Levanova, AlesiaPoranen, Minna M.2018-10-012018-10-012018-09-11Levanova, A & Poranen, M M 2018, 'RNA Interference as a Prospective Tool for the Control of Human Viral Infections', Frontiers in Microbiology, vol. 9, 2151. https://doi.org/10.3389/fmicb.2018.02151ORCID: /0000-0002-4775-3670/work/50290711ORCID: /0000-0002-3070-0177/work/48889062http://hdl.handle.net/10138/246111RNA interference (RNAi), which is mediated by small interfering RNAs (siRNAs) derived from viral genome or its replicative intermediates, is a natural antiviral defense in plants, fungi, and invertebrates. Whether RNAi naturally protects humans from viral invasion is still a matter of debate. Nevertheless, exogenous siRNAs are able to halt viral infection in mammals. The current review critically evaluates the production of antiviral siRNAs, delivery techniques to the infection sites, as well as provides an overview of antiviral siRNAs in clinical trials.9engcc_byinfo:eu-repo/semantics/openAccessRNA interferenceantiviral siRNAantiviral shRNAsiRNA productionsiRNA deliveryDOUBLE-STRANDED-RNARESPIRATORY SYNCYTIAL VIRUSMAMMALIAN-CELLSHEPATITIS-BSIRNA DELIVERYBACTERIOPHAGE PHI-6ANTIVIRAL IMMUNITYESCHERICHIA-COLIPOLYMERASEINHIBITIONPlant biology, microbiology, virologyReview ArticleopenAccessb5f3e4d5-c72a-4874-a967-82001712271185053139976000444297800001