Application of microfluidic chips in anticancer drug screening

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Fan , X , Deng , Z , Yan , Y , E. Orel , V , Shypko , A , B. Orel , V , Ivanova , D , Pilarsky , C , Tang , J , Chen , Z-S & Zhang , J 2022 , ' Application of microfluidic chips in anticancer drug screening ' , Bosnian Journal of Basic Medical Sciences , vol. 22 , no. 3 , pp. 302-314 . https://doi.org/10.17305/bjbms.2021.6484

Title: Application of microfluidic chips in anticancer drug screening
Author: Fan, Xin-yue; Deng, Zhuo-fen; Yan, Yan-yan; E. Orel, Valerii; Shypko, Andrii; B. Orel, Valerii; Ivanova, Donika; Pilarsky, Christian; Tang, Jing; Chen, Zhe-Sheng; Zhang, Jian-ye
Contributor organization: Medicum
Institute for Molecular Medicine Finland
Research Program in Systems Oncology
Date: 2022
Language: eng
Number of pages: 13
Belongs to series: Bosnian Journal of Basic Medical Sciences
ISSN: 1840-4812
DOI: https://doi.org/10.17305/bjbms.2021.6484
URI: http://hdl.handle.net/10138/346355
Abstract: With the continuous development of drug screening technology, new screening methodologies and technologies are constantly emerging, driving drug screening into rapid, efficient and high-throughput development. Microfluidics is a rising star in the development of innovative approaches in drug discovery. In this article, we summarize the recent years' progress of microfluidic chip technology in drug screening, including the developmental history, structural design, and applications in different aspects of microfluidic chips on drug screening. Herein, the existing microfluidic chip screening platforms are summarized from four aspects: chip structure design, sample injection and drive system, cell culture technology on a chip, and efficient remote detection technology. Furthermore, this review discusses the application and developmental prospects of using microfluidic chips in drug screening, particularly in screening natural product anticancer drugs based on chemical properties, pharmacological effects, and drug cytotoxicity.
Subject: 3122 Cancers
3111 Biomedicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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