Oxytocin receptor genotype moderates the association between maternal prenatal stress and infant early self-regulation

Show full item record



Permalink

http://hdl.handle.net/10138/346455

Citation

Kajanoja , J , Nolvi , S , Kantojärvi , K , Karlsson , L , Paunio , T & Karlsson , H 2022 , ' Oxytocin receptor genotype moderates the association between maternal prenatal stress and infant early self-regulation ' , Psychoneuroendocrinology , vol. 138 , 105669 . https://doi.org/10.1016/j.psyneuen.2022.105669

Title: Oxytocin receptor genotype moderates the association between maternal prenatal stress and infant early self-regulation
Author: Kajanoja, Jani; Nolvi, Saara; Kantojärvi, Katri; Karlsson, Linnea; Paunio, Tiina; Karlsson, Hasse
Contributor organization: SLEEPWELL Research Program
Clinicum
HUS Psychiatry
Department of Psychiatry
University of Helsinki
Date: 2022-04
Language: eng
Number of pages: 7
Belongs to series: Psychoneuroendocrinology
ISSN: 0306-4530
DOI: https://doi.org/10.1016/j.psyneuen.2022.105669
URI: http://hdl.handle.net/10138/346455
Abstract: Introduction: Maternal prenatal stress may have long-term adverse consequences for child development. Accumulating evidence shows that the oxytocin-receptor genotype may play a role in differential susceptibility to early-life adversity, but no studies have examined whether this moderation extends to the prenatal stress exposures. Methods: In the FinnBrain Birth Cohort Study, a sample of 1173 mother-child dyads were examined. We studied the possible moderating effect of the cumulative effect of infant oxytocin-receptor risk genotypes (rs53576GG and rs2254298A) in the association between maternal prenatal stress, and infant negative reactivity and emerging self-regulation at 6 months of age. Results: The number of OTr risk genotypes moderated the association between maternal prenatal anxiety and infant self-regulation, implying a cumulative effect of genotype, although effects sizes were small. In infants with two risk genotypes, a negative association between prenatal anxiety and self-regulation was observed, whereas in infants with one or no risk genotypes, the association between maternal prenatal anxiety and temperament was non-significant. Conclusion: Oxytocin-receptor genotype may moderate the association of maternal stress during pregnancy and child social-emotional development. Possible mechanisms for this moderation effect are discussed. Further studies with a more comprehensive polygenic approach are needed to confirm these results.
Subject: Oxytocin
Self-regulation
Temperament
Prenatal stress
GENE OXTR METHYLATION
DIFFERENTIAL SUSCEPTIBILITY
EARLY-LIFE
DNA METHYLATION
CHILD OUTCOMES
MENTAL-HEALTH
ANXIETY
BRAIN
PREGNANCY
BEHAVIOR
3112 Neurosciences
3124 Neurology and psychiatry
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


Files in this item

Total number of downloads: Loading...

Files Size Format View
1_s2.0_S0306453022000105_main.pdf 897.5Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record