Near-infrared analysis of nanofibrillated cellulose aerogel manufacturing

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Merivaara , A , Kekkonen , J , Monola , J , Koivunotko , E , Savolainen , M , Silvast , T , Svedstrom , K , Diaz , A , Holler , M , Korhonen , O , Yliperttula , M & Valkonen , S 2022 , ' Near-infrared analysis of nanofibrillated cellulose aerogel manufacturing ' , International Journal of Pharmaceutics , vol. 617 , 121581 .

Title: Near-infrared analysis of nanofibrillated cellulose aerogel manufacturing
Author: Merivaara, Arto; Kekkonen, Jere; Monola, Julia; Koivunotko, Elle; Savolainen, Marko; Silvast, Tuomo; Svedstrom, Kirsi; Diaz, Ana; Holler, Mirko; Korhonen, Ossi; Yliperttula, Marjo; Valkonen, Sami
Contributor organization: Biopharmaceutics Group
Division of Pharmaceutical Biosciences
Divisions of Faculty of Pharmacy
Department of Physics
Drug Research Program
Date: 2022-04-05
Language: eng
Number of pages: 12
Belongs to series: International Journal of Pharmaceutics
ISSN: 0378-5173
Abstract: Biomaterial aerogel fabrication by freeze-drying must be further improved to reduce the costs of lengthy freeze-drying cycles and to avoid the formation of spongy cryogels and collapse of the aerogel structures. Residual water content is a critical quality attribute of the freeze-dried product, which can be monitored in-line with near-infrared (NIR) spectroscopy. Predictive models of NIR have not been previously applied for biomaterials and the models were mostly focused on the prediction of only one formulation at a time. We recorded NIR spectra of different nanofibrillated cellulose (NFC) hydrogel formulations during the secondary drying and set up a partial least square regression model to predict their residual water contents. The model can be generalized to measure residual water of formulations with different NFC concentrations and the excipients, and the NFC fiber concentrations and excipients can be separated with the principal component analysis. Our results provide valuable information about the freeze-drying of biomaterials and aerogel fabrication, and how NIR spectroscopy can be utilized in the optimization of residual water content.
Subject: 317 Pharmacy
114 Physical sciences
1182 Biochemistry, cell and molecular biology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion

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