Iranian J Publ Health, Vol. 42, No. 9, Sep 2013, pp.929-940 Review Article 929 Available at: http://ijph.tums.ac.ir Oral Health of Drug Abusers: A Review of Health Effects and Care Hajar SHEKARCHIZADEH 1,2, *Mohammad R. KHAMI 2,3, Simin Z. MOHEBBI 1,2, Hamed EKHTIARI 4,5, Jorma I. VIRTANEN 6,7 1. Research Center for Caries Prevention, Community Oral Health Department, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran 2. Dept. of Oral Public Health, University of Helsinki, Helsinki, Finland 3. Dental Research Center, Community Oral Health Department, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran 4. Translational Neuroscience Program, Institute for Cognitive Science Studies, Iran 5. Neurocognitive Laboratory, Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran 6. Dept. of Community Dentistry, University of Oulu, Oulu, Finland 7. Dept. of Public Health, University of Helsinki, Helsinki, Finland *Corresponding Author: Email: mkhami@tums.ac.ir (Received 22 Mar 2013; accepted 10 July 2013) Introduction Drug abuse, one of the world’s most devastating health problems (1), may also be considered a prevalent problem, because estimations show that, for example, in 2009 between 149 and 272 million 15- to 64-year-olds around the world reported us- ing illegal drugs at least once during one year (2). Among them, reports are that 11 to 21 million were injecting drug users, mainly from China, the Abstract Oral health problems, among the most prevalent comorbidities related to addiction, require more attention by both clinicians and policy-makers. Our aims were to review oral complications associated with drugs, oral health care in addiction rehabilitation, health services available, and barriers against oral health promotion among addicts. Drug abuse is associated with serious oral health problems including generalized dental caries, periodontal diseases, mucosal dysplasia, xerostomia, bruxism, tooth wear, and tooth loss. Oral health care has positive effects in recovery from drug abuse: patients’ need for pain control, destigmatization, and HIV transmission. Health care systems worldwide deliver services for addicts, but most lack oral health care programs. Barriers against oral health promotion among addicts include difficulty in accessing addicts as a target population, lack of appropriate settings and of valid assessment proto- cols for conducting oral health studies, and poor collaboration between dental and general health care sectors serving addicts. These interfere with an accurate picture of the situation. Moreover, lack of appropriate policies to improve access to dental services, lack of comprehensive knowledge of and interest among dental professionals in treating ad- dicts, and low demand for non-emergency dental care affect provision of effective interventions. Management of drug addiction as a multi-organ disease requires a multidisciplinary approach. Health care programs usually lack oral health care elements. Published evidence on oral complications related to addiction emphasizes that regardless of these barri- ers, oral health care at various levels including education, prevention, and treatment should be integrated into general care services for addicts. Keywords: Oral heath, Oral diseases, Illicit drugs, Substance-related disorders Shekarchizadeh et al.: Oral Health of Drug Abusers… Available at: http://ijph.tums.ac.ir 930 USA, and Russia (3). In Iran, based on a report from 2002, drug abuse has increased at a growth rate three times as great as population growth rate, and the annual rise in incidence of injecting drug abuse has been estimated to be 33% (4). Drug abuse results in several direct consequences including multiple physical and mental problems such as cardiac crisis, respiratory depression, liver cirrhosis, nephropathy, infectious diseases such as hepatitis, AIDS, and tuberculosis, injury-associ- ated disability, mental disorders such as depres- sion, and oral health problems (5-6). These prob- lems are partly the result of neglected self-care—a common behavior among addicts (7). Addicts usually ignore their health problems and seek health care only at advanced stages of disease with severe symptoms; this may complicate the treat- ment procedure in various ways (8-9). In this re- gard, these patients may give little priority to their own oral health by seeking only emergency treat- ment during the period of drug abuse (8, 10,11). In addition to direct consequences for addicts themselves, drug abuse has various indirect conse- quences for their circle of acquaintances and the whole society, such as reducing working time, rais- ing health care costs, violence, crime, and the bur- den of diseases (1). In Disability-Adjusted Life Years (DALYs), about 0.8%, and 0.4% of global deaths in 2000 resulted from drug abuse (12). This problem has a median relative risk of two for mortality and its annual cost exceeds 200 billion US dollars (13). According to a national survey of disease burden in Iran, illegal drug addiction and its AIDS- and accident-related consequences caused more than 800,000 DALYs in 2003. This survey ranked addiction as the fourth most im- portant health problem in the country (14). Among other indirect consequences, drug abuse is associated with increased risk of social problems such as crime in the form of drug trafficking, or theft and prostitution by drug users in order to finance their addiction. Health problems of drug abusers indirectly have negative effects on society via increasing health care costs, needle-sharing behavior, prostitution, AIDS, and other infectious diseases which result in additional health dangers for society (15). Addiction and oral health Oral health problems are among the most preva- lent health problems associated with drug addic- tion (16). Drug abuse has both direct and indirect consequences for oral health and can exacerbate oral problems indirectly through its adverse ef- fects on the users’ behavior and life style (8, 17). The importance and seriousness of oral health problems among drug abusers necessitates making comprehensive dental care programs available to them. These programs should be integrated into general health care services (8, 11, 16, 18). Moreo- ver, the programs should take advantage of multi- ple approaches involving education, prevention, and treatment. However, considering the illegal nature of drug abuse, either receiving services or providing them, presents several challenges. Published data about epidemiology, pathological time course, clinical presentation, and effective treatment and preventive strategies regarding oral health among drug addicts worldwide are lacking (8, 17, 19,20). This paper briefly reviews oral health consequences of illicit drug abuse, the role of dental care in addiction rehabilitation, health services available for addicts, and barriers against oral health promotion among these patients. Fi- nally, we offer possible strategies at various levels for oral health promotion among addicts which can serve as a framework for future research and interventions. Oral health consequences of illicit drug abuse Excluding smoking and tobacco use as well as al- cohol drinking, published evidence on effects of main categories of illegal drugs on oral health is growing. These drug categories include opiates, cannabis, hallucinogens, cocaine- and ampheta- mine-type stimulants, and various club drugs. Oral health complications associated with drug abuse may result from direct exposure of oral tissues to drugs during smoking or ingestion, biologic inter- action of drugs with normal physiology of oral cavity, and effects of drugs on brain function which result in a spectrum of addictive behaviors such as risk-taking behavior, poor hygiene, aggres- sion, and carelessness. Iranian J Publ Health, Vol. 42, No.9, Sep 2013, pp. 929-940 931 Available at: http://ijph.tums.ac.ir Oral health problems associated with opiates Opiate drugs include opium, its psychoactive con- stituents such as morphine, and its semi-synthetic derivatives such as heroin (2). Opioid, as a broad- er term, also includes the synthetic derivatives of this family such as methadone. In opiate drug us- ers, tooth loss, tooth extractions (17), and general- ized tooth decay especially on smooth and cervical surfaces are common (21). Moreover, salivary hypofunction among these patients leads to xero- stomia, burning mouth, taste impairment, eating difficulties, mucosal infections, and periodontal diseases (22). Periodontal diseases appear usually in the form of adult periodontitis, although re- ports also exist of necrotizing gingivitis (23,24). Heroin users show poor oral health in terms of caries and periodontal diseases (25-26). A study on heroin injectors reported that regardless of their oral hygiene, these patients suffer from progres- sive dental caries (27). Covering a wider area than typical cervical lesions, caries in these patients is darker and usually limited to buccal and labial sur- faces. This pattern may be pathognomonic for heroin abuse (28). Other oral conditions related to opioid addiction include bruxism, candidosis, and mucosal dyspla- sia (22). However, insufficient evidence exists to support a theory of a higher prevalence of oral cancer specifically in opioid abusers (29). Oral health problems associated with cannabis Cannabis abuse, mainly hashish and marijuana, leads to increased risk of oral cancer, dry mouth, and periodontitis (30-32). Onset of periodontitis among young adults has a dose-response associa- tion with cannabis abuse regardless of concurrent tobacco smoking (30). A systematic review by Versteeg et al. (33) showed oral side-effects of cannabis to include xerostomia, leukoedema, high prevalence of Candida albicans but not candidiasis, and higher DMF scores, and especially their D component (34). Based on one study, cannabis does not elevate the risk of caries by itself. The life-style of cannabis users combined with short- term decrease in saliva makes them highly suscep- tible to smooth-surface caries (35). Moreover, in another study, about half the cannabis users re- ported pulpitis during the period of cannabis smoking, a condition that may be attributed to cannabis as having adverse effects on their vascu- lature (36). Oral health problems associated with stimu- lants Stimulants including amphetamine, methampheta- mine, cocaine, and crack-cocaine (2) have signifi- cant adverse effects on oral and dental health. De- pending on the main method of drug administra- tion, cocaine abusers show several oral and facial manifestations. Cocaine snorting is associated with nasal septum perforation, changes in sense of smell, chronic sinusitis, and perforation of the pal- ate. Oral administration of cocaine may result in gingival lesions (37). Local application of cocaine onto the gingiva by addicts to test its quality may lead to gingival recession (38). Bruxism is a com- mon complication in cocaine users leading to den- tal attrition (37). Following its oral or nasal appli- cation, cocaine powder reduces saliva pH, making the dentition susceptible to dental erosion (39). Crack-cocaine smoking produces burns and sores on the lips, face, and inside of the mouth which may increase the risk of oral transmission of HIV (40). Methamphetamine abusers show bruxism, exces- sive tooth wear, xerostomia, and rampant caries (so-called meth mouth) (20, 41-43): a condition described by patients as "blackened, stained, rot- ting, crumbling or falling apart" (44). This is a dis- tinct pattern of caries on buccal and cervical smooth tooth surfaces and proximal surfaces of the anterior teeth (41, 45). A direct relationship between rampant caries and methamphetamine abuse has, however, not yet been established. A wide range of behavioral factors in addition to drugs can contribute to dental caries in these pa- tients: methamphetamine users face an increased risk of caries, related to lack of oral hygiene, high sugar intake, and decreased salivary secretion (20, 42, 46). Following the use of stimulants, patients report tooth grinding and clenching, both of which result in tooth wear, tooth sensitivity, and difficulty in chewing and in jaw opening (8). Shekarchizadeh et al.: Oral Health of Drug Abusers… Available at: http://ijph.tums.ac.ir 932 Oral health problems associated with hallucino- gens Hallucinogens such as ecstasy and LSD (Lysergic acid diethylamide) result in several oral oral com- plications including dry mouth, bruxism, and problems associated with malnutrition caused by drug-induced anorexia (32, 47). Chewing, grinding, and temporomandibular joint (TMJ) tenderness are frequently reported by ecstasy users (48). Ec- stasy-induced tooth wear attributed to grinding and clenching is more common on occlusal sur- faces of back teeth than on incisal edges. This problem may be more the result of jaw clenching than of tooth grinding (49,50). High intake of car- bonated drinks to overcome the sensation of dry mouth after drug-taking may lead to dental caries and erosion (47). Topical use of ecstasy may result in oral-tissue necrosis and mucosal fenestration (51). Oral health problems associated with club drugs Club drugs including methylenedioxymethamphe- tamine (MDMA), ketamine, gamma-hydroxy- butyrate (GHB), and flunitrazepam are chemical substances used mainly by young people in recrea- tional settings such as dance clubs and rave parties (52). These drugs are associated with several side- effects, among which oral complications have been frequently reported. For example, dry mouth and bruxism following the use of MDMA (ec- stasy) may aggravate oral conditions and result in dental caries and tooth wear. Increased risk of dental erosion among these patients is associated with consumption of high amounts of acidic sug- ary drinks in order to relieve xerostomia and de- hydration following use of this drug at dance par- ties. Furthermore, mucosal involvements such as ulcers, vestibular swelling, edema, and necrosis have been case-reported in ecstasy users (47). Co- caine, another drug used regularly by young peo- ple engaged in nightlife, has several orofacial side- effects such as nasal septum perforation, perfo- ration of the palate, gingival involvement, erosion, and excessive tooth wear. These side-effects have been reported especially with concomitant use of ecstasy (37). Indirect effects of drugs on oral health It is difficult to identify and isolate the root causes of oral diseases among addicts, since they show a variety of unhealthy behaviors (17, 46). Poor oral hygiene, increased sugar intake, and inappropriate nutrition are examples (17,26,53,54). Furthermore, a low priority set on oral health associated with a need to obtain drugs, fear of dentists, dental service acceptability, needle-phobia, self-medication, and structural factors in their life style lead to low use of dental services (8). This multifactorial association between drug abuse and insufficient oral health is also complicated by factors such as low socioeconomic status, limited education, and poor access to dental services (55). The difficulty of accessing dental services among drug abusers has been pointed out by several studies (11, 16, 19, 56). The cause may be the illegal nature of drug abuse which results in problems with either delivery of services or receipt of them. According to various studies, a high rate of trau- matic orofacial injuries occurs among drug abus- ers, ones such as fractured teeth or tooth loss fol- lowing accidents or fights (8, 17, 57). What has therefore been suggested is that in all patients with dental trauma, the possibility of drug abuse should be considered (58). One study in Iran emphasized drug abuse as a contributing factor in almost all kinds of trauma, especially in violent injuries among young adults: around 27% of trauma pa- tients in this study showed evidence of drug abuse (59). Negative effects of drug addiction treatment on oral health Methadone—a synthetic opioid widely used in management of opiate addiction—has several possible side-effects on oral health. High sugar content of an acidic nature, along with suppression of salivary secretion results in dental caries, erosion, and xerostomia (60). The status turns even more severe when patients hold this sugary syrup in their mouth to increase absorption time or to regurgitate it for later injection or sale (11). Sugar-free solutions, however, may reduce the risk of dental caries (60). Iranian J Publ Health, Vol. 42, No.9, Sep 2013, pp. 929-940 933 Available at: http://ijph.tums.ac.ir Some other medications used during drug addic- tion treatment include antidepressants (tricyclic, selective serotonin reuptake inhibitors), anti- psychotics such as phenothiazines for treatment of schizophrenia, and anti-anxiety drugs such as diazepam. They have a side-effect of salivary gland hypofunction and subsequent dry mouth leading to negative effects on oral health (61-63). In addi- tion, with regard to the higher prevalence of HIV among injecting drug users (64), anti-HIV drugs such as dideoxyinosine and protease inhibitors may also have the side-effect of dry mouth (63). Xerogenic patients usually have problems with chewing, swallowing, tasting, or speaking. They may develop cracked lips, erythematic mucosa and sores, tooth decay, and periodontitis. Halitosis is also a common finding among these patients (62). The role of oral health care (OHC) in addic- tion rehabilitation/ Oral health and relapse During treatment, drug withdrawal may result in dental pain which interferes with treatment proce- dure and abstinence, and may lead to relapse (18, 27, 58). In a French case-control study of the im- pact of illicit drugs on oral health and the use of drugs for toothache, 52% of intravenous heroin users and 21% of other illicit drug abusers admit- ted using drugs as pain-killers (27). A similar find- ing on use of illicit drugs for toothache emerged from another study (36). Those quitting opiate use therefore require special care for pain control, and this should be integrated into their rehabilitation program (18, 27, 58). Those addiction treatment centers which provide OHC seem to be more successful in promoting both the oral and general health of their patients (65). Dental pain relief provided by illegal drugs such as heroin, cocaine, and methadone may also be one cause of low dental attendance: many of the pa- tients self-medicate for toothache even by inject- ing drugs directly into gingiva or teeth, masking pain and delaying appropriate treatment (8, 36). Oral health, destigmatization, and resocialization Dental care for patients receiving drug rehabilita- tion treatment can improve their oral health, help them to recover from drug abuse and to recon- struct a “non-addict” identity (8). Based on one study, former drug users were embarrassed about how their mouths looked, but this did not inter- fere with their resocialization (66). In another study of intravenous heroin users, the appearance of their smile had negative effect on their social life (27). Oral health and HIV transmission Illicit drugs such as methamphetamines may lead to an increase in risky sexual behaviors resulting in the spread of infectious diseases such as HIV and AIDS (67). Transmission of HIV via oral sex; however, seems to be less frequent, with the oral cavity being an unusual route of HIV transmission (68-70). Nonetheless, oral trauma and ulcers may enhance the risk of HIV transmission (70). For example, the possibility of oral HIV transmission may increase via burns and sores on lips, face, and in the mouth following the smoking of crack-co- caine (40). Health services for drug addicts Various health care systems around the world de- liver diverse services for addicts in terms of treat- ment services provided, pharmacotherapy, human resources, financing methods, and prevention- and harm-reduction facilities. Treatment services may also be available in the forms of inpatient or outpatient medical detoxification, outpatient absti- nence-oriented treatment, and substitution maintenance therapy for opioid dependence (71). Opioid agonist treatment with either methadone or buprenorphine may be implemented in a vari- ety of settings such as public general hospitals, public mental health hospitals, and public treat- ment centers, plus private treatment centers, pri- vate practice (psychiatrists), primary health care, community pharmacies, and prisons. In addition, the proportion of patients treated in the public sector, private sector, joint public-private sector ventures, and NGOs varies substantially among countries. Policies on prevention methods and harm-reduction facilities may also vary depending on the country. These facilities include commu- nity-based needle-exchange programs, needle-ex- change programs in prisons, supervised injection Shekarchizadeh et al.: Oral Health of Drug Abusers… Available at: http://ijph.tums.ac.ir 934 facilities, outreach services for injecting drug users, naloxone distribution, community-based bleach distribution, and in prisons bleach distribution (71-73). With 1.2 million problematic drug users living in the country (74), Iran has confronted a huge drug abuse problem. Nonetheless, the nation’s treat- ment procedures are new (75). Treatment for sub- stance abuse includes inpatient care and intensive outpatient programs. In spite of the criminal na- ture of drug abuse, as a psychiatric disorder, in- treatment drug users in Iran are no longer prose- cuted. From 1994, the Prevention Deputy of the Iranian Welfare Organization set up outpatient centers for treatment of drug users (76). These centers offer the following services: detoxification, agonist-maintenance therapy, and individual, group, and family counseling, as well as relapse prevention, self-help groups, and psychotherapy (75). Approximately 1,438 centers across the country serve 642,516 patients. Among the cen- ters, 85% belong to the private sector. In Tehran province are located 262 treatment centers includ- ing 250 nongovernmental and only 12 govern- mental centers working with 746 professionals, including 239 medical doctors, 61 psychiatrists, 138 nurses, 79 social workers, and 229 psycholo- gists (77). A treatment center serving female drug users only was established in 2007 in Tehran to reduce drug-related harm among women (78). Based on a Rapid Situation Assessment (RSA) 2007 report, most of the drug users had received outpatient treatment in private centers (74). In addition to treatment centers, Narcotic Anony- mous groups and Therapeutic Communities were established in the country in 1994 and in 2001, respectively. Furthermore, a number of NGOs also exist, offering consultation and group therapy by former drug users (76). In contrast to many countries in the Middle East and North Africa, Iran has established maintenance treatment with methadone for those opioid-dependents who are in prison as an HIV-prevention package. At pre- sent, 142 prisons in all 30 provinces of Iran pro- vide MMT programs for injecting and non-inject- ing opioid drug users (79). Despite the seriousness of oral health problems among addicts and positive effects of dental care in addiction rehabilitation, these patients’ use of dental services at a low rate (18, 56). Addiction literature is also scarce regarding the topic of den- tal and oral health care (80). A few programs have been implemented to improve access to dental care among drug users (11, 18, 56,57), but a dis- tinct lack of published data explain access to care (11). In Iran, as in most countries worldwide, cur- rent health care services for addicts lack OHC programs. Barriers against oral health promotion among drug addicts Challenges to provision of an evidence-based picture of the oral health situation There appear to be some challenges and barriers to research studies in this field, ones that are vital in order to provide reliable evidence for further interventions. It is difficult to access drug addicts as a target population. In addition to problems with drug abusers’ cooperation with and compli- ance in oral health studies, problems with their long-term follow-up are common (8, 81). The multifactorial and complex nature of drug abuse and addictive behaviors and a tendency to- ward poly-drug abuse among addicts cause diffi- culties in determining the independent effects of each group of drugs or each aspect of addictive behavior on various oral health aspects (17). This may interfere with acquiring a reliable picture of oral health situation. Challenges in providing and implementing effective treatments/interventions Despite evidence as to addicts’ oral health prob- lems, several barriers exist against provision of preventive and curative interventions. Dental pro- fessionals usually have negative attitudes toward and unwillingness to treat addicted dental patients (82). On the other hand, addicts generally show a low demand for non-emergency dental care and put a low priority on their oral health (8, 10-11, 66) In addition to the problems with utilization of dental services (56, 83), they may have problems with compliance with treatment procedures and Iranian J Publ Health, Vol. 42, No.9, Sep 2013, pp. 929-940 935 Available at: http://ijph.tums.ac.ir fail to accept the suggested treatment plan (8, 45, 56). Finally, lack of appropriate policies to improve access to oral health services (16) and poor col- laboration between dental and general health care sectors serving drug addicts (23, 56) are other ob- stacles to effective interventions. Strategies for oral health promotion among drug addicts The following strategies serve as a framework for future research and interventions (Figure 1). Investigating oral health conditions in drug addicts Evaluating the status of oral health among drug addicts would be possible by either objective or subjective methods. Objective evaluation via clini- cal examination may serve to identify specific pat- terns of oral conditions related to drugs, to deter- mine appropriate dental indices in order to inves- tigate addicts’ oral health, and to identify effects of addiction treatment protocols on their oral condi- tion. Subjective evaluation via questionnaire or in- terview provides information on the self- perception of participants, including self-perceived oral health and its association with occurrence and relapse of addiction, self-perceived barriers against dentalservice utilization, oral health behavior, and oral health-related quality of life. Oral health care interventions for drug addicts Interventions available to drug addicts mainly in- clude oral health education and prevention as first-level care, and delivery of dental services as second-level care. Examples of the former include empowering dentists on the one hand, and health care personnel in drug rehabilitation settings on the other to provide oral health education and prevention for addicts and their families, and to provide educational materials (booklets, posters, brochures, etc.) regarding prevention of oral prob- lems. As second-level care: 1) Dental services should be established in addiction rehabilitation centers to improve access to dental treatment. 2) Dentists should be empowered in the following domains to provide treatment services for addicts: a. Diagnosis and management of oral prob- lems in addicts b. Management of systemic disorders related to addiction during dental treatments c. Behavioral and psychological management of addicts during dental treatments d. Encouraging dentists’ positive attitude to- ward addicts e. Cross-infection control of blood-borne diseases Discussion Generally, OHC for drug abusers causes a huge challenge for society. Because of the aforemen- tioned reasons, drug abusers have frequent and special dental needs and compared to their normal population counterparts are in greater need of ac- cess to dental treatments (8, 11, 16, 19, 56, 83). Thus, it seems necessary to integrate OHC pro- grams into general health services provided for drug addicts. Prevention and treatment of oral diseases among drug addicts may facilitate their rehabilitation treat- ment and recovery from drug dependence (8). Most health care-delivery systems around the world, however, lack OHC programs for addicts. Several barriers seem to exist against oral health promotion among drug addicts at both research and interven- tion levels. Because of the complexities of such an extensive team work, a multidisciplinary collabora- tion is necessary to conduct comprehensive re- search. Lack of appropriate settings such as specific dental clinics, and equipment inside drug rehabilita- tion centers, and lack of valid inventories and as- sessment protocols to detect common oral compli- cations among drug users are problems. Addition- ally, lack of comprehensive knowledge of and in- terest among dental professionals in the im- portance and necessity of relevant studies, and a common worry over possible threats of transmis- sion of HIV and hepatitis viruses during oral as- sessment of drug dependents interfere with appro- priate need assessment. Shekarchizadeh et al.: Oral Health of Drug Abusers… Available at: http://ijph.tums.ac.ir 936 Fig. 1: Oral health care strategies for drug addicts Iranian J Publ Health, Vol. 42, No.9, Sep 2013, pp. 929-940 937 Available at: http://ijph.tums.ac.ir In addition to the high cost of dental services and low coverage of dental insurance, concerns among policy-makers as to the cost-effectiveness of such interventions, especially in countries with develop- ping health care systems, may obstruct useful oral health interventions for addicts. The relationship between drug abuse and oral complications provides an opportunity for dental professionals to detect drug abusers at early stages and refer them for rehabilitation. This approach can increase cost-effectiveness of interventions for drug control (46). Conclusion Despite the seriousness of oral health problems among drug addicts and positive effects of dental care in addiction rehabilitation, provision of effec- tive OHC for these patients seems to face chal- lenges including difficulty to access addicts as a target population, lack of appropriate settings to conduct oral health studies, lack of valid invento- ries and assessment protocols to detect common orodental pathologies among drug users, poor col- laboration between dental and general health care sectors serving drug addicts, lack of appropriate policies to improve access to dental services by these patients, lack of comprehensive knowledge of and interest among dental professionals in treating addicts, and low demand for non-emer- gency dental care among these patients. Regardless of all these barriers, OHC for drug ad- dicts merits more emphasis in the future and should be implemented at various levels including education, preventive interventions, and therapeu- tic procedures. Moreover, because of the com- plexities of medical, social, psychological, and be- havioral conditions of drug abusers, management of drug addiction as a multi-organ disease needs a multidisciplinary approach. Current health care programs for drug addicts usually lack OHC ele- ments. Published evidence on oral complications related to drug addiction emphasizes that OHC programs should be integrated into general care services already available for drug abusers. Ethical considerations Ethical issues (Including plagiarism, Informed Consent, misconduct, data fabrication and/or fal- sification, double publication and/or submission, redundancy, etc.) have been completely observed by the authors. Acknowledgement This study has been supported by Tehran Univer- sity of Medical Sciences and Health Services Grant number 12900. The authors declare that there is no conflict of interest. References 1. Nessa A, Latif SA, Siddiqui NI, Hussain MA, Hossain MA (2008). Drug abuse and addic- tion. Mymensingh Med J, 17 (2): 227-35. 2. United Nations Office on Drug and Crime (2011). World Drug Report 2011. Vienna: United Nations Publication, Sales No. E.11.XI.10. 3. Mathers BM, Degenhardt L, Phillips B, Wiessing L, Hickman M, Strathdee SA, Wodak A, Pan- da S, Tyndall M, Toufik A, Mattick RP (2008). Global epidemiology of injecting drug use and HIV among people who inject drugs: a sys- tematic review. Lancet, 372 (9651): 1733. 4. Rahimi Movaghar A, Mohammad K, Razzaghi EM (2002). Trend of drug abuse situation in Iran: a three-decade survey. Hakim Research Journal, 5 (3): 171-81. [Abstract in English] 5. Chen CY, Lin KM (2009). Health consequences of illegal drug use. Curr Opin Psychiatry, 22 (3): 287-92. 6. Brienza RS, Stein MD, Chen M, Gogineni A, Sobota M, Maksad J, Hu P, Clarke J (2000). Depression among needle exchange program and methadone maintenance clients. J Subst Abuse Treat, 18 (4): 331-7. 7. Affinnih YH (1999). A preliminary study of drug abuse and its mental health and health conse- quences among addicts in Greater Accra, Ghana. J Psychoactive Drugs, 31 (4): 395-403. 8. Robinson PG, Acquah S, Gibson B (2005). Drug users: oral health-related attitudes and behav- iours. Br Dent J, 198 (4): 219-24. Shekarchizadeh et al.: Oral Health of Drug Abusers… Available at: http://ijph.tums.ac.ir 938 9. Santolaria-Fernández FJ, Gómez-Sirvent JL, González-Reimers CE, Batista-López JN, Jorge-Hernández JA, Rodríguez-Moreno F, Martínez-Riera A, Hernández-García MT (1995). Nutritional assessment of drug addicts. Drug Alcohol Depend, 38 (1): 11-8. 10. De Palma P, Nordenram G (2005). The percep- tions of homeless people in Stockholm con- cerning oral health and consequences of dental treatment: a qualitative study. Spec Care Dentist, 25 (6): 289-95. 11. Charnock S, Owen S, Brookes V, Williams M (2004). A community based programme to im- prove access to dental services for drug users. Br Dent J, 196 (7): 385-8. 12. Rehm J, Taylor B, Room R (2006). Global burden of disease from alcohol, illicit drugs and to- bacco. Drug Alcohol Rev, 25 (6): 503-13. 13. Eaton WW, Martins SS, Nestadt G, Bienvenu OJ, Clarke D, Alexandre P (2008). The burden of mental disorders. Epidemiol Rev, 30: 1-14. 14. Ministry of Health and Medical Education (2007). Study of the burden of oral disease and injuries in Iran. MOHME. [Summary in English] 15. United Nations Office on Drug and Crime (1998). Economic and social consequences of drug abuse and illicit trafficking. (Available at: http://www.unodc.org/pdf/technical_series_ 1998-01-01_1.pdf) [Last access on May 2013] 16. Metsch LR, Crandall L, Wohler-Torres B, Miles CC, Chitwood DD, McCoy CB (2002). Met and unmet need for dental services among ac- tive drug users in Miami, Florida. J Behav Health Serv Res, 29 (2): 176-88. 17. Reece AS (2007). Dentition of addiction in Queensland: poor dental status and major con- tributing drugs. Aust Dent J, 52 (2): 144-9. 18. Molendijk B, Ter Horst G, Kasbergen M, Truin GJ, Mulder J (1996). Dental health in Dutch drug addicts. Community Dent Oral Epidemiol, 24 (2): 117-9. 19. Laslett AM, Dietze P, Dwyer R (2008). The oral health of street-recruited injecting drug users: prevalence and correlates of problems. Addic- tion, 103 (11): 1821-5. 20. Morio KA, Marshall TA, Qian F, Morgan TA (2008). Comparing diet, oral hygiene and caries status of adult methamphetamine users and nonusers: a pilot study. J Am Dent Assoc, 139 (2): 171-6. 21. Rees TD (1992). Oral effects of drug abuse. Crit Rev Oral Biol Med, 3(3):163-84. 22. Titsas A, Ferguson MM (2002). Impact of opioid use on dentistry. Aust Dent J, 47 (2): 94-8. 23. Angelillo IF, Grasso GM, Sagliocco G, Villari P, D'Errico MM (1991). Dental health in a group of drug addicts in Italy. Community Dent Oral Epidemiol, 19 (1): 36-7. 24. Davis RK, Baer PN (1971). Necrotizing ulcerative gingivitis in drug addict patients being with- drawn from drugs. Report of two cases. Oral Surg Oral Med Oral Pathol, 31 (2): 200-4. 25. Ma H, Shi XC, Hu DY, Li X (2012). The poor oral health status of former heroin users treat- ed with methadone in a Chinese city. Med Sci Monit, 18 (4): PH51-5. 26. Picozzi A, Dworkin SF, Leeds JG, Nash J (1972). Dental and associated attitudinal aspects of heroin addiction: a pilot study. J Dent Res, 51 (3): 869. 27. Madinier I, Harrosch J, Dugourd M, Giraud- Morin C, Fosse T (2003). The buccal-dental health of drug addicts treated in the University hospital centre in Nice. Presse Med, 32 (20): 919-23. 28. Lowenthal AH (1967). Atypical caries of the nar- cotics addict. Dent Surv, 43 (12): 44-7. 29. Llewelyn J, Mitchell R (1994). Smoking, alcohol and oral cancer in south east Scotland: a 10- year experience. Br J Oral Maxillofac Surg, 32 (3): 146-52. 30. Thomson WM, Poulton R, Broadbent JM, Mof- fitt TE, Caspi A, Beck JD, Welch D, Hancox RJ (2008). Cannabis smoking and periodontal disease among young adults. JAMA, 299 (5): 525-31. 31. Ahrens AGMS, Bressi T (2007). Marijuana as promoter for oral cancer? More than a suspect. Addictive Disorders & Their Treatment, 6 (3): 117. 32. Fazzi M, Vescovi P, Savi A, Manfredi M, Perac- chia M (1999). The effects of drugs on the oral cavity. Minerva Stomatol, 48 (10): 485. 33. Versteeg PA, Slot DE, van der Velden U, van der Weijden GA (2008). Effect of cannabis usage on the oral environment: a review. Int J Dent Hyg, 6 (4): 315-20. 34. Di Cugno F, Perec CJ, Tocci AA (1981). Salivary secretion and dental caries experience in drug addicts. Arch Oral Biol, 26 (5): 363-7. 35. Schulz-Katterbach M, Imfeld T, Imfeld C (2009). Cannabis and caries--does regular cannabis use Iranian J Publ Health, Vol. 42, No.9, Sep 2013, pp. 929-940 939 Available at: http://ijph.tums.ac.ir increase the risk of caries in cigarette smokers? Schweiz Monatsschr Zahnmed, 119 (6): 576-83. 36. Madinier I (2002). Illicit drugs for toothache. Br Dent J, 192 (3): 120. 37. Blanksma CJ, Brand HS (2005). Cocaine abuse: orofacial manifestations and implications for dental treatment. Int Dent J, 55 (6): 365-9. 38. Kapila YL, Kashani H (1997). Cocaine-associated rapid gingival recession and dental erosion. A case report. J Periodontol, 68 (5): 485-8. 39. Krutchkoff DJ, Eisenberg E, O'Brien JE, Ponzil- lo JJ (1990). Cocaine-induced dental erosions. N Engl J Med, 322 (6): 408. 40. Faruque S, Edlin BR, McCoy CB, Word CO, Larsen SA, Schmid DS, Von Bargen JC, Ser- rano Y (1996). Crack cocaine smoking and oral sores in three inner-city neighborhoods. J Ac- quir Immune Defic Syndr Hum Retrovirol, 13 (1): 87-92. 41. Hamamoto DT, Rhodus NL (2009). Metham- phetamine abuse and dentistry. Oral Dis, 15 (1): 27-37. 42. Saini T, Edwards PC, Kimmes NS, Carroll LR, Shaner JW, Dowd FJ (2005). Etiology of xero- stomia and dental caries among methampheta- mine abusers. Oral Health Prev Dent, 3 (3): 189- 95. 43. Richards JR, Brofeldt BT (2000). Patterns of tooth wear associated with methamphetamine use. J Periodonto, 71 (8): 1371-4. 44. ADA Division of Communications; Journal of the American Dental Association; ADA Divi- sion of Scientific Affairs (2005). For the dental patient ... methamphetamine use and oral health. J Am Dent Assoc, 136 (10): 1491. 45. Shaner JW (2002). Caries associated with meth- amphetamine abuse. J Mich Dent Assoc, 84 (9): 42-7. 46. Cretzmeyer M, Walker J, Hall JA, Arndt S (2007). Methamphetamine use and dental disease: re- sults of a pilot study. J Dent Child (Chic), 74 (2): 85-92. 47. Brand HS, Dun SN, Nieuw Amerongen AV (2008). Ecstasy (MDMA) and oral health. Br Dent J, 204 (2): 77-81. 48. McGrath C, Chan B (2005). Oral health sensa- tions associated with illicit drug abuse. Br Dent J, 198 (3): 159-62. 49. Milosevic A, Agrawal N, Redfearn P, Mair L (1999). The occurrence of toothwear in users of Ecstasy (3,4-methylenedioxymethampheta- mine). Community Dent Oral Epidemiol, 27 (4): 283-7. 50. Redfearn PJ, Agrawal N, Mair LH (1998). An as- sociation between the regular use of 3,4 meth- ylenedioxy-methamphetamine (ecstasy) and excessive wear of the teeth. Addiction, 93 (5): 745-8. 51. Brazier WJ, Dhariwal DK, Patton DW, Bishop K (2003). Ecstasy related periodontitis and mu- cosal ulceration -- a case report. Br Dent J, 194 (4): 197-9. 52. Gahlinger PM (2004). Club drugs: MDMA, gamma-hydroxybutyrate (GHB), Rohypnol, and ketamine. Am Fam Physician, 69: 2619-26. 53. Shekarchizadeh H, Khami MR, Mohebbi SZ, Vir- tanen JI (2013). Oral health behavior of drug addicts in withdrawal treatment. BMC Oral Health,13:11. 54. Zador D, Lyons Wall PM, Webster I (1996). High sugar intake in a group of women on metha- done maintenance in south western Sydney, Australia. Addiction, 91 (7): 1053-61. 55. Scheutz F (1984). Dental health in a group of drug addicts attending an addiction-clinic. Community Dent Oral Epidemiol, 12 (1): 23-8. 56. Sheridan J, Aggleton M, Carson T (2001). Dental health and access to dental treatment: a com- parison of drug users and non-drug users at- tending community pharmacies. Br Dent J, 191 (8): 453-7. 57. Scheutz F (1985). Five year evaluation of a dental care delivery system for drug addicts in Den- mark. Community Dent Oral Epidemiol, 12: 29-34. 58. Bullock K (1999). Dental care of patients with substance abuse. Dent Clin North Am, 43 (3): 513-26. 59. Soroush A R, Modaghegh M H S, Karbakhsh M, Zarei M R (2006). Drug abuse in hospitalized trauma patients in a university trauma care cen- ter: an explorative study. Tehran University Medi- cal Journal, 64 (8): 43-8. [Abstract in English] 60. Nathwani NS, Gallagher JE (2008). Methadone: dental risks and preventive action. Dent Update, 35 (8): 542-4, 547-8. 61. Ship JA (2004). Xerostomia: aetiology, diagnosis, management and clinical implications. In: Sa- liva and Oral Health. Eds, M Edgar, C Davies, D O’ Mullane. BDJ Books, London, pp. 50. 62. Cassolato SF, Turnbull RS (2003). Xerostomia: clinical aspects and treatment. Gerodontolog, 20 (2): 64-77. Shekarchizadeh et al.: Oral Health of Drug Abusers… Available at: http://ijph.tums.ac.ir 940 63. Scully C (2003). Drug effects on salivary glands: dry mouth. Oral Dis, 9 (4): 165-76. 64. Arasteh K, Des Jarlais DC, Perlis TE (2008). Al- cohol and HIV sexual risk behaviors among injection drug users. Drug Alcohol Depend, 95 (1- 2): 54-61. 65. Fan J, Hser YI, Herbeck D (2006).Tooth reten- tion, tooth loss and use of dental care among long-term narcotics abusers. Subst Abus, 27 (1- 2): 25-32. 66. Scheutz F (1985). Dental habits, knowledge, and attitudes of young drug addicts. Scand J Soc Med, 13 (1): 35-40. 67. Shariatirad S, Maarefvand M, Ekhtiari H (2013). Emergence of a methamphetamine crisis in Iran. Drug Alcohol Rev, 32 (2): 223-4. 68. Campo J, Perea MA, del Romero J, Cano J, Her- nando V, Bascones A (2006). Oral transmis- sion of HIV, reality or fiction? An update. Oral Dis, 12 (3): 219-28. 69. Page-Shafer K, Shiboski CH, Osmond DH, Dil- ley J, McFarland W, Shiboski SC, Klausner JD, Balls J, Greenspan D, Greenspan JS (2002). Risk of HIV infection attributable to oral sex among men who have sex with men and in the population of men who have sex with men. AIDS, 16 (17): 2350-2. 70. Scully C, Porter S (2000). HIV topic update: oro- genital transmission of HIV. Oral Dis, 6 (2): 92. 71. World Health Organization. Management of sub- stance abuse. Country profiles: Resources for the Prevention and Treatment of Substance Use Disorders. (Available at: http://www.- who.int/substance_abuse/publictions/atlas_re port/profiles/en/index.html#U) [Last access on May 2013] 72. World Health Organization (2009). Assessment of Compulsory Treatment of People Who Use Drugs in Cambodia, China, Malaysia and Viet Nam: an ap- plication of Selected Human Rights Principles. (Avail- able at: http://www.wpro.who.int/publications/docs /FINALforWeb_Mar17_Compulsory_Treat- ment.pdf) [Last access on May 2013] 73. Department of Health (England) and the de- volved administrations (2007). Drug Misuse and Dependence: UK Guidelines on Clinical Management. London: Department of Health (England), the Scottish Government, Welsh Assembly Gov- ernment and Northern Ireland Executive. 74. Iranian Drug Control Headquarter (2007). Na- tional Rapid Situation Analysis of Drug Abuse Status in Iran. Iran: Presidency. 75. United Nations Office on Drug and Crime. Triangular Clinic & Rehabilitation Centre, Iran. (Available at: http://www.unodc.org/treatment/en/Iran_re source_centre_11.html) [Last access on May 2013] 76. Mokri A (2002). Brief overview of the status of drug abuse in Iran. Arch Iranian Med, 5 (3): 184. 77. Ministry of Health and Medical Education (2008). Data Registration of Substance Abuse Treat- ment Centers (Social Welfare Organization, Universities of Medical Sciences, State Pris- ons). Drug Addiction Office. [Unpublished re- port] 78. Dolan K, Salimi S, Nassirimanesh B, Mohsenifar S, Mokri A (2011). The establishment of a methadone treatment clinic for women in Tehran, Iran. J Public Health Policy, 32 (2): 219. 79. Farnia M, Ebrahimi B, Shams A, Zamani S (2010). Scaling up methadone maintenance treatment for opioid-dependent prisoners in Iran. Int J Drug Policy, 21 (5): 422-4. 80. Turner BJ, Laine C, Cohen A, Hauck WW (2002). Effect of medical, drug abuse, and mental health care on receipt of dental care by drug users. J Subst Abuse Treat, 23 (3): 239-46. 81. Ribeiro Edel P, Oliveira JA, Zambolin AP, Lauris JR, Tomita NE (2002). Integrated approach to the oral health of drug-addicted undergoing rehabilitation. Pesqui Odontol Bras, 16 (3): 239. 82. Dawkes M, Sparkes S, Smith M (1995). Dentists' responses to drug misusers. Health Trends, 27 (1): 12-4. 83. Robbins JL, Wenger L, Lorvick J, Shiboski C, Kral AH (2010). Health and oral health care needs and health care-seeking behavior among homeless injection drug users in San Francisco. J Urban Health, 87 (6): 920-30.