Robust prognostic model based on immune infiltration-related genes and clinical information in ovarian cancer

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Zhang , X , Kong , W , Gao , M , Huang , W , Peng , C , Huang , Z , Xie , Z & Guo , H 2022 , ' Robust prognostic model based on immune infiltration-related genes and clinical information in ovarian cancer ' , Journal of Cellular and Molecular Medicine , vol. 26 , no. 13 , pp. 3659-3674 . https://doi.org/10.1111/jcmm.17360

Title: Robust prognostic model based on immune infiltration-related genes and clinical information in ovarian cancer
Author: Zhang, Xi; Kong, Weikaixin; Gao, Miaomiao; Huang, Weiran; Peng, Chao; Huang, Zhuo; Xie, Zhengwei; Guo, Hongyan
Contributor organization: Institute for Molecular Medicine Finland
Date: 2022-07
Language: eng
Number of pages: 16
Belongs to series: Journal of Cellular and Molecular Medicine
ISSN: 1582-1838
DOI: https://doi.org/10.1111/jcmm.17360
URI: http://hdl.handle.net/10138/346376
Abstract: Immune infiltration of ovarian cancer (OV) is a critical factor in determining patient's prognosis. Using data from TCGA and GTEx database combined with WGCNA and ESTIMATE methods, 46 genes related to OV occurrence and immune infiltration were identified. Lasso and multivariate Cox regression were applied to define a prognostic score (IGCI score) based on 3 immune genes and 3 types of clinical information. The IGCI score has been verified by K-M curves, ROC curves and C-index on test set. In test set, IGCI score (C-index = 0.630) is significantly better than AJCC stage (C-index = 0.541, p < 0.05) and CIN25 (C-index = 0.571, p < 0.05). In addition, we identified key mutations to analyse prognosis of patients and the process related to immunity. Chi-squared tests revealed that 6 mutations are significantly (p < 0.05) related to immune infiltration: BRCA1, ZNF462, VWF, RBAK, RB1 and ADGRV1. According to mutation survival analysis, we found 5 key mutations significantly related to patient prognosis (p < 0.05): CSMD3, FLG2, HMCN1, TOP2A and TRRAP. RB1 and CSMD3 mutations had small p-value (p < 0.1) in both chi-squared tests and survival analysis. The drug sensitivity analysis of key mutation showed when RB1 mutation occurs, the efficacy of six anti-tumour drugs has changed significantly (p < 0.05).
Subject: immune infiltration
nomogram
Ovarian cancer
prognosis
DNA-REPAIR
SOMATIC MUTATIONS
EXPRESSION
CARCINOMA
THERAPY
TARGETS
IDENTIFICATION
INACTIVATION
INDUCTION
MICRORNA
1182 Biochemistry, cell and molecular biology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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