Continuation of fibrate therapy in patients with metabolic syndrome and COVID-19 : a beneficial regime worth pursuing

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Vuorio , A , Brinck , J & Kovanen , P T 2022 , ' Continuation of fibrate therapy in patients with metabolic syndrome and COVID-19 : a beneficial regime worth pursuing ' , Annals of medicine , vol. 54 , no. 1 , pp. 1952-1955 . https://doi.org/10.1080/07853890.2022.2095667

Title: Continuation of fibrate therapy in patients with metabolic syndrome and COVID-19 : a beneficial regime worth pursuing
Author: Vuorio, Alpo; Brinck, Jonas; Kovanen, Petri T.
Contributor organization: University of Helsinki
Department of Forensic Medicine
Clinicum
Date: 2022-12-31
Language: eng
Number of pages: 4
Belongs to series: Annals of medicine
ISSN: 0785-3890
DOI: https://doi.org/10.1080/07853890.2022.2095667
URI: http://hdl.handle.net/10138/346513
Abstract: Based on separate protective mechanisms related to lipid metabolism, viral cell entry and inflammation, fibrate treatment might be advantageous among patients who have been taking fibrates before SARS-CoV-2 infection and continue taking them during the infection. Based on published data on hospitalized COVID-19 patients, we recommend that the clinicians should ask their patients with metabolic syndrome who are already taking fibrates to continue fibrate treatment during the COVID-19 illness. This recommendation applies to both outpatients and hospitalized patients. However, results from the ongoing randomized controlled trials (RCTs) using fenofibrate treatment for the prevention or treatment of COVID-19 have yet to prove that fenofibrate is clinically significant for this indication.
Subject: COVID-19
fibrates
HDL cholesterol
endothelial dysfunction
metabolic syndrome
triglycerides
FENOFIBRATE
INFLAMMATION
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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