In bronchiectasis, poor physical capacity correlates with poor quality of life

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Mäntylä , J , Mazur , W , Törölä , T , Bergman , P & Kauppi , P 2022 , ' In bronchiectasis, poor physical capacity correlates with poor quality of life ' , European Clinical Respiratory Journal , vol. 9 , no. 1 , 2095104 . https://doi.org/10.1080/20018525.2022.2095104

Title: In bronchiectasis, poor physical capacity correlates with poor quality of life
Author: Mäntylä, Jarkko; Mazur, Witold; Törölä, Tanja; Bergman, Paula; Kauppi, Paula
Contributor organization: HUS Heart and Lung Center
Department of Medicine
Keuhkosairauksien yksikkö
Clinicum
University of Helsinki
HUS Inflammation Center
Department of Dermatology, Allergology and Venereology
Department of Public Health
Date: 2022-12-31
Language: eng
Number of pages: 7
Belongs to series: European Clinical Respiratory Journal
ISSN: 2001-8525
DOI: https://doi.org/10.1080/20018525.2022.2095104
URI: http://hdl.handle.net/10138/346458
Abstract: Purpose Patients with bronchiectasis (BE) who suffer frequent exacerbations are likely to experience negative effects on quality of life (QoL) and require more healthcare utilization. We aimed to discover, in a cohort of Finnish BE patients, those risk factors that influence QoL. Methods Non-cystic fibrosis BE patients of a Helsinki University Hospital cohort were examined with high-resolution computed tomography (HRCT) of the chest. They completed a disease-specific quality of life-bronchiectasis (QoL-B) questionnaire in Finnish translation. We considered scores in the lowest quarter (25%) of that QoL-B scale to indicate poor QoL. The bronchiectasis severity index (BSI), FACED score, and modified Medical Research Council (mMRC) dyspnoea scale were used. Results Overall, of 95 adult BE patients, mean age was 69 (SD +/- 13) and 79% were women. From the cohort, 82% presented with chronic sputum production and exacerbations, at a median rate of 1.7 (SD +/- 1.6). The number of exacerbations (OR 1.7), frequent exacerbations (>= 3 per year) (OR 4.9), high BSI score (OR 1.3), and extensive disease (>= 3 lobes) (OR 3.7) were all predictive of poor QoL. Frequent exacerbations were associated with bronchial bacterial colonisation, low forced expiratory volume in 1 s (FEV1), and radiological disease severity. Based on the BSI, 34.1% of our cohort had severe disease, with 11.6% classified as severe according to their FACED score. The mMRC dyspnoea score (r = -0.57) and BSI (r = -0.60) correlated, in the QoL-B questionnaire, negatively with physical domain. Conclusion The strongest determinants of poor QoL in the cohort of Finnish BE patients were frequent exacerbations, radiological disease severity, and high BSI score. Neither comorbidities nor BE aetiology appeared to affect QoL. Reduced physical capacity correlated with dyspnoea and severe disease. Study registration University of Helsinki, Faculty of Medicine, 148/16.08.2017.
Subject: Bronchiectasis
bronchiectasis severity index
quality of life
extensive disease
exacerbation
SEVERITY INDEX
QUESTIONNAIRE
VALIDATION
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by_nc
Usage restriction: openAccess
Self-archived version: publishedVersion


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