Clinical frailty and outcome after mechanical thrombectomy for stroke in patients aged > 80 years

Show simple item record Tiainen, Marjaana Martinez-Majander, Nicolas Virtanen, Pekka Räty, Silja Strbian, Daniel 2022-11-24T11:05:01Z 2022-11-24T11:05:01Z 2022-12
dc.identifier.citation Tiainen , M , Martinez-Majander , N , Virtanen , P , Räty , S & Strbian , D 2022 , ' Clinical frailty and outcome after mechanical thrombectomy for stroke in patients aged > 80 years ' , Journal of Stroke & Cerebrovascular Diseases , vol. 31 , no. 12 , 106816 .
dc.identifier.other PURE: 237377293
dc.identifier.other PURE UUID: 103c735e-6999-49e1-b373-d951ad9d4f2b
dc.identifier.other WOS: 000878291000012
dc.description.abstract Objectives: Data concerning the results of endovascular thrombectomy (EVT) in old patients is still limited. We aimed to investigate the outcomes in thrombectomytreated ischemic stroke patients aged > 80 years, focusing on frailty as a contributing factor. Patients and methods: We performed a single-centre retrospective cohort study with 159 consecutive patients aged > 80 years and treated with EVT for acute ischemic stroke between January 1st 2016 and December 31st 2019. Pre-admission frailty was assessed with the Clinical Frailty Scale (CFS). Patients with CFS > 5 were defined as frail. The main outcome was very poor outcome defined as mRS 46 at three months after EVT. Secondary outcomes were recanalization status, symptomatic intracerebral haemorrhage (sICH), and one-year survival. Finally, we recorded if the patient returned home within 12 months. Results: Very poor outcome was observed in 57.9% of all patients (52.4% in non-frail and 79.4% in frail patients). Rates of recanalization and sICH were comparable in frail and non-frail patients. Of all patients, 46.5% were able to live at home within 1 year after stroke. One-year survival was 59.1% (65.6% in non-frail and 35.3% in frail patients). In logistic regression analysis higher admission NIHSS, not performing thrombolysis, lack of recanalization and higher frailty status were all independently associated with very poor three-month outcome. Factors associated with one-year mortality were male gender, not performing thrombolysis, sICH, and higher frailty status. Conclusion: Almost 60% of studied patients had very poor outcome. Frailty significantly increases the likelihood of very poor outcome and death after EVT-treated stroke.(c) 2022 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license ( en
dc.format.extent 7
dc.language.iso eng
dc.relation.ispartof Journal of Stroke & Cerebrovascular Diseases
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Ischemic stroke
dc.subject Thrombectomy
dc.subject Frailty
dc.subject Elderly
dc.subject PREVALENCE
dc.subject GUIDELINES
dc.subject MORTALITY
dc.subject THERAPY
dc.subject LEVEL
dc.subject OLDER
dc.subject CARE
dc.subject 3124 Neurology and psychiatry
dc.title Clinical frailty and outcome after mechanical thrombectomy for stroke in patients aged > 80 years en
dc.type Article
dc.contributor.organization Clinicum
dc.contributor.organization Helsinki University Hospital Area
dc.contributor.organization HUS Neurocenter
dc.contributor.organization HUS Medical Imaging Center
dc.description.reviewstatus Peer reviewed
dc.relation.issn 1052-3057
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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