Voluntary Adolescent-Onset Alcohol Drinking Fails to Influence Alcohol Consumption or Anxiety-Like Behaviour in Adulthood in Female Alcohol-Preferring Rats

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Mugantseva , E , Hyytiä , P & Latvala , A 2022 , ' Voluntary Adolescent-Onset Alcohol Drinking Fails to Influence Alcohol Consumption or Anxiety-Like Behaviour in Adulthood in Female Alcohol-Preferring Rats ' , Alcohol & Alcoholism , vol. 57 , no. 3 , 063 , pp. 396-403 . https://doi.org/10.1093/alcalc/agab063

Title: Voluntary Adolescent-Onset Alcohol Drinking Fails to Influence Alcohol Consumption or Anxiety-Like Behaviour in Adulthood in Female Alcohol-Preferring Rats
Author: Mugantseva, Ekaterina; Hyytiä, Petri; Latvala, Antti
Contributor organization: Institute for Molecular Medicine Finland
Medicum
Helsinki In Vivo Animal Imaging Platform (HAIP)
Department of Pharmacology
Institute of Criminology and Legal Policy
Faculty Common Matters (Faculty of Education)
Date: 2022-05-10
Language: eng
Number of pages: 8
Belongs to series: Alcohol & Alcoholism
ISSN: 0735-0414
DOI: https://doi.org/10.1093/alcalc/agab063
URI: http://hdl.handle.net/10138/346631
Abstract: Aims: Alcohol exposure during adolescence is associated with both increased risk for alcohol use disorders and anxiety in adulthood. Our present experiments examined this association using alcohol-preferring AA (Alko Alcohol) rats selected for high voluntary alcohol drinking. Methods: Two groups of female AA rats acquired alcohol drinking at different ages. We gave the adolescent-onset group free choice to 10% alcohol and water for seven weeks, starting on post-natal day 42 (PND 42), whereas the adult-onset group started drinking alcohol on PND 112. After the 7-week drinking, we withdrew the adolescent group from alcohol for two weeks, followed by another voluntary 7-week drinking period, started at the same age as the adult-onset group. We assessed anxiety-like behaviour repeatedly during alcohol drinking with open field and elevated plus maze tests. At the end of alcohol drinking, we also tested the rats using the light/dark box, stress-induced body temperature test and social dominance test. Results: During the first 7-week alcohol drinking, adolescent rats exhibited significantly slower acquisition of alcohol drinking and lower alcohol preference than the adult-onset group. However, when tested at the same age as the adult-onset rats, they displayed identical alcohol intake and preference. We found no alcohol-induced effects on anxiety- or stress-related behaviour in the experimental groups at any time points. Conclusions: These data show that the genetically determined phenotype of high alcohol drinking of the female alcohol-preferring AA rats is not associated with a predisposition to develop anxiety-like behaviour following voluntary alcohol exposure, even when initiated during adolescence.
Subject: USE DISORDERS
ETHANOL DRINKING
SUBSTANCE USE
ANIMAL-MODEL
EXPOSURE
AA
NEUROBIOLOGY
ALTERS
AGE
3124 Neurology and psychiatry
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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