Comprehensive genome-wide association study of different forms of hernia identifies more than 80 associated loci

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IPSYCH Grp , FinnGen Consortium , Fadista , J , Skotte , L , Karjalainen , J , Abner , E , Sorensen , E , Ullum , H , Werge , T , Esko , T , Milani , L , Palotie , A , Daly , M , Melbye , M , Feenstra , B & Geller , F 2022 , ' Comprehensive genome-wide association study of different forms of hernia identifies more than 80 associated loci ' , Nature Communications , vol. 13 , no. 1 , 3200 . https://doi.org/10.1038/s41467-022-30921-4

Title: Comprehensive genome-wide association study of different forms of hernia identifies more than 80 associated loci
Author: IPSYCH Grp; FinnGen Consortium; Fadista, Joao; Skotte, Line; Karjalainen, Juha; Abner, Erik; Sorensen, Erik; Ullum, Henrik; Werge, Thomas; Esko, Tonu; Milani, Lili; Palotie, Aarno; Daly, Mark; Melbye, Mads; Feenstra, Bjarke; Geller, Frank
Contributor organization: Institute for Molecular Medicine Finland
Helsinki Institute of Life Science HiLIFE
University of Helsinki
Centre of Excellence in Complex Disease Genetics
Research Programs Unit
Genomics of Neurological and Neuropsychiatric Disorders
Date: 2022-06-09
Language: eng
Number of pages: 11
Belongs to series: Nature Communications
ISSN: 2041-1723
DOI: https://doi.org/10.1038/s41467-022-30921-4
URI: http://hdl.handle.net/10138/346359
Abstract: Hernias are characterized by protrusion of an organ or tissue through its surrounding cavity and often require surgical repair. In this study we identify 65,492 cases for five hernia types in the UK Biobank and perform genome-wide association study scans for these five types and two combined groups. Our results show associated variants in all scans. Inguinal hernia has the most associations and we conduct a follow-up study with 23,803 additional cases from four study groups giving 84 independently associated variants. Identified variants from all scans are collapsed into 81 independent loci. Further testing shows that 26 loci are associated with more than one hernia type, suggesting substantial overlap between the underlying genetic mechanisms. Pathway analyses identify several genes with a strong link to collagen and/or elastin (ADAMTS6, ADAMTS16, ADAMTSL3, LOX, ELN) in the vicinity of associated loci for inguinal hernia, which substantiates an essential role of connective tissue morphology. Hernias involve protrusion of an organ or tissue through its surrounding cavity. Here the authors carry out GWAS for five types of hernia and find 81 variants, most of which are associated with inguinal hernia; downstream analysis suggests an important role for connective tissue morphology.
Subject: LD SCORE REGRESSION
MENDELIAN RANDOMIZATION
INGUINAL-HERNIA
HAPLOTYPE
INFERENCE
GENOTYPE
3111 Biomedicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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