Heterothermy and antifungal responses in bats

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http://hdl.handle.net/10138/346536

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Whiting-Fawcett , F , Field , K , Puechmaille , S J , Blomberg , A & Lilley , T M 2021 , ' Heterothermy and antifungal responses in bats ' , Current Opinion in Microbiology , vol. 62 , pp. 61-67 . https://doi.org/10.1016/j.mib.2021.05.002

Title: Heterothermy and antifungal responses in bats
Author: Whiting-Fawcett, Flora; Field, Kenneth; Puechmaille, Sébastien J.; Blomberg, Anna; Lilley, Thomas M.
Contributor organization: Zoology
Finnish Museum of Natural History
Date: 2021-08
Language: eng
Number of pages: 7
Belongs to series: Current Opinion in Microbiology
DOI: https://doi.org/10.1016/j.mib.2021.05.002
URI: http://hdl.handle.net/10138/346536
Abstract: Hibernation, a period where bats have suppressed immunity and low body temperatures, provides the psychrophilic fungus Pseudogymnoascus destructans the opportunity to colonise bat skin, leading to severe disease in susceptible species. Innate immunity, which requires less energy and may remain more active during torpor, can control infections with local inflammation in some bat species that are resistant to infection. If infection is not controlled before emergence from hibernation, ineffective adaptive immune mechanisms are activated, including incomplete Th1, ineffective Th2, and variable Th17 responses. The Th17 and neutrophil responses, normally beneficial antifungal mechanisms, appear to be sources of immunopathology for susceptible bat species, because they are hyperactivated after return to homeothermy. Non-susceptible species show both well-balanced and suppressed immune responses both during and after hibernation.
Subject: 1181 Ecology, evolutionary biology
WHITE-NOSE SYNDROME
PSEUDOGYMNOASCUS-DESTRUCTANS
DISEASE TOLERANCE
LECTIN RECEPTORS
SYNDROME FUNGUS
HIBERNATION
COMMENSALISM
INFLAMMATION
PATHOLOGY
CELLS
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: acceptedVersion


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