Laurikka , P , Kivelä , L , Kurppa , K & Kaukinen , K 2022 , ' Review article : Systemic consequences of coeliac disease ' , Alimentary Pharmacology & Therapeutics , vol. 56 , pp. S64-S72 . https://doi.org/10.1111/apt.16912
Title: | Review article : Systemic consequences of coeliac disease |
Author: | Laurikka, Pilvi; Kivelä, Laura; Kurppa, Kalle; Kaukinen, Katri |
Contributor organization: | Children's Hospital HUS Children and Adolescents |
Date: | 2022-07 |
Language: | eng |
Number of pages: | 9 |
Belongs to series: | Alimentary Pharmacology & Therapeutics |
ISSN: | 0269-2813 |
DOI: | https://doi.org/10.1111/apt.16912 |
URI: | http://hdl.handle.net/10138/346506 |
Abstract: | Background The best-known symptoms of coeliac disease are related to the gastrointestinal tract, but the disease may also present with various systemic manifestations outside the intestine. Some of these consequences may remain permanent in undiagnosed individuals or if the diagnostic delay is prolonged. However, for many of the systemic manifestations, the scientific evidence remains scant and contradictory. Aims and Methods We conducted a narrative review of the most thoroughly studied and clinically relevant systemic consequences of coeliac disease, especially those that could be prevented or alleviated by early diagnosis. The review is intended particularly for physicians encountering these patients in daily clinical practice. Results The possible systemic consequences of coeliac disease extend to multiple organ systems, the best studied of which are related to skeletal, reproductive, cardiovascular and neurological systems. Furthermore, the disease is associated with an elevated risk of psychiatric comorbidities, non-Hodgkin lymphomas and intestinal adenocarcinoma. Conclusions The various systemic consequences of coeliac disease play a significant role in the overall health of patients. Early diagnosis and treatment with a gluten-free diet appear to be beneficial for most, but not all of these conditions. The possible negative metabolic and psychosocial effects of the diet should be acknowledged during follow-up. |
Subject: |
coeliac disease
complication extraintestinal gluten-free diet malignancy manifestation GLUTEN-FREE DIET BONE-MINERAL DENSITY BODY-MASS INDEX RISK-FACTORS GASTROINTESTINAL SYMPTOMS TISSUE TRANSGLUTAMINASE COGNITIVE IMPAIRMENT ARTERIAL STIFFNESS FRACTURE RISK FOLLOW-UP 3121 General medicine, internal medicine and other clinical medicine 317 Pharmacy |
Peer reviewed: | Yes |
Rights: | cc_by_nc |
Usage restriction: | openAccess |
Self-archived version: | publishedVersion |
Total number of downloads: Loading...
Files | Size | Format | View |
---|---|---|---|
Aliment_Pharmac ... ces_of_coeliac_disease.pdf | 1008.Kb |
View/ |