Obstetric and perinatal risks after the use of donor sperm : A systematic review and meta-analysis

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Pohjonen , E M , Söderström-Anttila , V , Bergh , C , Loft , A , Magnusson , A , Pinborg , A , Oldereid , N B , Petzold , M , Romundstad , L B & Laivuori , H 2022 , ' Obstetric and perinatal risks after the use of donor sperm : A systematic review and meta-analysis ' , European Journal of Obstetrics, and Gynecology ,and Reproductive Biology , vol. 274 , pp. 210-228 . https://doi.org/10.1016/j.ejogrb.2022.05.031

Title: Obstetric and perinatal risks after the use of donor sperm : A systematic review and meta-analysis
Author: Pohjonen, E. M.; Söderström-Anttila, V.; Bergh, C.; Loft, A.; Magnusson, A.; Pinborg, A.; Oldereid, N. B.; Petzold, M.; Romundstad, L. B.; Laivuori, H.
Contributor organization: Clinicum
HUS Gynecology and Obstetrics
Genomics of Neurological and Neuropsychiatric Disorders
Institute for Molecular Medicine Finland
University of Helsinki
Helsinki Institute of Life Science HiLIFE
Date: 2022-07
Language: eng
Number of pages: 19
Belongs to series: European Journal of Obstetrics, and Gynecology ,and Reproductive Biology
ISSN: 0301-2115
DOI: https://doi.org/10.1016/j.ejogrb.2022.05.031
URI: http://hdl.handle.net/10138/346465
Abstract: Donor sperm is widely used in infertility treatments. The purpose of the study was to investigate, whether use of donor sperm in intrauterine insemination (IUI) or in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatments affect maternal and perinatal risks compared with spontaneously conceived pregnancies or use of partner sperm in IUI, IVF or ICSI. We provide a systematic review and meta-analyses on the most clinically relevant obstetric and perinatal outcomes after use of donor sperm compared with partner sperm: hypertensive disorders of pregnancy, preeclampsia, low birth weight, and preterm birth. Our meta-analyses showed an increased risk for preeclampsia (pooled adjusted odds ratio (aOR) 1.77, 95% CI 1.26-2.48) and hypertensive disorders of pregnancy (pooled aOR 1.55, 95%, CI 1.20-2.00) in pregnancies resulting from IUI with donor sperm compared with IUI with partner sperm. No increased risk was seen for low birth weight or preterm birth after the use of donor sperm in IUI compared with the use of partner sperm in IUI. Subgroup analysis for singletons only did not change these results. The meta-analysis on low birth weight showed a lower risk after in IVF with donor sperm compared with IVF with partner sperm (pooled aOR 0.89, 95% CI 0.83-0.94). For hypertensive disorders of pregnancy, preeclampsia and preterm birth, no difference was found between IVF with donor sperm vs. partner sperm. Patients need to be informed about the moderately increased risk of hypertensive disorders of pregnancy and preeclampsia in pregnancies after IUI with donor sperm.
Subject: Donor insemination
Donor sperm
Preeclampsia
Hypertensive disorders of pregnancy
Perinatal outcome
ASSISTED-REPRODUCTIVE-TECHNOLOGIES
ADVERSE PREGNANCY OUTCOMES
ADVANCED MATERNAL AGE
INTRAUTERINE INSEMINATION
ARTIFICIAL-INSEMINATION
HYPERTENSIVE DISORDERS
OFFSPRING HEALTH
PARTNER SPERM
SINGLE WOMEN
PREECLAMPSIA
3123 Gynaecology and paediatrics
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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