Capasso , C , Hirvinen , M & Cerullo , V 2013 , ' Beyond Gene Delivery: Strategies to Engineer the Surfaces of Viral Vectors ' , Biomedicines , vol. 1 , no. 1 , pp. 3-16 . https://doi.org/10.3390/biomedicines1010003
Title: | Beyond Gene Delivery: Strategies to Engineer the Surfaces of Viral Vectors |
Author: | Capasso, Cristian; Hirvinen, Mari; Cerullo, Vincenzo |
Contributor organization: | Faculty of Pharmacy Division of Biopharmaceutics and Pharmacokinetics (-2018) Division of Pharmaceutical Biosciences ImmunoViroTherapy Lab |
Date: | 2013-12-04 |
Language: | eng |
Number of pages: | 14 |
Belongs to series: | Biomedicines |
ISSN: | 2227-9059 |
DOI: | https://doi.org/10.3390/biomedicines1010003 |
URI: | http://hdl.handle.net/10138/42868 |
Abstract: | Viral vectors have been extensively studied due to their great transduction efficiency compared to non-viral vectors. These vectors have been used extensively in gene therapy, enabling the comprehension of, not only the advantages of these vectors, but also the limitations, such as the activation of the immune system after vector administration. Moreover, the need to control the target of the vector has led to the development of chemical and non-chemical modifications of the vector surface, allowing researchers to modify the tropism and biodistribution profile of the vector, leading to the production of viral vectors able to target different tissues and organs. This review describes recent non-genetic modifications of the surfaces of viral vectors to decrease immune system activation and to control tissue targeting. The developments described herein provide opportunities for applications of gene therapy to treat acquired disorders and genetic diseases and to become useful tools in regenerative medicine. |
Description: | There is an errata corrige made after the publication. |
Subject: |
318 Medical biotechnology
ADENOVIRAL VECTOR Gene Therapy MODIFICATION |
Peer reviewed: | Yes |
Usage restriction: | openAccess |
Self-archived version: | acceptedVersion |
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