Long-term cognitive functioning is impaired in ICU-treated COVID-19 patients : a comprehensive controlled neuropsychological study

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http://hdl.handle.net/10138/346673

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Ollila , H , Pihlaja , R , Koskinen , S , Tuulio-Henriksson , A , Salmela , V , Tiainen , M , Hokkanen , L & Hästbacka , J 2022 , ' Long-term cognitive functioning is impaired in ICU-treated COVID-19 patients : a comprehensive controlled neuropsychological study ' , Critical Care , vol. 26 , no. 1 , 223 . https://doi.org/10.1186/s13054-022-04092-z

Title: Long-term cognitive functioning is impaired in ICU-treated COVID-19 patients : a comprehensive controlled neuropsychological study
Author: Ollila, Henriikka; Pihlaja, Riikka; Koskinen, Sanna; Tuulio-Henriksson, Annamari; Salmela, Viljami; Tiainen, Marjaana; Hokkanen, Laura; Hästbacka, Johanna
Contributor organization: Helsinki University Hospital Area
Anestesiologian yksikkö
HUS Perioperative, Intensive Care and Pain Medicine
Department of Psychology and Logopedics
HUS Neurocenter
University of Helsinki
Medicum
Faculty Common Matters (Faculty of Education)
Faculty Common Matters (Faculty of Medicine)
Perception Action Cognition
Neurologian yksikkö
Department of Neurosciences
Clinicum
Department of Diagnostics and Therapeutics
Date: 2022-12
Language: eng
Belongs to series: Critical Care
ISSN: 1364-8535
DOI: https://doi.org/10.1186/s13054-022-04092-z
URI: http://hdl.handle.net/10138/346673
Abstract: Background: Cognitive impairment has emerged as a common post-acute sequela of coronavirus disease 2019 (COVID-19). We hypothesised that cognitive impairment exists in patients after COVID-19 and that it is most severe in patients admitted to the intensive care unit (ICU). Methods: This prospective controlled cohort study of 213 participants performed at the Helsinki University Hospital and the University of Helsinki, Finland, comprised three groups of patients—ICU-treated (n = 72), ward-treated (n = 49), and home-isolated (n = 44)—with confirmed COVID-19 between March 13 and December 31, 2020, participating in a comprehensive neuropsychological evaluation six months after the acute phase. Our study included a control group with no history of COVID-19 (n = 48). Medical and demographic data were collected from electronic patient records and interviews carried out four months after the acute phase. Questionnaires filled six months after the acute phase provided information about change in cognitive functioning observed by a close informant, as well as the presence of self-reported depressive and post-traumatic symptoms. Results: The groups differed (effect size η2p = 0.065, p = 0.004) in the total cognitive score, calculated from neuropsychological measures in three domains (attention, executive functions, and memory). Both ICU-treated (p = 0.011) and ward-treated patients (p = 0.005) performed worse than home-isolated patients. Among those with more than 12 years of education, ICU-treated patients performed worse in the attention domain than ward-treated patients (p = 0.021) or non-COVID controls (p = 0.045); ICU-treated male patients, in particular, were impaired in executive functions (p = 0.037). Conclusions: ICU-treated COVID-19 patients, compared to patients with less severe acute COVID-19 or non-COVID controls, showed more severe long-term cognitive impairment. Among those with more than 12 years of education, impairment existed particularly in the domains of attention and for men, of executive functions. Trial registration number: ClinicalTrials.gov NCT04864938, retrospectively registered February 9, 2021.
Description: Publisher Copyright: © 2022, The Author(s).
Subject: Cognitive functioning
Cognitive impairment
COVID-19
Intensive care unit
Long-term outcome
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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