Utility of Pentraxin-3 as a biomarker for diagnosis of acute appendicitis : a systematic review and meta-analysis

Show full item record



Permalink

http://hdl.handle.net/10138/346362

Citation

Anand , S , Pakkasjärvi , N , Bajpai , M , Krishnan , N , Goswami , C , Suominen , J S , Yadav , D K & Goel , P 2022 , ' Utility of Pentraxin-3 as a biomarker for diagnosis of acute appendicitis : a systematic review and meta-analysis ' , Pediatric Surgery International , vol. 38 , no. 8 , pp. 1105-1112 . https://doi.org/10.1007/s00383-022-05149-4

Title: Utility of Pentraxin-3 as a biomarker for diagnosis of acute appendicitis : a systematic review and meta-analysis
Author: Anand, Sachit; Pakkasjärvi, Niklas; Bajpai, Minu; Krishnan, Nellai; Goswami, Chandramouli; Suominen, Janne S.; Yadav, Devendra Kumar; Goel, Prabudh
Contributor organization: Faculty of Medicine
University of Helsinki
HUS Children and Adolescents
Lastenkirurgian yksikkö
Clinicum
Children's Hospital
Date: 2022-08
Language: eng
Number of pages: 8
Belongs to series: Pediatric Surgery International
ISSN: 0179-0358
DOI: https://doi.org/10.1007/s00383-022-05149-4
URI: http://hdl.handle.net/10138/346362
Abstract: Purpose To systematically summarize all relevant data and to define the current evidence on the utility of Pentraxin-3 (PTX3) as a biomarker for acute appendicitis (AA) in children. Methods This review was conducted in accordance with the PRISMA guidelines. PubMed, Embase, Scopus, and Web of Science databases were systematically searched for studies comparing the levels of PTX3 in patients with AA vs healthy controls or non-specific abdominal pain (NSAP). Mean differences were calculated for all outcomes and the inverse variance method was used for weighted mean difference. The methodological quality of the included studies was assessed using the Downs and Black scale. Results Five comparative studies were included. Significantly elevated levels of PTX3 in cases with AA vs healthy controls (WMD: 9.56, 95% CI 7.24-11.88, p < 0.00001), and patients with AA vs NSAP (WMD: 8.05, 95% CI 6.81-9.29, p < 0.00001) were demonstrated. Similarly, in separate meta-analyses, the levels of PTX3 were significantly elevated in children with AA vs healthy controls (WMD: 11.18, 95% CI 10.03-12.34, p < 0.00001), and children with AA vs NSAP (WMD: 8.35, 95% CI 6.88-9.82, p < 0.00001). Conclusions PTX3-levels are elevated in AA, but differentiation between perforated and non-perforated appendicitis demands other methods.
Subject: Pentraxin-3
Acute phase protein
Biomarker
Acute appendicitis
Complicated appendicitis
Perforated appendicitis
Non-specific abdominal pain
Children
LONG PENTRAXIN
PTX3
3123 Gynaecology and paediatrics
3126 Surgery, anesthesiology, intensive care, radiology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


Files in this item

Total number of downloads: Loading...

Files Size Format View
Anand2022_Artic ... fPentraxin_3AsABiomark.pdf 930.5Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record