Artikkelit: Recent submissions

Now showing items 1-20 of 53731
  • Auvinen, P.; Vehviläinen, J.; Marjonen, H.; Modhukur, V.; Sokka, J.; Wallén, E.; Rämö, Karita; Ahola, L.; Salumets, Andres; Otonkoski, Timo; Skottman, Heli; Ollikainen, Miina; Trokovic, Ras; Kahila, Hanna; Kaminen-Ahola, Nina (2022)
  • Lapatto, Helena A. K.; Kuusela, Minna; Heikkinen, Aino; Muniandy, Maheswary; van der Kolk, Birgitta W.; Gopalakrishnan, Swetha; Pöllänen, Noora; Sandvik, Martin; Schmidt, Mark S.; Heinonen, Sini; Saari, Sina; Kuula, Juho; Hakkarainen, Antti; Tampio, Janne; Saarinen, Tuure; Taskinen, Marja-Riitta; Lundbom, Nina; Groop, Per-Henrik; Tiirola, Marja; Katajisto, Pekka; Lehtonen, Marko; Brenner, Charles; Kaprio, Jaakko; Pekkala, Satu; Ollikainen, Miina; Pietiläinen, Kirsi H.; Pirinen, Eija (2023)
    Nicotinamide adenine dinucleotide (NAD(+)) precursor nicotinamide riboside (NR) has emerged as a promising compound to improve obesity-associated mitochondrial dysfunction and metabolic syndrome in mice. However, most short-term clinical trials conducted so far have not reported positive outcomes. Therefore, we aimed to determine whether long-term NR supplementation boosts mitochondrial biogenesis and metabolic health in humans. Twenty body mass index (BMI)- discordant monozygotic twin pairs were supplemented with an escalating dose of NR (250 to 1000 mg/day) for 5 months. NR improved systemic NAD(+) metabolism, muscle mitochondrial number, myoblast differentiation, and gut microbiota composition in both cotwins. NR also showed a capacity to modulate epigenetic control of gene expression in muscle and adipose tissue in both cotwins. However, NR did not ameliorate adiposity or metabolic health. Overall, our results suggest that NR acts as a potent modifier of NAD(+) metabolism, muscle mitochondrial biogenesis and stem cell function, gut microbiota, and DNA methylation in humans irrespective of BMI.
  • Paavilainen, Aleksi (2022)
    Kirjoitus on vastine artikkelini ”Sosialisaatio ja varhaiskasvatus kapitaloseenin aikakaudella – Ekososiaalisen kasvatusteorian ekofeministinen kritiikki” (Paavilainen 2022) saamiin vastineisiin (Pulkki, Foster & Keto 2022; Saari, Kallio & Varpanen 2022). Vastaan kritiikkeihin liittyen artikkelini ekososiaalisen kasvatusteorian rajaukseen, lähestymiseni ihmiskeskeisyyteen sekä antamiini kuviin itsekasvatuksesta ja leikistä. Summaan (eko)feminististen teoretisointien voivan tarjota vielä enemmän virikettä kasvatusta ja ympäristökysymyksiä käsittelevään tutkimukseen kuin mitä ekososiaalisen kasvatuksen tutkimusartikkeleista saa irti.
  • Jalava, Maina P.; Savontaus, Mikko; Ahvenvaara, Tuomas; Laakso, Teemu; Virtanen, Marko; Niemelä, Matti; Tauriainen, Tuomas; Maaranen, Pasi; Husso, Annastiina; Kinnunen, Eve; Dahlbacka, Sebastian; Jaakkola, Jussi; Rosato, Stefano; D'Errigo, Paola; Laine, Mika; Mäkikallio, Timo; Raivio, Peter; Eskola, Markku; Valtola, Antti; Juvonen, Tatu; Biancari, Fausto; Airaksinen, Juhani; Anttila, Vesa (2022)
  • Ramo, O. Tapani; Andersen, Tom; Whitehouse, Martin J. (2022)
    The Permo-Carboniferous Oslo Rift is a narrow, aborted continental rift with comparatively little extension but voluminous magmatism, developed at a Proterozoic lithospheric discontinuity. On the southern flank of the onshore part of the rift, the multiple intrusive phase Larvik plutonic complex (LPC) encompasses almost the width of the rift with a conspicuous over- to undersaturated assemblage of monzonite (larvikite, tonsbergite) and nepheline syenite (lardalite, foyaite). We present new single-crystal U-Pb-, Lu-Hf-, and O-in-zircon isotope data for the intrusive centers of the complex. U-Pb ages of slightly over- to undersaturated monzonites show a shift in igneous activity from 299 Ma on the eastern edge of the complex to 289 Ma in the west. The western part of the complex is built of two consanguineous magmatic systems with a northward shift in the locus of magmatism, from 296 to 289 Ma (undersaturated monzonite) and 296 to similar to 288 Ma (nepheline syenite). Moreover, an early oversaturated monzonite was emplaced in the eastern part of the complex at similar to 302 Ma. The Hf and O isotope composition of the monzonites and nepheline syenites shows little variation with zircon epsilon(Hf) (295 Ma) values of +5.5 to +8 and delta(18)Omicron values of +4.79 parts per thousand to +5.49 parts per thousand. No change in isotope values is observed with varying alkalinity and the Hf and O isotope compositions are interpreted as mantle source values. The source of the precursors of the monzonitic and nepheline syenitic magmas was probably a mildly depleted, sublithospheric peridotite in the lithosphere-asthenosphere boundary zone (at 3-4 GPa). Rhyolite-MELTS modeling implies polybaric fractionation of weakly alkaline basaltic melts from the source having led to an oversaturated/saturated liquid line of descent at similar to 0.5 GPa and an undersaturated one at similar to 1 GPa. Magmatism had an imperative role in the evolution of the rift by localizing strain and weakening the lithosphere along the discontinuity. A fractionating crustal melt column was tapped at varying depths in the course of advancing rupturing with no significant mixing of the over- and undersaturated melts, and magma batches were emplaced as sequential nested plutons in response to differential opening of the rift. Among continental saturated-undersaturated alkaline complexes, the LPC may be unique in the emplacement of successive magma batches across a continental rift in the direction of opening, tapping of increasingly deeper parts of the melt column with advancing rifting, and intrusion of two contemporaneous, contrasting magmatic lineages at the end of igneous activity. The marked lithospheric step at the rift locus in the Precambrian basement of southeastern Norway was probably the driving force for the inception and evolution of the Larvik magmatic system.
  • Nikolaeva, Olga (2021)
    This article explores the creative practice of an independent Russian theatre collective, Soso Daughters. The collective was founded in Moscow by theatre director and playwright Zhenya Berkovich in 2018 and recently premiered their fourth production. The subjects of the productions the collective performs often delve into girls' and women's lives and traumatic experiences that are constantly undermined, dismissed or ignored. Driven by the feminist ethic of care, this article aims to situate Soso Daughters' creative work in the context of scan-aesthetic across the Nordic and Baltic regions, and to turn scholars and spectators' attention to the issue of an independent theatre practice in Russia. The article is based on interviews with the collective's director and scenographer as well as first-hand observations of their productions. The article further explores the possibility of representation of trauma and traumatic experience in The Rhyme, the collective's first production, grounding the analysis in that the holistic approach to scenography.
  • Lorenzon, Marta; Wallis, Caroline (2023)
    This contribution aims to use social history and social theory to investigate political power and compliance with authority in ancient Western Asia, through the case study of Neo-Assyrian imperial building projects. Our first aim is to discuss the realities of construction work in the Neo-Assyrian Empire, focusing on the building process both through literary sources and archaeological data. Our second goal is to understand the role played by these building sites in the strengthening of local and supra-local political orders, in the consolidation of social group boundaries, and in the construction of political subjectivities of the ancient social actors involved. Our reflection sheds light on the new interpretative possibilities – and challenges – that integrating social theories, archaeological work, and language technology may create.
  • Sousa-Pinto, Bernardo; Anto, Aram; Berger, Markus; Dramburg, Stephanie; Pfaar, Oliver; Klimek, Ludger; Jutel, Marek; Czarlewski, Wienczyslawa; Bedbrook, Anna; Valiulis, Arunas; Agache, Ioana; Amaral, Rita; Ansotegui, Ignacio J.; Bastl, Katharina; Berger, Uwe; Bergmann, Karl C.; Bosnic-Anticevich, Sinthia; Braido, Fulvio; Brussino, Luisa; Cardona, Victoria; Casale, Thomas; Canonica, G. Walter; Cecchi, Lorenzo; Charpin, Denis; Chivato, Tomas; Chu, Derek K.; Cingi, Cemal; Costa, Elisio M.; Cruz, Alvaro A.; Devillier, Philippe; Durham, Stephen R.; Ebisawa, Motohiro; Fiocchi, Alessandro; Fokkens, Wytske J.; Gemicioglu, Bilun; Gotua, Maia; Guzman, Maria-Antonieta; Haahtela, Tari; Carlos Ivancevich, Juan; Kuna, Piotr; Kaidashev, Igor; Khaitov, Musa; Kvedariene, Violeta; Larenas-Linnemann, Desiree E.; Lipworth, Brian; Laune, Daniel; Matricardi, Paolo M.; Morais-Almeida, Mario; Mullol, Joaquim; Naclerio, Robert; Neffen, Hugo; Nekam, Kristoff; Niedoszytko, Marek; Okamoto, Yoshitaka; Papadopoulos, Nikolaos G.; Park, Hae-Sim; Passalacqua, Giovanni; Patella, Vincenzo; Pelosi, Simone; Pham-Thi, Nhan; Popov, Ted A.; Regateiro, Frederico S.; Reitsma, Sietze; Rodriguez-Gonzales, Monica; Rosario, Nelson; Rouadi, Philip W.; Samolinski, Boleslaw; Sa-Sousa, Ana; Sastre, Joaquin; Sheikh, Aziz; Ulrik, Charlotte Suppli; Taborda-Barata, Luis; Todo-Bom, Ana; Tomazic, Peter Valentin; Toppila-Salmi, Sanna; Tripodi, Salvatore; Tsiligianni, Ioanna; Valovirta, Erkka; Ventura, Maria Teresa; Valero, Antonio A.; Vieira, Rafael Jose; Wallace, Dana; Waserman, Susan; Williams, Sian; Yorgancioglu, Arzu; Zhang, Luo; Zidarn, Mihaela; Zuberbier, Jaron; Olze, Heidi; Anto, Josep M.; Zuberbier, Torsten; Fonseca, Joao A.; Bousquet, Jean (2022)
    Digital health is an umbrella term which encompasses eHealth and benefits from areas such as advanced computer sciences. eHealth includes mHealth apps, which offer the potential to redesign aspects of healthcare delivery. The capacity of apps to collect large amounts of longitudinal, real-time, real-world data enables the progression of biomedical knowledge. Apps for rhinitis and rhinosinusitis were searched for in the Google Play and Apple App stores, via an automatic market research tool recently developed using JavaScript. Over 1500 apps for allergic rhinitis and rhinosinusitis were identified, some dealing with multimorbidity. However, only six apps for rhinitis (AirRater, AllergyMonitor, AllerSearch, Husteblume, MASK-air and Pollen App) and one for rhinosinusitis (Galenus Health) have so far published results in the scientific literature. These apps were reviewed for their validation, discovery of novel allergy phenotypes, optimisation of identifying the pollen season, novel approaches in diagnosis and management (pharmacotherapy and allergen immunotherapy) as well as adherence to treatment. Published evidence demonstrates the potential of mobile health apps to advance in the characterisation, diagnosis and management of rhinitis and rhinosinusitis patients.
  • Pakkasjarvi, Niklas; Mönttinen, Tiia; Hokkinen, Lasse; Mäkelä, Eija; Taskinen, Seppo (2022)
    Background: Retrovesical cysts present with varying etiologies. We initiated this study to provide insights into retrovesical cysts in boys through a case series and systematic literature review and to aid in treatment alternatives. Materials and methods: Case series of seven patients from the in-hospital register with a systematic literature review on retrovesical cysts in children. Results: We identified seven patients from the in-hospital register during 2005-2020 and eighty-two patients from the literature review. The literature review showed that children's retrovesical cysts are mainly asymptomatic before puberty. Those detected earlier in childhood present mostly with renal abnormalities. In our series, retrovesical cysts derived from three distinct etiologies with different treatment modalities. Asymptomatic cysts do not need excision and are to be followed up through puberty, but in the case of an ectopic ureter, nephroureterectomy is optional. Symptomatic retrovesical cysts may demand surgical excision. Ultrasonography is usually sufficient for diagnosis, but MRI provides better anatomical delineation and aids in surgical planning. Conclusions: Retrovesical cysts in boys are benign conditions associated with abnormal development of the ureter and kidney. Ultrasonography is sufficient for diagnosis, with MRI giving further detail for surgical planning. Treatment consists of cyst excision, heminephrectomy/nephrectomy, transurethral canalization, or excision of prostatic utricle, depending on etiology. Asymptomatic cases are to be followed up through puberty, but in cases of an ectopic ureter, nephroureterectomy is preferred.
  • Lonnqvist, Jan-Erik (2022)
    IntroductionI investigated the authorship gender gap in research on political psychology. MethodsThe material comprises 1,166 articles published in the field's flagship journal Political Psychology between 1997 and 2021. These were rated for author gender, methodology, purpose, and topic. ResultsWomen were underrepresented as authors (37.1% women), single authors (33.5% women), and lead authors (35.1% women). There were disproportionately many women lead authors in papers employing interviews or qualitative methodology, and in research with an applied purpose (these were all less cited). In contrast, men were overrepresented as authors of papers employing quantitative methods. Regarding topics, women were overrepresented as authors on Gender, Identity, Culture and Language, and Religion, and men were overrepresented as authors on Neuroscience and Evolutionary Psychology. DiscussionThe (denigrated) methods, purposes, and topics of women doing research on politics correspond to the (denigrated) "feminine style" of women doing politics grounding knowledge in the concrete, lived reality of others; listening and giving voice to marginalized groups' subjective experiences; and yielding power to get things done for others.
  • Jouhi, Lauri; Sikiö, Jenna; Suomalainen, Anni; Mroueh, Rayan; Mäkitie, Antti; Meurman, Jukka H. (2022)
    BackgroundHuman papilloma virus is associated with oral and oropharyngeal cancer. Our aim was to examine oral health in patients with oropharyngeal (OPSCC) and oral tongue cancer (OTSCC), expecting better oral health among OPSCC patients.Material and methodsFifty-five OPSCC patients with known HPV status and 59 OTSCC patients were randomly selected from a list of consecutive patients of the Helsinki University Hospital, Finland. Oral health was assessed from panoramic jaw radiographs. Total Dental Index (TDI) summarizing the dental health status was calculated and Finnish population study data were used for comparison. Descriptive statistics were used for analyses.ResultsPatients with HPV-positive OPSCC had higher periapical lesion index compared with HPV-negative OPSCC patients or with OTSCC patients. Residual roots were more common among OPSCC patients compared with OTSCC patients, because of their higher occurrence among HPV-negative OPSCC patients compared with OTSCC patients. Similarly, modified TDI score was significantly higher among OPSCC patients than among OTSCC patients, because of higher TDI score among HPV-negative OPSCC patients compared with OTSCC patients. OPSCC patients more often used a removable prosthesis than OTSCC patients. Dental health of the cancer patients was poorer when compared with the population data.ConclusionsOur study hypothesis was only partly confirmed. Periapical lesions were more prevalent among HPV-positive OPSCC patients, compared with the other groups. The number of residual roots was higher among HPV-negative subgroup. Thus, OPSCC patients had worse oral health parameters than OTSCC patients.
  • Ranu, Natasha; Laitila, Jenni; Dugdale, Hannah F.; Mariano, Jennifer; Kolb, Justin S.; Wallgren-Pettersson, Carina; Witting, Nanna; Vissing, John; Vilchez, Juan Jesus; Fiorillo, Chiara; Zanoteli, Edmar; Auranen, Mari; Jokela, Manu; Tasca, Giorgio; Claeys, Kristl G.; Voermans, Nicol C.; Palmio, Johanna; Huovinen, Sanna; Moggio, Maurizio; Beck, Thomas Nyegaard; Kontrogianni-Konstantopoulos, Aikaterini; Granzier, Henk; Ochala, Julien (2022)
    Nemaline myopathy (NM) is one of the most common non-dystrophic genetic muscle disorders. NM is often associated with mutations in the NEB gene. Even though the exact NEB-NM pathophysiological mechanisms remain unclear, histological analyses of patients' muscle biopsies often reveal unexplained accumulation of glycogen and abnormally shaped mitochondria. Hence, the aim of the present study was to define the exact molecular and cellular cascade of events that would lead to potential changes in muscle energetics in NEB-NM. For that, we applied a wide range of biophysical and cell biology assays on skeletal muscle fibres from NM patients as well as untargeted proteomics analyses on isolated myofibres from a muscle-specific nebulin-deficient mouse model. Unexpectedly, we found that the myosin stabilizing conformational state, known as super-relaxed state, was significantly impaired, inducing an increase in the energy (ATP) consumption of resting muscle fibres from NEB-NM patients when compared with controls or with other forms of genetic/rare, acquired NM. This destabilization of the myosin super-relaxed state had dynamic consequences as we observed a remodeling of the metabolic proteome in muscle fibres from nebulin-deficient mice. Altogether, our findings explain some of the hitherto obscure hallmarks of NM, including the appearance of abnormal energy proteins and suggest potential beneficial effects of drugs targeting myosin activity/conformations for NEB-NM.
  • Montazeri Moghadam, Saeed; Nevalainen, Päivi; Stevenson, Nathan J.; Vanhatalo, Sampsa (2022)
    Objective To develop and validate an automated method for bedside monitoring of sleep state fluctuations in neonatal intensive care units. Methods A deep learning-based algorithm was designed and trained using 53 EEG recordings from a long-term (a)EEG monitoring in 30 near-term neonates. The results were validated using an external dataset from 30 polysomnography recordings. In addition to training and validating a single EEG channel quiet sleep, we constructed Sleep State Trend (SST), a bedside-ready means for visualising classifier outputs. Results The accuracy of quiet sleep detection in the training data was 90%, and the accuracy was comparable (85-86 %) in all bipolar derivations available from the 4-electrode recordings. The algorithm generalised well to an external dataset, showing 81% overall accuracy despite different signal derivations. SST allowed an intuitive, clear visualisation of the classifier output. Conclusions Fluctuations in sleep states can be detected at high fidelity from a single EEG channel, and the results can be visualised as a transparent and intuitive trend in the bedside monitors. Significance The Sleep State Trend (SST) may provide caregivers a real-time view of sleep state fluctuations and its cyclicity.
  • Hongisto, Mari; Lassus, Johan; Tarvasmäki, Tuukka; Sans-Rosello, Jordi; Tolppanen, Heli; Kataja, Anu; Jäntti, Toni; Sabell, Tuija; Banaszewski, Marek; Silva-Cardoso, Jose; Parissis, John; Jurkko, Raija; Spinar, Jindrich; Castren, Maaret; Mebazaa, Alexandre; Masip, Josep; Harjola, Veli Pekka (2022)
    Aims Soluble urokinase-type plasminogen activator receptor (suPAR) is a biomarker reflecting the level of immune activation. It has been shown to have prognostic value in acute coronary syndrome and heart failure as well as in critical illness. Considering the complex pathophysiology of cardiogenic shock (CS), we hypothesized suPAR might have prognostic properties in CS as well. The aim of this study was to assess the kinetics and prognostic utility of suPAR in CS. Methods and results SuPAR levels were determined in serial plasma samples (0-96 h) from 161 CS patients in the prospective, observational, multicentre CardShock study. Kinetics of suPAR, its association with 90-day mortality, and additional value in risk-stratification were investigated. The median suPAR-level at baseline was 4.4 [interquartile range (IQR) 3.2-6.6)] ng/mL. SuPAR levels above median were associated with underlying comorbidities, biomarkers reflecting renal and cardiac dysfunction, and higher 90-day mortality (49% vs. 31%; P = 0.02). Serial measurements showed that survivors had significantly lower suPAR levels at all time points compared with nonsurvivors. For risk stratification, suPAR at 12 h (suPAR(12h)) with a cut-off of 4.4 ng/mL was strongly associated with mortality independently of established risk factors in CS: OR 5.6 (95% CI 2.0-15.5); P = 0.001) for death by 90 days. Adding suPAR(12h) > 4.4 ng/mL to the CardShock risk score improved discrimination identifying high-risk patients originally categorized in the intermediate-risk category. Conclusion SuPAR associates with mortality and improves risk stratification independently of other previously known risk factors in CS patients.
  • Hu, Jiancheng; Song, Zhibin; Zhou, Jiacheng; Soininen, Janne; Tan, Lu; Cai, Qinghua; Tang, Tao (2022)
    Comparing spatio-temporal patterns between planktonic and benthic algae is helpful for understanding their associations and differences. However, such studies are still rare especially in large rivers. We used a dataset collected in the upper reach of the Jinsha River in different seasons to explore biodiversity and assembly processes of planktonic and benthic diatom assemblages. We found that planktonic and benthic diatoms presented different seasonal variation in species richness and community compositions. We also found evidence that planktonic and benthic diatoms were coupled in the summer. Planktonic diatom assemblages were mainly affected by spatial processes via directional spatial dispersal, especially in the summer. By comparison, benthic diatom assemblages were more affected by environmental processes. Our findings suggest that mass effect and species sorting paradigms explain the assembly processes of planktonic and benthic diatom assemblages, respectively, but the explanatory powers of these two paradigms vary seasonally. To effectively monitor and assess ecological conditions of large rivers, we recommend using benthic algae as a biotic indicator group as they had stronger correlations with environmental factors.
  • Vainio, Lari (2021)
    Segmental properties of speech can convey sound symbolic meaning. This study presents two novel sound meaning mappings using a choice reaction time paradigm in which participants have to select quickly one of the two vocal response alternatives based on predefined categories of perceptual magnitude. The first study showed that the short distance between perceived objects facilitates the initiation of the vowel [i] production, while long distance facilitates the production of [u] and [?]. Correspondingly, in the second study, vocal responses produced with [i] and [e] were initiated faster when the stimuli required short vocalizations, while responses produced with [u], [?] and [y] were faster when the stimuli required long vocalizations. Hence, similar sound-meaning mappings were observed concerning concepts of spatial and temporal length. This suggests that different sound-magnitude effects can be generalized to the common processing of conceptual magnitude. A conceptual magnitude seems to be implicitly and systematically associated with an articulatory response of a specific vowel. The study also suggests that in addition to the vowel openness and backness, the vowel roundness can also associate particular vowels with large magnitudes.
  • Mökkönen, Teemu Olavi; Nordqvist, Kerkko (Suomen muinaismuistoyhdistys, 2022)
    Iskos
  • Pimenoff, Ville N.; Houldcroft, Charlotte J. (2021)
    Analysis of viral DNA from human remains suggests that the transatlantic slave trade may have introduced new pathogens that contributed to the devastating disease outbreaks in colonial Mexico.