Anand , S , Pakkasjärvi , N , Bajpai , M , Krishnan , N , Goswami , C , Suominen , J S , Yadav , D K & Goel , P 2022 , ' Utility of Pentraxin-3 as a biomarker for diagnosis of acute appendicitis : a systematic review and meta-analysis ' , Pediatric Surgery International , vol. 38 , no. 8 , pp. 1105-1112 . https://doi.org/10.1007/s00383-022-05149-4
Title: | Utility of Pentraxin-3 as a biomarker for diagnosis of acute appendicitis : a systematic review and meta-analysis |
Author: | Anand, Sachit; Pakkasjärvi, Niklas; Bajpai, Minu; Krishnan, Nellai; Goswami, Chandramouli; Suominen, Janne S.; Yadav, Devendra Kumar; Goel, Prabudh |
Contributor organization: | Faculty of Medicine University of Helsinki HUS Children and Adolescents Lastenkirurgian yksikkö Clinicum Children's Hospital |
Date: | 2022-08 |
Language: | eng |
Number of pages: | 8 |
Belongs to series: | Pediatric Surgery International |
ISSN: | 0179-0358 |
DOI: | https://doi.org/10.1007/s00383-022-05149-4 |
URI: | http://hdl.handle.net/10138/346362 |
Abstract: | Purpose To systematically summarize all relevant data and to define the current evidence on the utility of Pentraxin-3 (PTX3) as a biomarker for acute appendicitis (AA) in children. Methods This review was conducted in accordance with the PRISMA guidelines. PubMed, Embase, Scopus, and Web of Science databases were systematically searched for studies comparing the levels of PTX3 in patients with AA vs healthy controls or non-specific abdominal pain (NSAP). Mean differences were calculated for all outcomes and the inverse variance method was used for weighted mean difference. The methodological quality of the included studies was assessed using the Downs and Black scale. Results Five comparative studies were included. Significantly elevated levels of PTX3 in cases with AA vs healthy controls (WMD: 9.56, 95% CI 7.24-11.88, p < 0.00001), and patients with AA vs NSAP (WMD: 8.05, 95% CI 6.81-9.29, p < 0.00001) were demonstrated. Similarly, in separate meta-analyses, the levels of PTX3 were significantly elevated in children with AA vs healthy controls (WMD: 11.18, 95% CI 10.03-12.34, p < 0.00001), and children with AA vs NSAP (WMD: 8.35, 95% CI 6.88-9.82, p < 0.00001). Conclusions PTX3-levels are elevated in AA, but differentiation between perforated and non-perforated appendicitis demands other methods. |
Subject: |
Pentraxin-3
Acute phase protein Biomarker Acute appendicitis Complicated appendicitis Perforated appendicitis Non-specific abdominal pain Children LONG PENTRAXIN PTX3 3123 Gynaecology and paediatrics 3126 Surgery, anesthesiology, intensive care, radiology |
Peer reviewed: | Yes |
Rights: | cc_by |
Usage restriction: | openAccess |
Self-archived version: | publishedVersion |
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