Association of Renal Glomerular and Tubular Function With Renal Outcome in Patients With Posterior Urethral Valves

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Heikkilä , J , Jahnukainen , T , Holmberg , C & Taskinen , S 2021 , ' Association of Renal Glomerular and Tubular Function With Renal Outcome in Patients With Posterior Urethral Valves ' , Urology , vol. 153 , pp. 285-290 . https://doi.org/10.1016/j.urology.2020.11.045

Title: Association of Renal Glomerular and Tubular Function With Renal Outcome in Patients With Posterior Urethral Valves
Author: Heikkilä, Jukka; Jahnukainen, Timo; Holmberg, Christer; Taskinen, Seppo
Contributor organization: Children's Hospital
HUS Children and Adolescents
Lastenkirurgian yksikkö
Lastentautien yksikkö
Clinicum
Date: 2021-07
Language: eng
Number of pages: 6
Belongs to series: Urology
ISSN: 0090-4295
DOI: https://doi.org/10.1016/j.urology.2020.11.045
URI: http://hdl.handle.net/10138/346373
Abstract: OBJECTIVE To analyze renal glomerular and tubular function and their association in patients operated for posterior urethral valves and to prognosticate the risk for end-stage kidney disease (ESKD) METHODS Sixty-three previously treated patients were evaluated for renal function during 1987-1991. The patients' age at evaluation was 11 years (range 2-24). Glomerular function was assessed by measuring glomerular filtration rate (GFR) and urine albumin excretion. Tubular function was determined by measuring urine concentration capacity and excretion of electrolytes (Na, K, Cl, Ca, P, Mg) and 0-2-microglobulin. Additionally, the prevalence of hypertension and serum parathyroid hormone and aldosterone values were registered. Tubular function was compared with GFR and the risk of developing ESKD before November 2018. RESULTS Twenty of the study patients (32%) had decreased GFR. In addition, 19% had proteinuria and 56% were hypertensive. Those without proteinuria or hypertension had better GFR values (P < .01 for both). There was a significant correlation between GFR and all the tubular function (P < .05) variables (except excretion of chloride) measured. Compared to the patients with favorable renal outcome, the patients (n = 10) who later developed ESKD had significantly (P < .01) lower GFR and reduced urinary excretion of all measured electrolytes except calcium. Consistently, urine 0-2 microglobulin and serum parathyroid hormone and aldosterone values were significantly higher in the patients who developed ESKD (P CONCLUSION Both glomerular and tubular function decline was common and several parameters were likely to predict ESKD in posterior urethral valves patients. UROLOGY (C) 2020 Elsevier Inc.
Subject: RISK-FACTORS
CHILDREN
PROGRESSION
DISEASE
MANAGEMENT
GUIDELINE
POLYURIA
RENIN
3123 Gynaecology and paediatrics
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: draft


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