapse Prevention in a Nationwide Cohort of Patients with Schizophrenia ' , Schizophrenia bulletin , vol. 48 , no. 4 , pp. 774-784 . https://doi.org/10.1093/schbul/sbac039
Title: | Optimal Doses of Specific Antipsychotics for Relapse Prevention in a Nationwide Cohort of Patients with Schizophrenia |
Author: | Taipale, Heidi; Tanskanen, Antti; Luykx, Jurjen J.; Solmi, Marco; Leucht, Stefan; Correll, Christoph U.; Tiihonen, Jari |
Contributor organization: | Neuroscience Center Clinicum |
Date: | 2022-06-21 |
Language: | eng |
Number of pages: | 11 |
Belongs to series: | Schizophrenia bulletin |
ISSN: | 0586-7614 |
DOI: | https://doi.org/10.1093/schbul/sbac039 |
URI: | http://hdl.handle.net/10138/346127 |
Abstract: | Background and Hypothesis Optimal doses of most antipsychotics in the maintenance treatment of schizophrenia are unknown. We aimed to study the risk of severe relapse indicated by rehospitalization for different dose categories of 15 most frequently used antipsychotics in monotherapy in Finland. Study Methods We studied the risk of rehospitalization (Adjusted Hazard Ratio, aHR) associated with six antipsychotic monotherapy dose categories (as time-varying dose, measured in defined daily dose, DDDs/day) in a nationwide cohort of persons diagnosed with schizophrenia (n = 61 889), using within-individual analyses to eliminate selection bias. Study Results Among the 15 most widely used antipsychotics, 13 had a U- or J-shaped dose-response curve, showing the lowest risks of relapse for doses of 0.6-0.9 DDD/day, and especially at 1.4- |
Subject: |
psychosis
prevention hospitalization 2ND-GENERATION ANTIPSYCHOTICS METAANALYSIS DISORDERS 3112 Neurosciences 3124 Neurology and psychiatry |
Peer reviewed: | Yes |
Rights: | cc_by |
Usage restriction: | openAccess |
Self-archived version: | publishedVersion |
Total number of downloads: Loading...
Files | Size | Format | View |
---|---|---|---|
sbac039.pdf | 1.165Mb |
View/ |