Chemical Composition and Anti-Urolithiatic Activity of Extracts from Argania spinosa (L.) Skeels Press-Cake and Acacia senegal (L.) Willd

Show full item record



Permalink

http://hdl.handle.net/10138/346557

Citation

El Oumari , F E , Bousta , D , Imtara , H , Lahrichi , A , Elhabbani , R , El Mouhri , G , Al Kamaly , O , Saleh , A , Parvez , M K , Grafov , A & Houssaini , T S 2022 , ' Chemical Composition and Anti-Urolithiatic Activity of Extracts from Argania spinosa (L.) Skeels Press-Cake and Acacia senegal (L.) Willd ' , Molecules , vol. 27 , no. 13 , 3973 . https://doi.org/10.3390/molecules27133973

Title: Chemical Composition and Anti-Urolithiatic Activity of Extracts from Argania spinosa (L.) Skeels Press-Cake and Acacia senegal (L.) Willd
Author: El Oumari, Fatima Ezzahra; Bousta, Dalila; Imtara, Hamada; Lahrichi, Anissa; Elhabbani, Radouane; El Mouhri, Ghita; Al Kamaly, Omkulthom; Saleh, Asmaa; Parvez, Mohammad Khalid; Grafov, Andriy; Houssaini, Tarik Sqalli
Contributor organization: Department of Chemistry
Doctoral Programme in Drug Research
Doctoral Programme in Chemistry and Molecular Sciences
Doctoral Programme in Materials Research and Nanosciences
Date: 2022-07
Language: eng
Number of pages: 13
Belongs to series: Molecules
ISSN: 1420-3049
DOI: https://doi.org/10.3390/molecules27133973
URI: http://hdl.handle.net/10138/346557
Abstract: Ethnobotanical studies have reported the traditional medicinal uses of Acacia senegal (L.) Willd. and Argania spinosa (L.) Skeels against kidney stone formation and other chronic kidney diseases. The present work is undertaken to study the litholytic activity and the inhibiting activity of calcium oxalate crystallization by bioactive compounds identified in Argania spinosa (L.) Skeels press-cake (residue of Argan oil) and in Acacia senegal (L.) Willd. The litholytic activity was studied in vitro on cystine and uric acid stones using a porous bag and an Erlenmeyer glass. The study of the inhibiting activity of calcium oxalate crystallization, was based on temporal measurements of the optical density, registered at a 620 nm wavelength for 30 min using an ultraviolet-visible spectrophotometer. The silylation method was performed to identify phytochemicals, followed by gas chromatography coupled with mass spectrophotometry (GC/MS) analysis. The results show significant litholytic activity of Argania Spinosa press-cake hydro-ethanolic extract on uric acid and cystine stones, respectively, with dissolution rates (DR) of 86.38% and 60.42% versus 3.23% and 9.48% for the hydro-ethanolic extract of Acacia senegal exudate. Furthermore, the percentages of nucleation inhibition are 83.78% and 43.77% (p < 0.05) for Argania spinosa and Acacia senegal, respectively. The results point to the detection of 17 phytochemicals in Argania spinosa press-cake extract, the majority of which are phenolic acids and have potent anti-urolithiatic action.
Subject: litholytic activity
calcium oxalate crystallization
optical density
gas chromatograph
MEDICINAL-PLANTS
IN-VITRO
CRYSTALLIZATION
116 Chemical sciences
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


Files in this item

Total number of downloads: Loading...

Files Size Format View
molecules_27_03973_v2.pdf 3.028Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record