Expression of markers of stem cell characteristics, epithelial-mesenchymal transition, basal-like phenotype, proliferation, and androgen receptor in metaplastic breast cancer and their prognostic impact

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Voutilainen , S , Heikkila , P , Sampo , M , Nevanlinna , H , Blomqvist , C & Mattson , J 2021 , ' Expression of markers of stem cell characteristics, epithelial-mesenchymal transition, basal-like phenotype, proliferation, and androgen receptor in metaplastic breast cancer and their prognostic impact ' , Acta Oncologica , vol. 60 , no. 9 , pp. 1233-1239 . https://doi.org/10.1080/0284186X.2021.1950927

Title: Expression of markers of stem cell characteristics, epithelial-mesenchymal transition, basal-like phenotype, proliferation, and androgen receptor in metaplastic breast cancer and their prognostic impact
Author: Voutilainen, Sari; Heikkila, Paivi; Sampo, Mika; Nevanlinna, Heli; Blomqvist, Carl; Mattson, Johanna
Contributor organization: HUS Comprehensive Cancer Center
Department of Oncology
Department of Pathology
HUSLAB
Department of Obstetrics and Gynecology
HUS Gynecology and Obstetrics
Medicum
Clinicum
Date: 2021-09-02
Language: eng
Number of pages: 7
Belongs to series: Acta Oncologica
ISSN: 0284-186X
DOI: https://doi.org/10.1080/0284186X.2021.1950927
URI: http://hdl.handle.net/10138/346286
Abstract: Background Metaplastic breast cancer (MpBC) is a heterogeneous subtype of invasive mammary carcinoma associated with epithelial-mesenchymal transition (EMT) and cancer stem cell characteristics. Data regarding prognostic markers and potentially actionable targets for therapy are still limited. The present study aimed to characterize the immunohistochemical landscape of this rare malignancy and to identify potential prognostic factors and targets for therapy. Material and methods A total of 75 patients diagnosed with MpBC over a 15-year period were included in the study. We performed immunohistochemical analyses for Ki-67 (MIB-1), epidermal growth factor receptor (EGFR), cytokeratin 5/6, vimentin, CD44, and androgen receptor (AR) and correlated their expression with clinicopathologic features and clinical outcomes. The p-values for survival analyses were corrected for multiple testing (threshold 0.01). Results Most tumors expressed CK5/6 (73%), EGFR (59%), CD44 (81%), and vimentin (87%). Eighty-nine percent had a high Ki-67 index. Eighty-four percent were classified as basal-like (CK 5/6 or EGFR positive). AR was expressed in 21% of the tumors. The basal-like phenotype was significantly (p = 0.009) associated with inferior disease-free (DFS) and breast-cancer-specific overall survival (BCOS) with borderline significance (p = 0.01). In addition, a low Ki-67 index was associated with improved DFS (p = 0.033) and BCOS (p = 0.03). Conclusion Most MpBCs express basal markers (CK5/6, EGFR), epithelial-mesenchymal transition marker vimentin, and the stem cell marker CD44. Expression of basal-like markers was significantly related to inferior DFS. All the 11 patients with a lack of expression of basal markers survived without relapse.
Subject: Metaplastic breast cancer
vimentin
CD44
AR
basal-like breast cancer
PHASE-II
CARCINOMA
3122 Cancers
Peer reviewed: Yes
Rights: cc_by_nc
Usage restriction: openAccess
Self-archived version: acceptedVersion


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