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  • Alcamo, J.; Amann, M; Hettelingh, J.-P.; Holmberg, M.; Hordijk, L.; Kämäri, J.; Kauppi, L.; Kauppi, P.; Kornai, G.; Mäkelä, A. (Royal Swedish Academy of Sciences, 1987)
  • Kauppi, P.E.; Kämäri, J.; Posch, M.; Kauppi, L.; Matzner, E. (Elsevier, 1986)
  • Alcamo, J.; Kauppi, P.E.; Posch, M.; Runca, E. (IIASA, 1984)
  • Leinonen, Jussi; Moisseev, Dmitri; Leskinen, Matti; Petersen, Walter A. (AMERICAN METEOROLOGICAL SOCIETY, 2012)
    To improve the understanding of high-latitude rain microphysics and its implications for the remote sensing of rainfall by ground-based and spaceborne radars, raindrop size measurements have been analyzed that were collected over five years with a Joss–Waldvogel disdrometer located in Järvenpää, Finland. The analysis shows that the regional climate is characterized by light rain and small drop size with narrow size distributions and that the mutual relations of drop size distribution parameters differ from those reported at lower latitudes. Radar parameters computed from the distributions demonstrate that the high latitudes are a challenging target for weather radar observations, particularly those employing polarimetric and dual-frequency techniques. Nevertheless, the findings imply that polarimetric ground radars can produce reliable “ground truth” estimates for space observations and identify dual-frequency radars utilizing a W-band channel as promising tools for observing rainfall in the high-latitude climate.
  • Eronen, J. T.; Micheels, A.; Utescher, T. (EVOLUTIONARY ECOLOGY LTD, 2011)
  • Clark, Christine; Palta, Priit; Joyce, Christopher J.; Scott, Carol; Grundberg, Elin; Deloukas, Panos; Palotie, Aarno; Coffey, Alison J. (Public Library of Science, 2012)
  • Karttunen, Lauri; Koskenniemi, Kimmo; Kaplan, Ronald (Center for the Study of Language and Information, Stanford University, 1987)
  • Gritsevich, Maria; Vinnikov, Vladimir; Kohout, Tomas; Toth, Juraj; Peltoniemi, Jouni; Turchak, Leonid; Virtanen, Jenni (University of Arizona, Dept. of Geosciences, 2014)
    Abstract–In this study, we conduct a detailed analysis of the Košice meteorite fall (February28, 2010), to derive a reliable law describing the mass distribution among the recovered fragments. In total, 218 fragments of the Košice meteorite, with a total mass of 11.285 kg, were analyzed. Bimodal Weibull, bimodal Grady, and bimodal lognormal distributions are found to be the most appropriate for describing the Košice fragmentation process. Based on the assumption of bimodal lognormal, bimodal Grady, bimodal sequential, and bimodal Weibull fragmentation distributions, we suggest that, prior to further extensive fragmentation in the lower atmosphere, the Košice meteoroid was initially represented by two independent pieces with cumulative residual masses of approximately 2 and 9 kg, respectively. The smaller piece produced about 2 kg of multiple lightweight meteorite fragments with the mean around 12 g. The larger one resulted in 9 kg of meteorite fragments, recovered on the ground, including the two heaviest pieces of 2.374 kg and 2.167 kg with the mean around 140 g. Based on our investigations, we conclude that two to three larger fragments of 500–1000 g each should exist, but were either not recovered or not reported by illegal meteorite hunters.
  • Holmgren, Noel Michael Andre; Norrstrom, Niclas; Aps, Robert; Kuikka, Sakari (Public Library of Science, 2014)
  • Peltonen, Matti (SKS Finnish Literature Society, 2013)
  • Torppa, Ritva; Faulkner, Andrew; Vainio, Martti; Järvikivi, Juhani (2010)
    Two experiments investigated the perception of compound vs. phrasal stress and narrow focus in normally hearing children and children with Cochlear Implants (CI). Additionally, we investigated whether musical experience would predict children’s performance in these tasks. The results showed no difference between CI and normal-hearing (NH) children in either experiment. However, whereas we found no clear effect of age in the children’s stress detection, there was a clear age related trajectory in the ability to recognise (narrow) focus. Moreover, this trend was similar to what has been found previously for English children. Importantly, prior music experience was significantly linked to CI children’s perception of focus.
  • Cardone, Giuseppe; Nazarov, Sergey; Taskinen, Jari (ELSEVIER FRANCE, 2009)
  • Makgahlela, Mahlako; Mäntysaari, Esa; Strandén, Ismo; Koivula, Minna; Sillanpää, Mikko; Nielsen, Ulrik; Juga, Jarmo (2011)
    Current genomic prediction equations, when carried out in multiple populations with admixed structures ignore structure and assume these populations are uniform. The observed reliabilities of direct genomic breeding values (DGV) for unproven bulls in these populations so far have been low. The current study evaluated reliabilities of DGV in selection candidates using multi-trait random regression model which account for interactions between marker effects and breed of origin in the admixed Nordic Red dairy cattle. Our breed-specific model used breed proportions (BP) as random predictors and deregressed proofs of estimated breeding values (DRP) as response variables weighted by approximated reliability of DRP. Reliabilities were explored as squared correlation between DRP and DGV, weighted by the mean reliability of DRP. Estimated reliabilities were low for milk (0.32) and protein (0.32) and slightly higher (0.42) for fat. Observed reliabilities were similar to those estimated assuming homogenous structure. The Nordic Red cattle is admixed but closely related, thus, the model under investigation may have been unable to differentiate additive genetic effects by breed of origin with a medium dense marker data
  • Tirri, Kirsi; Tolppanen, Sakari Petteri; Aksela, Maija Katariina; Kuusisto, Elina (Hindawi Publishing Corporation, 2012)
    This study investigated the number and nature of gifted female and male students’ scientific, societal, and moral questions concerning science. The participants (N=658) of this study were 16-19 year-old international students from 55 countries, and two continents, Asia and Europe. They applied to participate in the Millennium Youth Camp held in 2011 in Finland. The students came from scientifically and mathematically oriented schools and they had shown an interest towards science through competitions, school success, and their own research. The students were asked to formulate questions they would like to get answers to during the camp. The nature and number of the students’ questions were analyzed with qualitative and quantitative content analysis. The results showed that the boys asked more scientific questions than the girls, and the girls asked more societal questions than the boys. The students asked less questions about morality than scientific or societal questions. The most common questions about morality were related to pollution and fresh air, environmental problems, and water protection. The results point to the need for teachers to teach socioscientific issues and discuss moral questions related to science. This should be done to increase moral sensitivity and influence the future of humankind.
  • Määttänen, Pentti (Suomalainen Tiedeakatemia, 1993)
  • Pyykkönen, Pirita; Järvikivi, Juhani (HOGREFE & HUBER PUBLISHERS, 2010)
    A visual world eye-tracking study investigated the activation and persistence of implicit causality information in spoken language comprehension. We showed that people infer the implicit causality of verbs as soon as they encounter such verbs in discourse, as is predicted by proponents of the immediate focusing account (Greene & McKoon, 1995; Koornneef & Van Berkum, 2006; Van Berkum, Koornneef, Otten, & Nieuwland, 2007). Interestingly, we observed activation of implicit causality information even before people encountered the causal conjunction. However, while implicit causality information was persistent as the discourse unfolded, it did not have a privileged role as a focusing cue immediately at the ambiguous pronoun when people were resolving its antecedent. Instead, our study indicated that implicit causality does not affect all referents to the same extent, rather it interacts with other cues in the discourse, especially when one of the referents is already prominently in focus.
  • Palviainen, Mari J; Junnikkala, Sami; Raekallio, Marja; Meri, Seppo; Vainio, Outi (BioMed Central, 2015)
    Abstract Background Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used to treat inflammatory pain in humans and animals. An overdose of an NSAID is nephrotoxic and can lead to acute kidney injury (AKI). Complement activation occurs in several types of renal disorders with proteinuria. The aim of this study was to investigate whether complement system becomes activated in kidneys after a high dose of NSAID. Kidney tissue and urine samples were collected from six sheep with ketoprofen-induced AKI and from six healthy control sheep. The localization of complement proteins in kidney tissue was carried out using immunohistochemical stainings, and excretion of C3 was tested by immunoblotting. Results The complement system was found to become activated in the kidney tissue as demonstrated by positive immunostaining for C1q, C3c, C4c, C5, C9 and factor H and by Western blotting analysis of C3 activation products in urine samples in sheep with AKI. Conclusions Our results thus suggest that the alternative complement pathway is activated, and it may contribute to the acute tubular injury seen in the kidneys of NSAID-induced AKI sheep. Inhibition of complement activation may serve as potential therapeutic target for intervention in drug-induced AKI.
  • Kovalchuk, Andriy; Raffaello, Tommaso; Jaber, Emad; Keriö, Susanna; Ghimire, Rajendra; Lorenz, W W; Dean, Jeffrey F; Holopainen, Jarmo K; Asiegbu, Fred O (BioMed Central, 2015)
    Abstract Background During their lifetime, conifer trees are exposed to numerous herbivorous insects. To protect themselves against pests, trees have developed a broad repertoire of protective mechanisms. Many of the plant’s defence reactions are activated upon an insect attack, and the underlying regulatory mechanisms are not entirely understood yet, in particular in conifer trees. Here, we present the results of our studies on the transcriptional response and the volatile compounds production of Scots pine (Pinus sylvestris) upon the large pine weevil (Hylobius abietis) feeding. Results Transcriptional response of Scots pine to the weevil attack was investigated using a novel customised 36.4 K Pinus taeda microarray. The weevil feeding caused large-scale changes in the pine transcriptome. In total, 774 genes were significantly up-regulated more than 4-fold (p ≤ 0.05), whereas 64 genes were significantly down-regulated more than 4-fold. Among the up-regulated genes, we could identify genes involved in signal perception, signalling pathways, transcriptional regulation, plant hormone homeostasis, secondary metabolism and defence responses. The weevil feeding on stem bark of pine significantly increased the total emission of volatile organic compounds from the undamaged stem bark area. The emission levels of monoterpenes and sesquiterpenes were also increased. Interestingly, we could not observe any correlation between the increased production of the terpenoid compounds and expression levels of the terpene synthase-encoding genes. Conclusions The obtained data provide an important insight into the transcriptional response of conifer trees to insect herbivory and illustrate the massive changes in the host transcriptome upon insect attacks. Moreover, many of the induced pathways are common between conifers and angiosperms. The presented results are the first ones obtained by the use of a microarray platform with an extended coverage of pine transcriptome (36.4 K cDNA elements). The platform will further facilitate the identification of resistance markers with the direct relevance for conifer tree breeding.
  • Hulden, Lena; Hulden, Larry (BIOMED CENTRAL LTD., 2011)
  • Chong, Sun-Li; Derba-Maceluch, Marta; Koutaniemi, Sanna; Gómez, Leonardo D; McQueen-Mason, Simon J; Tenkanen, Maija; Mellerowicz, Ewa J (BioMed Central, 2015)
    Abstract Background Expressing microbial polysaccharide-modifying enzymes in plants is an attractive approach to custom tailor plant lignocellulose and to study the importance of wall structures to plant development. Expression of α-glucuronidases in plants to modify the structures of glucuronoxylans has not been yet attempted. Glycoside hydrolase (GH) family 115 α-glucuronidases cleave the internal α-D-(4-O-methyl)glucopyranosyluronic acid ((Me)GlcA) from xylans or xylooligosaccharides. In this work, a GH115 α-glucuronidase from Schizophyllum commune, ScAGU115, was expressed in Arabidopsis thaliana and targeted to apoplast. The transgene effects on native xylans’ structures, plant development, and lignocellulose saccharification were evaluated and compared to those of knocked out glucuronyltransferases AtGUX1 and AtGUX2. Results The ScAGU115 extracted from cell walls of Arabidopsis was active on the internally substituted aldopentaouronic acid (XUXX). The transgenic plants did not show any change in growth or in lignocellulose saccharification. The cell wall (Me)GlcA and other non-cellulosic sugars, as well as the lignin content, remained unchanged. In contrast, the gux1gux2 double mutant showed a 70% decrease in (Me)GlcA to xylose molar ratio, and, interestingly, a 60% increase in the xylose content. Whereas ScAGU115-expressing plants exhibited a decreased signal in native secondary walls from the monoclonal antibody UX1 that recognizes (Me)GlcA on non-acetylated xylan, the signal was not affected after wall deacetylation. In contrast, gux1gux2 mutant was lacking UX1 signals in both native and deacetylated cell walls. This indicates that acetyl substitution on the xylopyranosyl residue carrying (Me)GlcA or on the neighboring xylopyranosyl residues may restrict post-synthetic modification of xylans by ScAGU115 in planta. Conclusions Active GH115 α-glucuronidase has been produced for the first time in plants. The cell wall–targeted ScAGU115 was shown to affect those glucuronate substitutions of xylan, which are accessible to UX1 antibody and constitute a small fraction in Arabidopsis, whereas majority of (Me)GlcA substitutions were resistant, most likely due to the shielding by acetyl groups. Plants expressing ScAGU115 did not show any defects under laboratory conditions indicating that the UX1 epitope of xylan is not essential under these conditions. Moreover the removal of the UX1 xylan epitope does not affect lignocellulose saccharification.