Peripheral differentiation patterns of human T cells

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Heikkilä , N , Hetemäki , I , Sormunen , S , Isoniemi , H , Kekäläinen , E , Saramäki , J & Arstila , T P 2022 , ' Peripheral differentiation patterns of human T cells ' , European Journal of Immunology , vol. 52 , no. 6 , pp. 882-894 . https://doi.org/10.1002/eji.202149465

Title: Peripheral differentiation patterns of human T cells
Author: Heikkilä, Nelli; Hetemäki, Iivo; Sormunen, Silja; Isoniemi, Helena; Kekäläinen, Eliisa; Saramäki, Jari; Arstila, T. Petteri
Contributor organization: Department of Bacteriology and Immunology
TRIMM - Translational Immunology Research Program
University of Helsinki
Faculty of Medicine
HUS Abdominal Center
IV kirurgian klinikka
Clinicum
Medicum
HUSLAB
Helsinki University Hospital Area
Research Programs Unit
Petteri Arstila / Principal Investigator
Date: 2022-06
Language: eng
Number of pages: 13
Belongs to series: European Journal of Immunology
ISSN: 0014-2980
DOI: https://doi.org/10.1002/eji.202149465
URI: http://hdl.handle.net/10138/346130
Abstract: Long-term T-cell memory is dependent on the maintenance of memory T cells in the lymphoid tissues, and at the surface interfaces that provide entry routes for pathogens. However, much of the current information on human T-cell memory is based on analyzing circulating T cells. Here, we have studied the distribution and age-related changes of memory T-cell subsets in samples from blood, mesenteric LNs, spleen, and ileum, obtained from donors ranging in age from 5 days to 67 years of age. Our data show that the main reservoir of polyclonal naive cells is found in the LNs, and the resting memory subsets capable of self-renewal are also prominent there. In contrast, nondividing but functionally active memory subsets dominate the spleen, and especially the ileum. In general, the replacement of naive cells with memory subsets continues throughout our period of observation, with no apparent plateau. In conclusion, the analysis of lymphoid and nonlymphoid tissues reveals a dynamic pattern of changes distinct to each tissue, and with substantial differences between CD4(+) and CD8(+) compartments.
Subject: T-cell homeostasis
T-cell memory
Recent thymic emigrant T cell
Lymphatic tissue
MEMORY STEM-CELLS
EMERGING CONCEPTS
HUMAN NAIVE
COMPARTMENTALIZATION
HOMEOSTASIS
REPERTOIRE
INVOLUTION
DIVERSITY
INFECTION
IMMUNITY
3111 Biomedicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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