Searching for a paternal phenotype for preeclampsia

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FINNPEC , Jaatinen , N , Jääskeläinen , T , Ekholm , E & Laivuori , H 2022 , ' Searching for a paternal phenotype for preeclampsia ' , Acta Obstetricia et Gynecologica Scandinavica , vol. 101 , no. 8 , pp. 862-870 . https://doi.org/10.1111/aogs.14388

Title: Searching for a paternal phenotype for preeclampsia
Author: FINNPEC; Jaatinen, Noora; Jääskeläinen, Tiina; Ekholm, Eeva; Laivuori, Hannele
Contributor organization: HUS Gynecology and Obstetrics
Department of Obstetrics and Gynecology
Department of Food and Nutrition
Pregnancy and Genes
Medicum
Department of Medical and Clinical Genetics
Genomics of Neurological and Neuropsychiatric Disorders
Institute for Molecular Medicine Finland
University of Helsinki
Date: 2022-08
Language: eng
Number of pages: 9
Belongs to series: Acta Obstetricia et Gynecologica Scandinavica
ISSN: 0001-6349
DOI: https://doi.org/10.1111/aogs.14388
URI: http://hdl.handle.net/10138/346500
Abstract: Introduction Preeclampsia (PE) is a heterogeneous disorder and research to date has principally focused on maternal factors. In this study, however, we considered the associations between background factors and preeclampsia in men who fathered preeclamptic and non-preeclamptic pregnancies. Material and methods From 2008 to 2011, participants in the Finnish Genetics of Pre-eclampsia Consortium (FINNPEC) cohort completed a questionnaire on their background information. Questionnaire data were available from 586 men who had fathered a preeclamptic pregnancy (PE fathers) and 660 control men who had fathered a non-preeclamptic pregnancy. Two different control groups were established: Group 1: healthy controls (n = 457), which consisted of fathers whose current partners were healthy women with uncomplicated pregnancies; Group 2: other controls (n = 203), which also included fathers whose current partners had other pregnancy complications. Results The PE fathers more often reported preeclampsia in a previously fathered pregnancy (p < 0.05 for all). The PE and control fathers were similar in age, body mass index, smoking, and preexisting medical conditions. There were no differences in the socioeconomic background or health history of the PE and control fathers or their parents. Conclusions In the FINNPEC study cohort, the occurrence of preeclampsia in a previously fathered pregnancy was more common among the men who had fathered a preeclamptic pregnancy; other paternal phenotypic and lifestyle characteristics did not play a significant role in preeclampsia susceptibility of their partners.
Subject: lifestyle
paternal
phenotype
preeclampsia
pregnancy
pregnancy complication
risk factor
HYPERTENSIVE DISORDERS
RISK-FACTOR
FETAL
PREDISPOSITION
COMPONENTS
PREGNANCY
ECLAMPSIA
GENETICS
DISEASE
3123 Gynaecology and paediatrics
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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