Polycythemia is uncommon in dogs with chronic hypoxic pulmonary disease

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Holopainen , S , Laurila , H P , Lappalainen , A K , Rajamaki , M M & Viitanen , S J 2022 , ' Polycythemia is uncommon in dogs with chronic hypoxic pulmonary disease ' , Journal of Veterinary Internal Medicine , vol. 36 , no. 4 , pp. 1202-1210 . https://doi.org/10.1111/jvim.16466

Title: Polycythemia is uncommon in dogs with chronic hypoxic pulmonary disease
Author: Holopainen, Saila; Laurila, Henna P.; Lappalainen, Anu K.; Rajamaki, Minna M.; Viitanen, Sanna J.
Contributor organization: Small Animal Hospital
Department of Medical and Clinical Genetics
Departments of Faculty of Veterinary Medicine
Equine and Small Animal Medicine
Helsinki One Health (HOH)
Petbone – ortopedia, fysioterapia, kivunlievitys
Date: 2022-07
Language: eng
Number of pages: 9
Belongs to series: Journal of Veterinary Internal Medicine
ISSN: 0891-6640
DOI: https://doi.org/10.1111/jvim.16466
URI: http://hdl.handle.net/10138/346640
Abstract: Background Prolonged tissue hypoxia caused by chronic pulmonary disease is commonly regarded as an important mechanism in the development of secondary polycythemia, but little clinical data are available to support this hypothesis. Objective To study the prevalence and severity of erythrocytosis accompanying chronic hypoxic pulmonary disease in dogs. Animals Forty-seven dogs with hypoxic chronic pulmonary disease, 27 dogs with nonhypoxic chronic pulmonary disease, and 60 healthy controls. Methods Dogs with chronic pulmonary disease and chronic hypoxemia (partial pressure of arterial oxygen [PaO2] < 80 mm Hg on at least 2 arterial blood gas measurements a minimum of 1 month apart) were identified retrospectively from patient records. Association between arterial oxygen and red blood cell parameters was analyzed using Pearson's correlation coefficients and multivariable linear regression analysis. Results Red blood cell parameters measured at the end of the hypoxemia period were within the laboratory reference range in most dogs. In chronically hypoxemic dogs, hematocrit (Hct) was increased in 4/47 (8.5%; 95% confidence interval [CI], 0-17) dogs, erythrocyte count (Erytr) was increased in 12/47 (26%; 95%CI, 13-38) dogs and hemoglobin concentration (Hb) was increased in 3/47 (6.4%; 95%CI, 0-14) dogs. No marked polycythemia (Hct >= 65%) was noted in any of the dogs. Red blood cell parameters were not associated with the severity of hypoxemia (correlation to PaO2: Erytr, r = -.14; Hb, r = -.21; Hct, r = -.14; P > .05 for all). Conclusions and Clinical Importance Polycythemia is uncommon, and usually mild if present, in dogs with chronic hypoxia caused by pulmonary disease.
Subject: dog
erythrocytosis
hypoxemia
pulmonary
HIGH-ALTITUDE
SERUM ERYTHROPOIETIN
PRE-ADAPTATION
FIBROSIS
ANEMIA
INTERMITTENT
HYPOXEMIA
GROWTH
CATS
413 Veterinary science
Peer reviewed: Yes
Rights: cc_by_nc
Usage restriction: openAccess
Self-archived version: publishedVersion


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