Metabolic changes associated with two endocrine abnormalities in dogs : elevated fructosamine and low thyroxine

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Ottka , C , Puurunen , J , Mueller , E , Weber , C , Klein , R & Lohi , H 2022 , ' Metabolic changes associated with two endocrine abnormalities in dogs : elevated fructosamine and low thyroxine ' , Metabolomics , vol. 18 , no. 8 , 58 . https://doi.org/10.1007/s11306-022-01917-4

Title: Metabolic changes associated with two endocrine abnormalities in dogs : elevated fructosamine and low thyroxine
Author: Ottka, Claudia; Puurunen, Jenni; Mueller, Elisabeth; Weber, Corinna; Klein, Ruth; Lohi, Hannes
Contributor organization: Veterinary Biosciences
Department of Medical and Clinical Genetics
Helsinki One Health (HOH)
Hannes Tapani Lohi / Principal Investigator
Veterinary Genetics
Biosciences
University of Helsinki
Date: 2022-07-20
Language: eng
Number of pages: 6
Belongs to series: Metabolomics
ISSN: 1573-3882
DOI: https://doi.org/10.1007/s11306-022-01917-4
URI: http://hdl.handle.net/10138/346583
Abstract: Introduction Metabolomics studies in canine endocrine abnormalities are sparse and basic information on these abnormalities must be generated. Objectives To characterize the metabolic changes associated with elevated fructosamine, reflecting poor glycemic control, and low thyroxine, a thyroid hormone controlling metabolism. Methods Leftovers of clinical serum samples; 25 controls, 79 high fructosamine, and 47 low thyroxine, were analyzed using H-1 NMR and differences were evaluated using Firth logistic regression. Results Both high fructosamine and low thyroxine were associated with changes in concentrations of multiple metabolites, including glycoprotein acetyls and lipids. Conclusion These findings suggest promising makers for further research and clinical validation.
Subject: Endocrinology
Fructosamine
Thyroxine
Dog
SERUM
RISK
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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