Optimal peripheral nerve stimulation intensity for paired associative stimulation with high-frequency peripheral component in healthy subjects

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Pohjonen , M , Nyman , A-L , Kirveskari , E , Arokoski , J & Shulga , A 2022 , ' Optimal peripheral nerve stimulation intensity for paired associative stimulation with high-frequency peripheral component in healthy subjects ' , Scientific Reports , vol. 12 , no. 1 , 12466 . https://doi.org/10.1038/s41598-022-16811-1

Title: Optimal peripheral nerve stimulation intensity for paired associative stimulation with high-frequency peripheral component in healthy subjects
Author: Pohjonen, Markus; Nyman, Anna-Lena; Kirveskari, Erika; Arokoski, Jari; Shulga, Anastasia
Contributor organization: HUS Medical Imaging Center
HUS Diagnostic Center
BioMag Laboratory
Kliinisen neurofysiologian yksikkö
Department of Neurosciences
Helsinki University Hospital Area
Department of Surgery
HUS Internal Medicine and Rehabilitation
University of Helsinki
HUS Neurocenter
Date: 2022-07-21
Language: eng
Number of pages: 7
Belongs to series: Scientific Reports
ISSN: 2045-2322
DOI: https://doi.org/10.1038/s41598-022-16811-1
URI: http://hdl.handle.net/10138/346670
Abstract: Paired associative stimulation (PAS) with high-frequency peripheral nerve stimulation (PNS), called “high-PAS”, induces motor-evoked potential (MEP) potentiation in healthy subjects and improves muscle activity and independence in incomplete spinal cord injury patients. Data on optimal PNS intensity in PAS are scarce. In a high-PAS protocol, PNS intensity is defined as “minimal intensity required to produce F-responses”. We sought to further refine this definition and to investigate how PNS intensity affects PAS outcome. Two experiments were performed on 10 healthy subjects where MEP amplitude change was measured 0, 30, and 60 min after PAS. In the first experiment, the intensity required to achieve 7/10 persistence of F-responses was used to define PNS intensity level. In the second experiment, we used the intensity required to achieve 1/10 persistence (“baseline”). In addition, we applied this intensity at + 25%, − 25%, and − 50% levels. In the first experiment, PAS did not produce significant MEP potentiation. In the second experiment, PAS produced statistically significant MEP potentiation, with PNS intensity of “baseline” and “baseline − 25%” levels but not at + 25% or − 50% levels. In conclusion, for PAS utilizing high-frequency PNS, the intensity required to achieve 1/10 F-response persistence or the intensity 25% lower produces significant MEP potentiation in healthy subjects.
Description: Publisher Copyright: © 2022, The Author(s).
Subject: CORTICAL EXCITABILITY
INDUCTION
MOTOR CORTEX
PLASTICITY
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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