Seppälä, Toni T.Burkhart, Richard A.Katona, Bryson W.2023-06-082023-06-082023-05-05Seppälä, T T, Burkhart, R A & Katona, B W 2023, 'Hereditary colorectal, gastric, and pancreatic cancer : comprehensive review', BJS open, vol. 7, no. 3, zrad023. https://doi.org/10.1093/bjsopen/zrad023ORCID: /0000-0002-4940-3498/work/136648626http://hdl.handle.net/10138/358494Hereditary gastrointestinal cancers are under-diagnosed and require attention for identification and differential diagnostics with easy access to germline genetic evaluation to confirm the diagnosis. Awareness of multiple predisposing conditions to cancers in various organs, also outside the gastrointestinal tract, is imperative in identification and prompting surveillance and management according to condition-specific clinical guidelines available.Background Inheritance patterns show familial clustering of gastrointestinal cancers, and multiple germline conditions have now been identified that predispose to colorectal, gastric, and pancreatic cancers. Methods A narrative review based on recent relevant literature was conducted. Results Lynch syndrome, formerly known as hereditary non-polyposis colorectal cancer, increases the risk of several abdominal cancers, with the highest population prevalence. Familial adenomatous polyposis and some of the more infrequent polyposis syndromes have distinct characteristics affecting various organ-specific cancer risks. Hereditary gastric and pancreatic cancer syndromes include those also causing colorectal cancer, while additional genetic disorders predisposing only to upper gastrointestinal malignancies have been recognized more recently. Diagnosing and managing hereditary cancer syndromes requires multidisciplinary expertise and may be best managed in tertiary centres, with a need to consider patient preference and ensure shared decision-making. Conclusion Several germline conditions predispose to colorectal, gastric, and pancreatic cancer, which inform identification, surveillance regimens, prevention, cascade screening, counselling, and surgical management. The authors describe developments in the hereditary origin of colorectal, gastric, and pancreatic cancer with current recommendations in surveillance and surgical management.19engcc_byinfo:eu-repo/semantics/openAccessClinical-practice guidelinesHigh-risk individualsMismatch repair geneLynch-syndromeAmerican societyGermline mutationsProximal polyposisFukuoka guidelinesCost-effectivenessBreast-cancerSurgery, anesthesiology, intensive care, radiologyReview ArticleopenAccessb43b9d4b-429a-4799-afcc-0c40c95ee8e63716569785161632346000985917700001