Browsing by Author "Aaltonen Lauri A"

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  • Alhopuro Pia; Karhu Auli; Winqvist Robert; Waltering Kati; Visakorpi Tapio; Aaltonen Lauri A (2008)
    BACKGROUND: MYH11 (also known as SMMHC) encodes the smooth-muscle myosin heavy chain, which has a key role in smooth muscle contraction. Inversion at the MYH11 locus is one of the most frequent chromosomal aberrations found in acute myeloid leukemia. We have previously shown that MYH11 mutations occur in human colorectal cancer, and may also be associated with Peutz-Jeghers syndrome. The mutations ... [More]