The Cow's Milk Related Symptom Score : The 2022 Update

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Vandenplas , Y , Bajerova , K , Dupont , C , Eigenmann , P , Kuitunen , M , Meyer , R , Ribes-Koninckx , C , Salvatore , S , Shamir , R & Szajewska , H 2022 , ' The Cow's Milk Related Symptom Score : The 2022 Update ' , Nutrients , vol. 14 , no. 13 , 2682 . https://doi.org/10.3390/nu14132682

Title: The Cow's Milk Related Symptom Score : The 2022 Update
Author: Vandenplas, Yvan; Bajerova, Katerina; Dupont, Christophe; Eigenmann, Philippe; Kuitunen, Mikael; Meyer, Rosan; Ribes-Koninckx, Carmen; Salvatore, Silvia; Shamir, Raanan; Szajewska, Hania
Contributor organization: University of Helsinki
Clinicum
Children's Hospital
HUS Children and Adolescents
Date: 2022-07
Language: eng
Number of pages: 14
Belongs to series: Nutrients
ISSN: 2072-6643
DOI: https://doi.org/10.3390/nu14132682
URI: http://hdl.handle.net/10138/346514
Abstract: CoMiSS((R)) was developed 7 years ago to increase the awareness of health care professionals towards the possibility that symptoms presented by infants could be related to cow's milk. While CoMiSS was conceived mostly on theoretical concepts, data is now available from 25 clinical trials. Based on this extensive research using the tool since 2015, we aim to propose an updated CoMiSS. The evidence was reviewed, debated and discussed by 10 experts, of whom seven were part of the original group. The panel concluded that the cut-off previously proposed to indicate the likelihood that symptoms may be cow's milk related should be lowered from >= 12 to >= 10. Data in healthy infants > 6 months are missing. Since the Brussels Infant and Toddlers Stool Scale (BITSS) was recently developed for non-toilet trained children, the Bristol Stool Scale was changed to the BITSS without changing the impact of stool characteristics on CoMiSS. Overall, CoMiSS raises awareness that symptoms might be cow's milk related. New studies are needed to determine if the change in cut-off and other small adaptions improve its sensitivity and specificity. Data for CoMiSS is still needed in presumed healthy infants between 6 and 12 months old. There may also be regional differences in CoMiSS, in healthy infants as well as in those with cow's milk allergy. Finally, we emphasize that CoMiSS is an awareness tool and not a diagnostic test.
Subject: cow's milk allergy
cow's milk-related symptom score
CoMiSS
functional gastrointestinal disorder
infant feeding
INDUCED ENTEROCOLITIS SYNDROME
STOOL FORM SCALE
FOOD ALLERGY
INFANTS
RISK
POPULATION
GUIDELINES
CHILDREN
GROWTH
RECOMMENDATIONS
3143 Nutrition
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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