Auditory and cognitive deficits associated with acquired amusia after stroke : a magnetoencephalography and neuropsychological follow-up study

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Sarkamo , T , Tervaniemi , M , Soinila , S , Autti , T , Silvennoinen , H M , Laine , M , Hietanen , M & Pihko , E 2010 , ' Auditory and cognitive deficits associated with acquired amusia after stroke : a magnetoencephalography and neuropsychological follow-up study ' , PLoS One , vol. 5 , no. 11 , pp. e15157 . https://doi.org/10.1371/journal.pone.0015157

Title: Auditory and cognitive deficits associated with acquired amusia after stroke : a magnetoencephalography and neuropsychological follow-up study
Author: Sarkamo, Teppo; Tervaniemi, Mari; Soinila, Seppo; Autti, Taina; Silvennoinen, Heli M.; Laine, Matti; Hietanen, Marja; Pihko, Elina
Contributor: University of Helsinki, Behavioural Sciences
University of Helsinki, Behavioural Sciences
University of Helsinki, Neurologian yksikkö
University of Helsinki, Department of Diagnostics and Therapeutics
University of Helsinki, Department of Diagnostics and Therapeutics
University of Helsinki, Neurologian yksikkö
University of Helsinki, BioMag Laboratory
Date: 2010
Language: eng
Number of pages: 12
Belongs to series: PLoS One
ISSN: 1932-6203
URI: http://hdl.handle.net/10138/41134
Abstract: Acquired amusia is a common disorder after damage to the middle cerebral artery (MCA) territory. However, its neurocognitive mechanisms, especially the relative contribution of perceptual and cognitive factors, are still unclear. We studied cognitive and auditory processing in the amusic brain by performing neuropsychological testing as well as magnetoencephalography (MEG) measurements of frequency and duration discrimination using magnetic mismatch negativity (MMNm) recordings. Fifty-three patients with a left (n = 24) or right (n = 29) hemisphere MCA stroke (MRI verified) were investigated 1 week, 3 months, and 6 months after the stroke. Amusia was evaluated using the Montreal Battery of Evaluation of Amusia (MBEA). We found that amusia caused by right hemisphere damage (RHD), especially to temporal and frontal areas, was more severe than amusia caused by left hemisphere damage (LHD). Furthermore, the severity of amusia was found to correlate with weaker frequency MMNm responses only in amusic RHD patients. Additionally, within the RHD subgroup, the amusic patients who had damage to the auditory cortex (AC) showed worse recovery on the MBEA as well as weaker MMNm responses throughout the 6-month follow-up than the non-amusic patients or the amusic patients without AC damage. Furthermore, the amusic patients both with and without AC damage performed worse than the non-amusic patients on tests of working memory, attention, and cognitive flexibility. These findings suggest domain-general cognitive deficits to be the primary mechanism underlying amusia without AC damage whereas amusia with AC damage is associated with both auditory and cognitive deficits.
Subject: MUSIC PERCEPTION DEFICITS
MISMATCH NEGATIVITY MMN
CONGENITAL AMUSIA
SPEECH INTONATION
BRAIN RESPONSES
NEURAL-NETWORKS
PITCH
CORTEX
MEMORY
DISCRIMINATION
515 Psychology
3112 Neurosciences
312 Clinical medicine
6131 Theatre, dance, music, other performing arts
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