Elevated highly sensitive C-reactive protein in fibromyalgia associates with symptom severity

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Zetterman , T , Markkula , R & Kalso , E 2022 , ' Elevated highly sensitive C-reactive protein in fibromyalgia associates with symptom severity ' , Rheumatology Advances in Practice , vol. 6 , no. 2 , 053 . https://doi.org/10.1093/rap/rkac053

Title: Elevated highly sensitive C-reactive protein in fibromyalgia associates with symptom severity
Author: Zetterman, Teemu; Markkula, Ritva; Kalso, Eija
Contributor organization: Department of General Practice and Primary Health Care
University of Helsinki
HUS Perioperative, Intensive Care and Pain Medicine
Anestesiologian yksikkö
Eija Kalso / Principal Investigator
Department of Diagnostics and Therapeutics
SLEEPWELL Research Program
Date: 2022-05-06
Language: eng
Number of pages: 13
Belongs to series: Rheumatology Advances in Practice
ISSN: 2514-1775
DOI: https://doi.org/10.1093/rap/rkac053
URI: http://hdl.handle.net/10138/346498
Abstract: Objectives. Fibromyalgia (FM), a common pain syndrome, is thought to be a non-inflammatory, nociplastic condition, but evidence implicating neuroinflammation has been increasing. Systemic inflammation may be associated with more severe symptoms in some FM patients. We studied healthy controls and FM patients with and without systemic inflammation detectable using high-sensitivity CRP (hsCRP) measurement. Methods. We measured hsCRP levels and gathered clinical and questionnaire data [including the Fibromyalgia Impact Questionnaire (FIQ)] from 40 female FM patients and 30 age-matched healthy women. An hsCRP level >3 mg/l was considered elevated. Results. FM patients had significantly higher mean hsCRP levels than controls, explained by overweight and lower leisure-time physical activity. Eight FM patients had elevated hsCRP levels and 29 had normal hsCRP levels. Levels of hsCRP were significantly correlated with FIQ scores. Patients with elevated hsCRP had higher FIQ scores, with worse physical functioning and greater pain and were less likely to be employed than patients with normal hsCRP. These patient groups did not differ by blood count, liver function or lipid profiles, nor by education, psychological measures, sleep disturbance, smoking or comorbidities. Conclusion. Some FM patients have elevated hsCRP, mostly due to overweight and physical inactivity. They have worse symptoms and their ability to work is impaired. Measurement of hsCRP may help to identify FM patients in greatest need of interventions supporting working ability.
Subject: FM
widespread pain
chronic pain
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion

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