Prognostic Value of Stromal Type IV Collagen Expression in Small Invasive Breast Cancers

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Jansson , M , Lindberg , J , Rask , G , Svensson , J , Billing , O , Nazemroaya , A , Berglund , A , Wärnberg , F & Sund , M 2022 , ' Prognostic Value of Stromal Type IV Collagen Expression in Small Invasive Breast Cancers ' , Frontiers in Molecular Biosciences , vol. 9 , 904526 . https://doi.org/10.3389/fmolb.2022.904526

Title: Prognostic Value of Stromal Type IV Collagen Expression in Small Invasive Breast Cancers
Author: Jansson, Malin; Lindberg, Jessica; Rask, Gunilla; Svensson, Johan; Billing, Ola; Nazemroaya, Anoosheh; Berglund, Anette; Wärnberg, Fredrik; Sund, Malin
Contributor organization: Department of Surgery
University of Helsinki
Date: 2022-05-25
Language: eng
Number of pages: 9
Belongs to series: Frontiers in Molecular Biosciences
ISSN: 2296-889X
DOI: https://doi.org/10.3389/fmolb.2022.904526
URI: http://hdl.handle.net/10138/346307
Abstract: Breast cancer is the most common cause of cancer death among women worldwide. Localized breast cancer can be cured by surgery and adjuvant therapy, but mortality remains high for tumors that metastasize early. Type IV collagen is a basement membrane protein, and breach of this extracellular matrix structure is the first step of cancer invasion. Type IV collagen is found in the stroma of many cancers, but its role in tumor biology is unclear. Here, expression of type IV collagen in the stroma of small breast cancers was analyzed, correlated to clinically used prognostic biomarkers and patient survival. The findings were further validated in an independent gene expression data cohort. Tissue samples from 1,379 women with in situ and small invasive breast cancers (
Subject: type IV collagen
breast cancer
extracellular matrix
tumor progression
tumor microenvironment
COLORECTAL-CANCER
TUMOR INVASION
MATRIX
CHAINS
SUBTYPES
1182 Biochemistry, cell and molecular biology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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