Torque Teno Virus Primary Infection Kinetics in Early Childhood

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Väisänen , E , Kuisma , I , Mäkinen , M , Ilonen , J , Veijola , R , Toppari , J , Hedman , K & Söderlund-Venermo , M 2022 , ' Torque Teno Virus Primary Infection Kinetics in Early Childhood ' , Viruses (Basel) , vol. 14 , no. 6 , 1277 . https://doi.org/10.3390/v14061277

Title: Torque Teno Virus Primary Infection Kinetics in Early Childhood
Author: Väisänen, Elina; Kuisma, Inka; Mäkinen, Marjaana; Ilonen, Jorma; Veijola, Riitta; Toppari, Jorma; Hedman, Klaus; Söderlund-Venermo, Maria
Contributor organization: Department of Virology
Human Parvoviruses: Epidemiology, Molecular Biology and Clinical Impact
University of Helsinki
Medicum
HUSLAB
Virus infections and immunity
Klaus Hedman / Principal Investigator
Biosciences
Date: 2022-06
Language: eng
Number of pages: 10
Belongs to series: Viruses (Basel)
ISSN: 1999-4915
DOI: https://doi.org/10.3390/v14061277
URI: http://hdl.handle.net/10138/346401
Abstract: Human torque teno viruses (TTVs) are a diverse group of small nonenveloped viruses with circular, single-stranded DNA genomes. These elusive anelloviruses are harbored in the blood stream of most humans and have thus been considered part of the normal flora. Whether the primary infection as a rule take(s) place before or after birth has been debated. The aim of our study was to determine the time of TTV primary infection and the viral load and strain variations during infancy and follow-up for up to 7 years. TTV DNAs were quantified in serial serum samples from 102 children by a pan-TTV quantitative PCR, and the amplicons from representative time points were cloned and sequenced to disclose the TTV strain diversity. We detected an unequivocal rise in TTV-DNA prevalence, from 39% at 4 months of age to 93% at 2 years; all children but one, 99%, became TTV-DNA positive before age 4 years. The TTV-DNA quantities ranged from 5 x 10(1) to 4 x 10(7) copies/mL, both within and between the children. In conclusion, TTV primary infections occur mainly after birth, and increase during the first two years with high intra- and interindividual variation in both DNA quantities and virus strains.
Subject: anellovirus
TTV primary infection
infants
genoprevalence
viremia
TT VIRUS
HUMAN VIROME
TRANSMISSION
COINFECTION
CHILDREN
DISEASE
3111 Biomedicine
11832 Microbiology and virology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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