Pleuropulmonary pathologies in the early phase of acute pancreatitis correlate with disease severity

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http://hdl.handle.net/10138/346334

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Luiken , I , Eisenmann , S , Garbe , J , Sternby , H , Verdonk , R C , Dimova , A , Ignatavicius , P , Ilzarbe , L , Koiva , P , Penttilä , A K , Regner , S , Dober , J , Wohlgemuth , W A , Brill , R , Michl , P , Rosendahl , J & Damm , M 2022 , ' Pleuropulmonary pathologies in the early phase of acute pancreatitis correlate with disease severity ' , PLoS One , vol. 17 , no. 2 , 0263739 . https://doi.org/10.1371/journal.pone.026373

Title: Pleuropulmonary pathologies in the early phase of acute pancreatitis correlate with disease severity
Author: Luiken, Ina; Eisenmann, Stephan; Garbe, Jakob; Sternby, Hanna; Verdonk, Robert C.; Dimova, Alexandra; Ignatavicius, Povilas; Ilzarbe, Lucas; Koiva, Peeter; Penttilä, Anne K.; Regner, Sara; Dober, Johannes; Wohlgemuth, Walter A.; Brill, Richard; Michl, Patrick; Rosendahl, Jonas; Damm, Marko
Contributor organization: HUS Abdominal Center
Department of Surgery
Clinicum
Date: 2022-02-07
Language: eng
Number of pages: 13
Belongs to series: PLoS One
ISSN: 1932-6203
DOI: https://doi.org/10.1371/journal.pone.026373
URI: http://hdl.handle.net/10138/346334
Abstract: Background Respiratory failure worsens the outcome of acute pancreatitis (AP) and underlying factors might be early detectable. Aims To evaluate the prevalence and prognostic relevance of early pleuropulmonary pathologies and pre-existing chronic lung diseases (CLD) in AP patients. Methods Multicentre retrospective cohort study. Caudal sections of the thorax derived from abdominal contrast enhanced computed tomography (CECT) performed in the early phase of AP were assessed. Independent predictors of severe AP were identified by binary logistic regression analysis. A one-year survival analysis using Kaplan-Meier curves and log rank test was performed. Result 358 patients were analysed, finding pleuropulmonary pathologies in 81%. CECTs were performed with a median of 2 days (IQR 1-3) after admission. Multivariable analysis identified moderate to severe or bilateral pleural effusions (PEs) (OR = 4.16, 95%CI 2.05-8.45, p Conclusions Increasing awareness of the prognostic impact of large and bilateral PEs and pre-existing CLD could facilitate the identification of patients at high risk for severe AP in the early phase and thus improve their prognosis.
Subject: ORGAN FAILURE
PLEURAL EFFUSION
ASSOCIATION
MORTALITY
NECROSIS
DEATH
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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