López-Bueno, RubénAndersen, Lars LouisCalatayud, JoaquínCasaña, JoséGrabovac, IgorOberndorfer, MoritzDel Pozo Cruz, Borja2024-01-252024-01-252022-05-01López-Bueno, R, Andersen, L L, Calatayud, J, Casaña, J, Grabovac, I, Oberndorfer, M & Del Pozo Cruz, B 2022, 'Associations of handgrip strength with all-cause and cancer mortality in older adults : A prospective cohort study in 28 countries', Age and Ageing, vol. 51, no. 5, afac117. https://doi.org/10.1093/ageing/afac117http://hdl.handle.net/10138/570227Background: mixed evidence exists on the association between muscle strength and mortality in older adults, in particular for cancer mortality. Aim: to examine the dose-response association of objectively handgrip strength with all-cause and cancer mortality. Study Design and Setting: data from consecutive waves from the Survey of Health, Ageing and Retirement in Europe comprising 27 European countries and Israel were retrieved. Overall, 54,807 men (45.2%; 128,753 observations) and 66,576 women (54.8%; 159,591 observations) aged 64.0 (SD 9.6) and 63.9 (SD 10.2) years, respectively, were included. Cox regression and Fine-Grey sub-distribution method were conducted. Results: during the follow-up period (896,836 person-year), the fully adjusted model showed the lowest significant risk estimates for the highest third of handgrip strength when compared with the first third (reference) in men (hazard ratio [HR], 0.41; 95% confidence interval [CI], 0.34-0.50) and women (HR, 0.38; 95% CI, 0.30-0.49) for all-cause mortality. We identified a maximal threshold for reducing the risk of all-cause mortality for men (42 kg) and women (25 kg), as well as a linear dose-response association in participants aged 65 or over. No robust association for cancer mortality was observed. Conclusion: these results indicate an inverse dose-response association between incremental levels of handgrip and all-cause mortality in older adults up to 42 kg for men and 25 kg for women, and a full linear association for participants aged 65 years or over. These findings warrant preventive strategies for older adults with low levels of handgrip strength.11engcc_byinfo:eu-repo/semantics/openAccessageinglongevitylongitudinalolder peoplephysical activityphysical exercise5200 Other social sciencesArticleopenAccessc083f0d8-db1a-4261-ab8a-4fd64acbcf15000803299400004