Modulation of sensory cortical activity by deep brain stimulation in advanced Parkinson's disease

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Korsun , O , Renvall , H , Nurminen , J , Mäkelä , J P & Pekkonen , E 2022 , ' Modulation of sensory cortical activity by deep brain stimulation in advanced Parkinson's disease ' , European Journal of Neuroscience , vol. 56 , no. 2 , pp. 3979-3990 . https://doi.org/10.1111/ejn.15692

Title: Modulation of sensory cortical activity by deep brain stimulation in advanced Parkinson's disease
Author: Korsun, Olesia; Renvall, Hanna; Nurminen, Jussi; Mäkelä, Jyrki P.; Pekkonen, Eero
Contributor organization: Clinicum
University of Helsinki
BioMag Laboratory
HUS Medical Imaging Center
Motion Laboratory
HUS Children and Adolescents
HUS Neurocenter
Neurologian yksikkö
Department of Neurosciences
Date: 2022-07
Language: eng
Number of pages: 12
Belongs to series: European Journal of Neuroscience
ISSN: 0953-816X
DOI: https://doi.org/10.1111/ejn.15692
URI: http://hdl.handle.net/10138/346627
Abstract: Despite optimal oral drug treatment, about 90% of patients with Parkinson's disease develop motor fluctuation and dyskinesia within 5-10 years from the diagnosis. Moreover, the patients show non-motor symptoms in different sensory domains. Bilateral deep brain stimulation (DBS) applied to the subthalamic nucleus is considered the most effective treatment in advanced Parkinson's disease, and it has been suggested to affect sensorimotor modulation and relate to motor improvement in patients. However, observations on the relationship between sensorimotor activity and clinical improvement have remained sparse. Here, we studied the somatosensory evoked magnetic fields in 13 right-handed patients with advanced Parkinson's disease before and 7 months after stimulator implantation. Somatosensory processing was addressed with magnetoencephalography during alternated median nerve stimulation at both wrists. The strengths and the latencies of the similar to 60-ms responses at the contralateral primary somatosensory cortices were highly variable but detectable and reliably localized in all patients. The response strengths did not differ between preoperative and postoperative DBSON measurements. The change in the response strength between preoperative and postoperative condition in the dominant left hemisphere of our right-handed patients correlated with the alleviation of their motor symptoms (p = .04). However, the result did not survive correction for multiple comparisons. Magnetoencephalography appears an effective tool to explore non-motor effects in patients with Parkinson's disease, and it may help in understanding the neurophysiological basis of DBS. However, the high interindividual variability in the somatosensory responses and poor tolerability of DBSOFF condition warrants larger patient groups and measurements also in non-medicated patients.
Subject: deep brain stimulation
magnetoencephalography
non-motor cerebral activity
Parkinson's disease
somatosensory processing
SOMATOSENSORY-EVOKED-POTENTIALS
SUBTHALAMIC NUCLEUS STIMULATION
SENSORIMOTOR INTEGRATION
TEMPORAL DISCRIMINATION
MAGNETOENCEPHALOGRAPHY
PATHOPHYSIOLOGY
CONNECTIVITY
OSCILLATIONS
ACTIVATION
LEVODOPA
3112 Neurosciences
3124 Neurology and psychiatry
Peer reviewed: Yes
Rights: cc_by_nc
Usage restriction: openAccess
Self-archived version: publishedVersion


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