Ultra-high frequency ultrasound delineated changes in carotid and muscular artery intima-media and adventitia thickness in obese early middle-aged women

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Sundholm , J K M , Litwin , L , Rönö , K , Koivusalo , S B , Eriksson , J G & Sarkola , T 2022 , ' Ultra-high frequency ultrasound delineated changes in carotid and muscular artery intima-media and adventitia thickness in obese early middle-aged women ' , Diabetes and Vascular Disease Research , vol. 19 , no. 3 , 14791641221094321 . https://doi.org/10.1177/14791641221094321

Title: Ultra-high frequency ultrasound delineated changes in carotid and muscular artery intima-media and adventitia thickness in obese early middle-aged women
Author: Sundholm, Johnny K. M.; Litwin, Linda; Rönö, Kristiina; Koivusalo, Saila B.; Eriksson, Johan G.; Sarkola, Taisto
Contributor organization: HUS Children and Adolescents
Children's Hospital
University of Helsinki
Department of Obstetrics and Gynecology
Clinicum
HUS Gynecology and Obstetrics
Research Programs Unit
Johan Eriksson / Principal Investigator
Department of General Practice and Primary Health Care
Date: 2022-05
Language: eng
Number of pages: 12
Belongs to series: Diabetes and Vascular Disease Research
ISSN: 1479-1641
DOI: https://doi.org/10.1177/14791641221094321
URI: http://hdl.handle.net/10138/346468
Abstract: Obesity is linked to increased arterial size, carotid intima-media thickness and arterial stiffness. The effects of obesity and body composition on muscular artery intima-media and adventitia thickness has previously not been established. The aim of this study was to explore associations between carotid and muscular artery wall layer thickness with body composition and cardiovascular risk factors in early middle-aged women. This is a cross-sectional study including 199 women aged 40 +/- 4 years. Arterial lumen (LD), intima-media (IMT) and adventitia thickness (AT) were measured from carotid, brachial and radial arteries using ultra-high frequency ultrasound (22-71 MHz). Women with obesity had increased IMT in carotid (0.47 vs 0.45 mm), brachial (0.19 vs 0.17 mm) and radial arteries (0.16 vs 0.15 mm) and increased brachial AT (0.14 vs 0.13 mm). In multiple regression models all arterial LD (beta-range 0.02-0.03 mm/kg/m(2)), IMT (beta-range 0.91-3.37 mu m/kg/m(2)), AT (beta-range 0.73-1.38 mu m/kg/m(2)) were significantly associated with BMI. The IMT of all arteries were significantly associated with systolic blood pressure (beta-range 0.36-0.85 mu m/mmHg), attenuating the association between IMT and BMI (beta-range 0.18-2.24 mu m/kg/m(2)). Obese early middle-aged women have increased arterial intima media thickness and brachial artery adventitia thickness compared to non-obese counterparts. The association between BMI and intima-media thickness is partly mediated through blood pressure levels.
Subject: Obesity
arterial stiffness
intima-media thickness
adventitia thickness
ultra-high frequency ultrasound
CARDIOVASCULAR EVENTS
INSULIN-RESISTANCE
BRACHIAL-ARTERY
RADIAL ARTERY
BODY-MASS
STIFFNESS
DIAMETER
3RD
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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