Elevated One-Hour Post-Load Glucose Is Independently Associated with Albuminuria: A Cross-Sectional Population Study

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Saunajoki, A.; Auvinen, J.; Bloigu, A.; Saramies, J.; Tuomilehto, J.; Uusitalo, H.; Hussi, E.; Cederberg-Tamminen, H.; Suija, K.; Keinänen-Kiukaanniemi, S.; Timonen, M. Elevated One-Hour Post-Load Glucose Is Independently Associated with Albuminuria: A Cross-Sectional Population Study. J. Clin. Med. 2022, 11, 4124.

Title: Elevated One-Hour Post-Load Glucose Is Independently Associated with Albuminuria: A Cross-Sectional Population Study
Author: Saunajoki, Anni; Auvinen, Juha; Bloigu, Aini; Saramies, Jouko; Tuomilehto, Jaakko; Uusitalo, Hannu; Hussi, Esko; Cederberg-Tamminen, Henna; Suija, Kadri; Keinänen-Kiukaanniemi, Sirkka; Timonen, Markku
Publisher: Multidisciplinary Digital Publishing Institute
Date: 2022-07-15
URI: http://hdl.handle.net/10138/346419
Abstract: The purpose of this study was to examine and compare the associations between albuminuria and fasting (FPG), 1 h post-load (1 h PG) and 2 h post-load plasma glucose (2 h PG) in an oral glucose tolerance test (OGTT). A total of 496 people free of known diabetes (mean age 72 years) participated in the examinations including the OGTT with plasma glucose measurements at 0, 1, and 2 h and levels of HbA1c. Albuminuria was determined by the urinary albumin-to-creatinine ratio and was defined as ≥3.0 mg/mmol. Compared with those without albuminuria, participants with albuminuria had significantly higher 1 h PG and 2 h PG levels, but not FPG or HbA1c levels. An elevated 1 h PG increased the estimated odds ratio of albuminuria more than three times in people with prediabetic 1 h PG (8.6–11.5 mmol/L: OR 3.60; 95% CI 1.70–7.64) and diabetic 1 h PG (≥11.6 mmol/L: OR 3.05; 95% CI 1.29–7.23). After adjusting for blood pressure and age, the association of elevated 1 h PG with albuminuria remained significant. Prediabetic or diabetic FPG, 2 h PG, or HbA1c did not have a statistically significant association with albuminuria. These findings suggest that 1 h PG seems to be the best glycemic parameter and is useful in recognizing persons with an elevated risk of early kidney disease due to hyperglycemia.


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