Review article : Systemic consequences of coeliac disease

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Laurikka , P , Kivelä , L , Kurppa , K & Kaukinen , K 2022 , ' Review article : Systemic consequences of coeliac disease ' , Alimentary Pharmacology & Therapeutics , vol. 56 , pp. S64-S72 . https://doi.org/10.1111/apt.16912

Title: Review article : Systemic consequences of coeliac disease
Author: Laurikka, Pilvi; Kivelä, Laura; Kurppa, Kalle; Kaukinen, Katri
Contributor organization: Children's Hospital
HUS Children and Adolescents
Date: 2022-07
Language: eng
Number of pages: 9
Belongs to series: Alimentary Pharmacology & Therapeutics
ISSN: 0269-2813
DOI: https://doi.org/10.1111/apt.16912
URI: http://hdl.handle.net/10138/346506
Abstract: Background The best-known symptoms of coeliac disease are related to the gastrointestinal tract, but the disease may also present with various systemic manifestations outside the intestine. Some of these consequences may remain permanent in undiagnosed individuals or if the diagnostic delay is prolonged. However, for many of the systemic manifestations, the scientific evidence remains scant and contradictory. Aims and Methods We conducted a narrative review of the most thoroughly studied and clinically relevant systemic consequences of coeliac disease, especially those that could be prevented or alleviated by early diagnosis. The review is intended particularly for physicians encountering these patients in daily clinical practice. Results The possible systemic consequences of coeliac disease extend to multiple organ systems, the best studied of which are related to skeletal, reproductive, cardiovascular and neurological systems. Furthermore, the disease is associated with an elevated risk of psychiatric comorbidities, non-Hodgkin lymphomas and intestinal adenocarcinoma. Conclusions The various systemic consequences of coeliac disease play a significant role in the overall health of patients. Early diagnosis and treatment with a gluten-free diet appear to be beneficial for most, but not all of these conditions. The possible negative metabolic and psychosocial effects of the diet should be acknowledged during follow-up.
Subject: coeliac disease
complication
extraintestinal
gluten-free diet
malignancy
manifestation
GLUTEN-FREE DIET
BONE-MINERAL DENSITY
BODY-MASS INDEX
RISK-FACTORS
GASTROINTESTINAL SYMPTOMS
TISSUE TRANSGLUTAMINASE
COGNITIVE IMPAIRMENT
ARTERIAL STIFFNESS
FRACTURE RISK
FOLLOW-UP
3121 General medicine, internal medicine and other clinical medicine
317 Pharmacy
Peer reviewed: Yes
Rights: cc_by_nc
Usage restriction: openAccess
Self-archived version: publishedVersion


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