The relative proportion of comorbidities among rhinitis and rhinosinusitis patients and their impact on visit burden

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Nuutinen , M , Lyly , A , Virkkula , P , Hytönen , M , Saarentaus , E , Mäkitie , A , Palotie , A , Torkki , P , Haukka , J & Toppila-Salmi , S 2022 , ' The relative proportion of comorbidities among rhinitis and rhinosinusitis patients and their impact on visit burden ' , Clinical and Translational Allergy , vol. 12 , no. 7 , 12181 . https://doi.org/10.1002/clt2.12181

Title: The relative proportion of comorbidities among rhinitis and rhinosinusitis patients and their impact on visit burden
Author: Nuutinen, Mikko; Lyly, Annina; Virkkula, Paula; Hytönen, Maija; Saarentaus, Elmo; Mäkitie, Antti; Palotie, Aarno; Torkki, Paulus; Haukka, Jari; Toppila-Salmi, Sanna
Contributor organization: University of Helsinki
Medicum
Clinicum
HUS Inflammation Center
Department of Dermatology, Allergology and Venereology
HUS Head and Neck Center
Korva-, nenä- ja kurkkutautien klinikka
Genomics of Neurological and Neuropsychiatric Disorders
Department of Ophthalmology and Otorhinolaryngology
Centre of Excellence in Complex Disease Genetics
Research Programs Unit
Aarno Palotie / Principal Investigator
Institute for Molecular Medicine Finland
Helsinki Institute of Life Science HiLIFE
Department of Public Health
Jari Haukka / Principal Investigator
Department of Pathology
HUS Heart and Lung Center
Keuhkosairauksien yksikkö
Date: 2022-07
Language: eng
Number of pages: 10
Belongs to series: Clinical and Translational Allergy
ISSN: 2045-7022
DOI: https://doi.org/10.1002/clt2.12181
URI: http://hdl.handle.net/10138/346572
Abstract: Background The aim was to evaluate the relative proportion of Non-steroidal anti-inflammatory drug exacerbated respiratory disease (NERD) and other comorbidities, and their impact on the burden of outpatient visits due to allergic rhinitis (AR), non-allergic rhinitis (NAR), acute rhinosinusitis (ARS), and chronic rhinosinusitis with nasal polyps (CRSwNP) and without (CRSsNP). Methods We used hospital registry data of a random sample of 5080 rhinitis/rhinosinusitis patients diagnosed during 2005-2019. International Statistical Classification of Diseases and Related Health Problems (ICD10) diagnoses, visits, and other factors were collected from electronic health records by using information extraction and data processing methods. Cox's proportional hazards model was used for modeling the time to the next outpatient visit. Results The mean (+/- standard deviation) age of the population was 33.6 (+/- 20.7) years and 56.1% were female. The relative proportion of AR, NAR, ARS, CRSsNP and CRSwNP, were 33.5%, 27.5%, 27.2%, 20.7%, and 10.9%, respectively. The most common other comorbidities were asthma (44.4%), other chronic respiratory diseases (38.5%), musculoskeletal diseases (38.4%), and cardiovascular diseases (35.7%). Non-steroidal anti-inflammatory drug exacerbated respiratory disease existed in 3.9% of all patients, and 17.7% of the CRSwNP group. The relative proportion of subjects having 1, 2, 3 and >= 4 other diseases were 18.0%, 17.6%, 17.0%, 37.0%, respectively. All diseases except AR, ARS, and mouth breathing, were associated with a high frequency of outpatient visits. Conclusions Our results revealed a high relative proportion of NERD and other comorbidities, which affect the burden of outpatient visits and hence confirm the socioeconomic impact of upper airway diseases.
Subject: allergy
asthma
chronic rhinosinusitis
non-steroidal anti-inflammatory drug exacerbated respiratory disease
rhinitis
NONALLERGIC RHINITIS
REGULARIZATION PATHS
PREVALENCE
DISEASES
ALLERGY
EUROPE
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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