Robinson, RachelLahti-Pulkkinen, MariusHeinonen, KatiReynolds, Rebecca M.Räikkönen, Katri2020-01-132020-01-132019-01Robinson, R, Lahti-Pulkkinen, M, Heinonen, K, Reynolds, R M & Räikkönen, K 2019, 'Fetal programming of neuropsychiatric disorders by maternal pregnancy depression: a systematic mini review', Pediatric Research, vol. 85, no. 2, pp. 134-145. https://doi.org/10.1038/s41390-018-0173-yBibtex: urn:9060998ab1246318a37cd5e7530786efORCID: /0000-0002-5244-5525/work/55613860ORCID: /0000-0003-3124-3470/work/55617109ORCID: /0000-0002-1262-5599/work/55617460ORCID: /0000-0002-6843-9103/work/55619202http://hdl.handle.net/10138/309434BACKGROUND: Maternal depression complicates a large proportion of pregnancies. Current evidence shows numerous harmful effects on the offspring. Reviews, which include depression, concluded that stress has harmful effects on the offspring's outcomes neuro-cognitive development, temperament traits, and mental disorders. OBJECTIVE: This mini review of recent studies, sought to narrow the scope of exposure and identify studies specifically assessing prenatal depression and offspring neuropsychiatric outcomes. STUDY ELIGIBILITY CRITERIA: The review included longitudinal, cohort, cross-sectional, clinical, quasi-experimental, epidemiological, or intervention study designs published in English from 2014 to 2018. PARTICIPANTS: Study populations included mother-child dyads, mother-father-child triads, mother-alternative caregiver-child triads, and family studies utilizing sibling comparisons. METHODS: We searched PubMED and Web of Science. Study inclusion and data extraction were based on standardized templates. The quality of evidence was assessed using the Newcastle-Ottawa Scale (NOS). RESULTS: Thirteen studies examining neuropsychiatric outcomes were included. We judged the evidence to be moderate to high quality. CONCLUSIONS: Our review supports that maternal prenatal depression is associated with neuropsychiatric adversities in children.12engunspecifiedinfo:eu-repo/semantics/openAccessC-REACTIVE PROTEINYOUNG-ADULTSPRENATAL EXPOSUREBEHAVIOR PROBLEMSINCREASED RISKAMYGDALA FUNCTIONAL CONNECTIVITYPOSTNATAL DEPRESSIONMENTAL-DISORDERSAUTISM SPECTRUM DISORDERSDEVELOPMENTAL ORIGINSPsychologyGynaecology and paediatricsReview ArticleopenAccess66361ad3-9ae8-4180-ba8d-0b76bf0a511885054566606000458821500006