Beyond Gene Delivery: Strategies to Engineer the Surfaces of Viral Vectors

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http://hdl.handle.net/10138/42868

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Capasso , C , Hirvinen , M & Cerullo , V 2013 , ' Beyond Gene Delivery: Strategies to Engineer the Surfaces of Viral Vectors ' , Biomedicines , vol. 1 , no. 1 , pp. 3-16 . https://doi.org/10.3390/biomedicines1010003

Title: Beyond Gene Delivery: Strategies to Engineer the Surfaces of Viral Vectors
Author: Capasso, Cristian; Hirvinen, Mari; Cerullo, Vincenzo
Contributor: University of Helsinki, Faculty of Pharmacy
University of Helsinki, Faculty of Pharmacy
University of Helsinki, Faculty of Pharmacy
Date: 2013-12-04
Language: eng
Number of pages: 14
Belongs to series: Biomedicines
ISSN: 2227-9059
URI: http://hdl.handle.net/10138/42868
Abstract: Viral vectors have been extensively studied due to their great transduction efficiency compared to non-viral vectors. These vectors have been used extensively in gene therapy, enabling the comprehension of, not only the advantages of these vectors, but also the limitations, such as the activation of the immune system after vector administration. Moreover, the need to control the target of the vector has led to the development of chemical and non-chemical modifications of the vector surface, allowing researchers to modify the tropism and biodistribution profile of the vector, leading to the production of viral vectors able to target different tissues and organs. This review describes recent non-genetic modifications of the surfaces of viral vectors to decrease immune system activation and to control tissue targeting. The developments described herein provide opportunities for applications of gene therapy to treat acquired disorders and genetic diseases and to become useful tools in regenerative medicine.
Subject: 318 Medical biotechnology
ADENOVIRAL VECTOR
Gene Therapy
MODIFICATION
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