Cortical beta burst dynamics are altered in Parkinson's disease but normalized by deep brain stimulation

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Pauls , K A M , Korsun , O , Nenonen , J , Nurminen , J , Liljeström , M , Kujala , J , Pekkonen , E & Renvall , H 2022 , ' Cortical beta burst dynamics are altered in Parkinson's disease but normalized by deep brain stimulation ' , NeuroImage , vol. 257 , 119308 . https://doi.org/10.1016/j.neuroimage.2022.119308

Title: Cortical beta burst dynamics are altered in Parkinson's disease but normalized by deep brain stimulation
Author: Pauls, K. Amande M.; Korsun, Olesia; Nenonen, Jukka; Nurminen, Jussi; Liljeström, Mia; Kujala, Jan; Pekkonen, Eero; Renvall, Hanna
Contributor organization: Faculty Common Matters (Faculty of Medicine)
Faculty Common Matters (Faculty of Biology and Environmental Sciences)
BioMag Laboratory
Neurologian yksikkö
HUS Neurocenter
Department of Neurosciences
Clinicum
University of Helsinki
HUS Medical Imaging Center
Date: 2022-08-15
Language: eng
Number of pages: 11
Belongs to series: NeuroImage
ISSN: 1053-8119
DOI: https://doi.org/10.1016/j.neuroimage.2022.119308
URI: http://hdl.handle.net/10138/346469
Abstract: Exaggerated subthalamic beta oscillatory activity and increased beta range cortico-subthalamic synchrony have crystallized as the electrophysiological hallmarks of Parkinson's disease. Beta oscillatory activity is not tonic but occurs in 'bursts' of transient amplitude increases. In Parkinson's disease, the characteristics of these bursts are altered especially in the basal ganglia. However, beta oscillatory dynamics at the cortical level and how they compare with healthy brain activity is less well studied. We used magnetoencephalography (MEG) to study sensorimotor cortical beta bursting and its modulation by subthalamic deep brain stimulation in Parkinson's disease patients and age-matched healthy controls. We show that the changes in beta bursting amplitude and duration typical of Parkinson's disease can also be observed in the sensorimotor cortex, and that they are modulated by chronic subthalamic deep brain stimulation, which, in turn, is reflected in improved motor function at the behavioural level. In addition to the changes in individual beta bursts, their timing relative to each other was altered in patients compared to controls: bursts were more clustered in untreated Parkinson's disease, occurring in 'bursts of bursts', and re-burst probability was higher for longer compared to shorter bursts. During active deep brain stimulation, the beta bursting in patients resembled healthy controls' data. In summary, both individual bursts' characteristics and burst patterning are affected in Parkinson's disease, and subthalamic deep brain stimulation normalizes some of these changes to resemble healthy controls' beta bursting activity, suggesting a non-invasive biomarker for patient and treatment follow-up.
Subject: Parkinson?s disease
Magnetoencephalography
Beta burst
Deep brain stimulation
Oscillatory activity
Resting state
SIGNAL SPACE SEPARATION
SUBTHALAMIC NUCLEUS
FREQUENCY ACTIVITY
MOTOR CORTEX
SYNCHRONIZATION
OSCILLATIONS
ATTENTION
DOPAMINE
MODULATION
STATE
3112 Neurosciences
3124 Neurology and psychiatry
3126 Surgery, anesthesiology, intensive care, radiology
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: publishedVersion


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